geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pregnancy outcome in women with multiple sclerosis: results from a prospective nationwide study in Finland


, : Pregnancy outcome in women with multiple sclerosis: results from a prospective nationwide study in Finland. Multiple Sclerosis 16(8): 950-955

The majority of individuals obtaining the diagnosis of multiple sclerosis are women of childbearing age. They are naturally concerned as to how multiple sclerosis affects the course of pregnancy and the developing foetus. The objective of this study was to prospectively evaluate the incidence of pregnancy complications and delivery risks, and to follow the natural course of multiple sclerosis during and after pregnancy in a cohort of Finnish patients with multiple sclerosis. Sixty-one patients with multiple sclerosis who became pregnant during the years 2003-2005 were prospectively followed-up from early pregnancy until 6 months postpartum. Multiple sclerosis relapses, Expanded Disability Status Scale rates and obstetric details were recorded. The results were compared with the statistics obtained from Finnish Medical Birth Register from the year 2004. We found that patients with multiple sclerosis were no more likely to experience pregnancy complications than Finnish pregnant women generally, but they had a greater likelihood for a need of artificial insemination (4.9% vs. 0.9%; p = 0.0009). Subjects with multiple sclerosis were more likely to undergo assisted vaginal delivery than the at-large cohort (16.4% vs. 6.5%; p = 0.0017). We conclude that pregnancy does not seem to pose a woman with multiple sclerosis to a greater risk for pregnancy complications when compared with women in general. The potential need for instrumental delivery should, however, be taken into account when planning the delivery of a mother with multiple sclerosis.

US$19.90

PMID: 20542921

DOI: 10.1177/1352458510372629


Other references

Novitskii, V.V.; Ryazantseva, N.V.; Vecherskii, Y.Yu.; Lapitskaya, O.I.; Stepovaya, E.A., 2004: Pathomorphosis of erythrocytes in patients with acquired valvular heart diseases and under conditions of their correction. Scanning electron microscopic study of the morphology and surface architectonics of erythrocytes in patients with acquired aortic and mitral valve diseases showed signs of morphological restructuring of the erythrocyte population. Reversibly trans...

Trainor, B., C.; Basolo, A., L., 2006: Location, location, location: stripe position effects on female sword preference. The evolution of complex signals via sexual selection is becoming a primary focus in mate choice studies. Male swordtail fish, Xiphophorus helleri, have a secondary sexual trait, the sword, which is a composite trait consisting of four components...

Fuchs, F., 1979: The relationship between pH and the amount of calcium bound to glycerinated muscle fibers. Variation of pH over the range 6.2--7.4 had no effect on the Ca2+ titration curve of glycerinated rabbit psoas muscle fibers. Thus the effect of H+ on muscle contraction is not due to a simple H+-Ca2+ competition for binding sites.

Smith, A.B.; Wright, P.; Selby, P.J.; Velikova, G., 2007: A Rasch and factor analysis of the Functional Assessment of Cancer Therapy-General (FACT-G). Although the Functional Assessment of Cancer Therapy--General questionnaire (FACT-G) has been validated few studies have explored the factor structure of the instrument, in particular using non-sample dependent measurement techniques, such as Rasc...

Henson, P.M., 1977: Activation of rabbit platelets by platelet-activating factor derived from IgE-sensitized basophils. Characteristics of the aggregation and its dissociation from secretion. Platelet-activating factor (PAF) is liberated from antigen-stimulated, IgE-sensitized rabbit basophils and induces aggregation of platelets and secretion of their content of vasoactive amines. Experiments were performed to determine the relationsh...

Dehn, U.V., 1953: Timber floating on one of the most important Swedish river systems.. Discusses organization, maintenance of channels timber sorting, labour and costs on the Umea/Vindelalven floating system.

Henriques, J.P.S.; Bouma, B.J.; Kloek, J.J., 2005: Images in cardiology. Dizziness and dyspnoea: psychiatry and cardiology. Heart 92(1): 57-57

Rozinova, N.N.; Deeva, M.M.; Dubovik, N.F., 1967: Oxygen deficiency in children with bronchial asthma. Voprosy Okhrany Materinstva i Detstva 12(7): 36-40

Raveh, J.; Vuillemin, T., 1990: Subcranial-supraorbital and temporal approach for tumor resection. The advantages of the subcranial over the transcranial approach for fronto-orbital tumor resection and subcranial exposure of the skull base are described in this paper. The primary reconstruction and fixation of the bone grafts with miniplates or...

Mege, J.L.; Olmer, M.; Purgus, R.; Bertocchio, P.; Farnarier, C.; Kaplanski, S.; Capo, C.; Bongrand, P., 1991: Haemodialysis membranes modulate chronically the production of TNF alpha, IL1 beta and IL6. As cytokines may play a role in the adverse effects of haemodialysis, TNF alpha, IL1 beta and IL6 were investigated before the haemodialysis session (chronic effect) and after 30 and 60 min (session effect). We found that haemodialysis exerts a ch...