+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prediction of body mass index in mice using dense molecular markers and a regularized neural network

, : Prediction of body mass index in mice using dense molecular markers and a regularized neural network. Genetics Research 93(3): 189-201

Bayesian regularization of artificial neural networks (BRANNs) were used to predict body mass index (BMI) in mice using single nucleotide polymorphism (SNP) markers. Data from 1896 animals with both phenotypic and genotypic (12 320 loci) information were used for the analysis. Missing genotypes were imputed based on estimated allelic frequencies, with no attempt to reconstruct haplotypes based on family information or linkage disequilibrium between markers. A feed-forward multilayer perceptron network consisting of a single output layer and one hidden layer was used. Training of the neural network was done using the Bayesian regularized backpropagation algorithm. When the number of neurons in the hidden layer was increased, the number of effective parameters, γ, increased up to a point and stabilized thereafter. A model with five neurons in the hidden layer produced a value of γ that saturated the data. In terms of predictive ability, a network with five neurons in the hidden layer attained the smallest error and highest correlation in the test data although differences among networks were negligible. Using inherent weight information of BRANN with different number of neurons in the hidden layer, it was observed that 17 SNPs had a larger impact on the network, indicating their possible relevance in prediction of BMI. It is concluded that BRANN may be at least as useful as other methods for high-dimensional genome-enabled prediction, with the advantage of its potential ability of capturing non-linear relationships, which may be useful in the study of quantitative traits under complex gene action.


PMID: 21481292

DOI: 10.1017/S0016672310000662

Other references

Butler, S.H., 1991: Pharmacologic treatment of low back pain. This article provides basic pharmacologic and behavioral principles and facts to simplify drug therapy for low back pain. It outlines basic protocols for symptom control while definitive treatments are beginning or healing occurs.

Piechowska, M.; Shugar, D., 1965: Replacement of 5-methyluracil (thymine) by 5-ethyluracil in bacterial DNA. Biochemical and Biophysical Research Communications 20(6): 768-773

Quick, J.; Williams, S.; Addison, S., 2010: Surgical care practitioners...our experience. Julie Quick and Sarah Williams--surgical care practitioners and Sarah Addison--consultant surgeon, present their own experiences of the surgical care practitioner (SCP) role and answer the question posed by Kim Sayers (pseudonym): 'Surgical c...

Trejo, F.M.; Rusconi, M.E.; Guzzetti, L.; Zamboni, M.I.; Guardati, M.C.; Lejona, S.; Pérez, P.F., 2011: Comparison of diagnostic methods for Clostridium difficile-associated diarrhea. In order to compare different methods for the diagnosis of Clostridium difficile-associated diarrhea, fecal filtrates from patients presenting symptoms compatible with this condition, were analyzed. Biological activity on Vero cells (biological as...

Yokoyama Y., 1987: Absolute dating of the site of genay in bourgogne france by the thorium 230 uranium 234 and protactinium 231 uranium 235 methods using gamma ray spectrometry. An animal bone is dated by gamma-ray spectrometry for the purpose of dating the Neandertalian remains of the Breche de Genay (Cote-d'Or, France). With this technique, the age of a sample can be obtained by the two independent methods: 230Th/2...

Pfeffer, M.G.; Pehlken, C.; Staehle, R.; Sorsche, D.; Streb, C.; Rau, S., 2014: Supramolecular activation of a molecular photocatalyst. The effects of the planar aromatic organic molecules anthracene and pyrene on the catalytic performance of the intramolecular hydrogen evolving photocatalyst [Ru(tbbpy)2(tpphz)PdCl2](PF6)2 functioning as a photocatalytic dyad have been studied. (1...

Cheung, Y.Bun.; Goh, C.; Thumboo, J.; Khoo, K-Siong.; Wee, J., 2006: Quality of life scores differed according to mode of administration in a review of three major oncology questionnaires. To assess whether scores on the three major quality-of-life questionnaires in oncology (FACT-G, FLIC, and EORTC QLQ-C30) are associated with modes of administration in a realistic clinical research setting. A heterogeneous sample of 1,265 cancer p...

Bourgogne, J., 1954: Un Oreopsyche nouveau du Portugal et de l'Espagne (Psychidae). Revue Francaise de Lepidopterologie Paris, 14: 133-137

Cornblatt, B.A.; Risch, N.J.; Faris, G.; Friedman, D.; Erlenmeyer-Kimling, L., 1988: The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Thirty families, consisting of two parents and two adolescent children, were tested on a high-processing load Continuous Performance Test, the CPT-IP, which required identification of identical stimulus pairs within a continuously presented series...

Rozé, J.; Babu, Séphanie.; Saffarzadeh, A.; Gayet-Delacroix, M.; Hoornaert, A.; Layrolle, P., 2009: Correlating implant stability to bone structure. The aim of this study was to demonstrate a possible correlation between bone microarchitecture and primary implant stability. Twenty-two implants (Ankylos((R)) and Straumann((R))) were inserted into the maxillae and mandibles of human cadavers. Bo...