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Prediction of gene phenotypes based on GO and KEGG pathway enrichment scores


, : Prediction of gene phenotypes based on GO and KEGG pathway enrichment scores. Biomed Research International 2013: 870795-870795

Observing what phenotype the overexpression or knockdown of gene can cause is the basic method of investigating gene functions. Many advanced biotechnologies, such as RNAi, were developed to study the gene phenotype. But there are still many limitations. Besides the time and cost, the knockdown of some gene may be lethal which makes the observation of other phenotypes impossible. Due to ethical and technological reasons, the knockdown of genes in complex species, such as mammal, is extremely difficult. Thus, we proposed a new sequence-based computational method called kNNA-based method for gene phenotypes prediction. Different to the traditional sequence-based computational method, our method regards the multiphenotype as a whole network which can rank the possible phenotypes associated with the query protein and shows a more comprehensive view of the protein's biological effects. According to the prediction result of yeast, we also find some more related features, including GO and KEGG information, which are making more contributions in identifying protein phenotypes. This method can be applied in gene phenotype prediction in other species.

US$19.90

PMID: 24312912

DOI: 10.1155/2013/870795


Other references

Thinus Blanc C., 1981: Volume discrimination learning in golden hamsters mesocricetus auratus effects of the structure of complex rearing cages. Golden hamsters (M. auratus) were reared from birth to adulthood in a spatially diversified situation (EG); their performances were compared with those of other hamsters housed in standard laboratory cages (SG). The task was to discriminate betwee...

Laverack, M.S., 1963: Responses Of Cuticular Sense Organs Of The Lobster, Homarus Vulgaris (Crustacea). Iii. Activity Invoked In Sense Organs Of The Carapace. Comparative Biochemistry and Physiology 10: 261-272

Renner, R., 1998: EPA decision to revise selenium standard stirs debate. The EPA has begun the process of revising its water standard for selenium in water. Although no decision has been made about the new standard, academic and non-EPA government biologists have suggested that the current standard of 5 parts per billi...

Webster G.D.; Lane N.G., 1987: Crinoids from the anchor limestone lower mississippian of the monte cristo group southern nevada usa. A silicified crinoid fauna from the Anchor Limestone of the Monte Cristo Group (Lower Mississippian) is described. Specimens are from the Meadow Valley Range of southern Nevada and adjacent areas. The fauna is primarily from the upper and lower me...

Saxena, V.; Manos, M.M.; Yee, H.S.; Catalli, L.; Wayne, E.; Murphy, R.C.; Shvachko, V.A.; Pauly, M.P.; Chua, J.; Monto, A.; Terrault, N.A., 2014: Telaprevir or boceprevir triple therapy in patients with chronic hepatitis C and varying severity of cirrhosis. Risks and benefits of protease inhibitor (PI) (telaprevir or boceprevir) triple therapy in hepatitis C virus (HCV)-infected patients with mildly decompensated cirrhosis, including those wait-listed for liver transplantation (LT), are incompletely...

Delrio, C.A., 1963: Pulmonary Emboli And Embolism. El Dia Medico 35: 1845-1853

Sigwald, J.P.; Lequenne, D.; Toussaint, G., 1981: Analysis of technical and economic results of farms with goat units. Data collected from 80-100 goat herds in France in 1973, 1976 and 1981 were analysed by various statistical techniques. Study of correlations indicated that milk output was closely correlated with cereal intake and with feeding costs. Discriminant...

Certad, G.; Ngouanesavanh, T.; Guyot, K.; Gantois, N.; Chassat, T.; Mouray, A.; Fleurisse, L.; Pinon, A.; Cailliez, J-Charles.; Dei-Cas, E.; Creusy, C., 2007: Cryptosporidium parvum, a potential cause of colic adenocarcinoma. Cryptosporidiosis represents a major public health problem. This infection has been reported worldwide as a frequent cause of diarrhoea. Particularly, it remains a clinically significant opportunistic infection among immunocompromised patients, ca...

Gutiérrez, J.C.; Amaro, F.; Martín-González, A., 2009: From heavy metal-binders to biosensors: ciliate metallothioneins discussed. Metallothioneins (MTs) are ubiquitous proteins with the capacity to bind heavy metal ions (mainly Cd, Zn or Cu), and they have been found in animals, plants, eukaryotic and prokaryotic micro-organisms. We have carried out a comparative analysis of...

Price, E.W.; Lehmann, W.F., 1978: Current flaking practices and their effect on board properties. The mechanical and physical properties are compared of flakeboards (exterior particleboards, waferboards, and structural flakeboards) made from flakes of 3 species (Pinus taeda, P. contorta, and Liquidambar styraciflua) cut on 4 types of equipment...