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Primary amine stabilization of a dicopper(III) bis(μ-oxo) species: modeling the ligation in pMMO

, : Primary amine stabilization of a dicopper(III) bis(μ-oxo) species: modeling the ligation in pMMO. Journal of the American Chemical Society 136(41): 14405-8

Here we report the formation of the first examples of dicopper(III) bis(μ-oxo) complexes ligated by the primary amines, propylenediamine, and N,N,-dimethyl propylenediamine. Stabilization of these new compounds is effected at -125 °C by "core capture"- introduction of exogenous ligand to a preformed dicopper(III) bis(μ-oxo) complex supported by the peralkylated tetramethyl propylenediamine. Primary amine ligation in these compounds matches the single primary amine coordination of the putative active site of particulate methane monooxygenase (pMMO) and polysaccharide monooxygenase. Reactivity studies presented here show primary amine ligated cores are competent oxidants, capable of activating C-H bonds by an H-atom abstraction mechanism. Trends in spectroscopy, structure, and reactivity provide hints to the potential role of primary amine ligation in pMMO: increased substrate accessibility to the redox active orbitals of the Cu2O2 core and greater stabilization of the oxidant without attenuation of oxidizing power.


PMID: 25268334

DOI: 10.1021/ja508630d

Other references

Ali, J.; Wood, L.D., 1986: Factors affecting perfusion distribution in canine oleic acid pulmonary edema. Factors affecting perfusion distribution in oleic acid pulmonary edema were examined in 28 anesthetized open-chest dogs. Sixteen had unilobar oleic acid edema produced by left lower lobe pulmonary artery infusion of 0.03 ml/kg of oleic acid, and 1...

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Gad, A., 1979: Mucin histochemistry and questions in gastroenterology. A group of modern mucosubstance histochemical techniques was employed on normal and pathological specimens obtained from the gastrointestinal tract of 2212 individuals. In the light of the results, five main problems in the filed of gastroenterolo...