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Primary subcutaneous panniculitis-like T-cell cutaneous lymphoma: clinical presentation, treatment and prognosis

, : Primary subcutaneous panniculitis-like T-cell cutaneous lymphoma: clinical presentation, treatment and prognosis. Zhonghua Zhong Liu Za Zhi 32(5): 350-353

To explore the clinical presentation, treatment and prognosis study of primary subcutaneous panniculitis-like T-cell cutaneous lymphoma (SCPTCL). Ten cases of SCPTCL, treated in our hospital from January 1999 to January 2009, were included in this study. Their clinicopathological data were reviewed and analyzed retrospectively. the median age was 50.5 years (range: 10 - 58), 4 males and 6 females. There were seven CD56 positive, two negative cases and 1 unclear case. Four cases had repeatedly nodules regressed spontaneously without treatment before diagnosis and new nodules appeared at different sites. Seven patients presented with multiple subcutaneous nodules or deeply seated plaques, most commonly on the extremities and trunk. Ulceration of nodules occurred in 3 cases, and the lesions were painful in five cases. The lesions appeared nodules at the beginning, and then gradually grew into tumors. Four patients had abnormal liver function and one patient had hemophagocytic syndrome (HPS), four patients had lymphadenopathy or visceral involvement. Three cases with single lesion underwent surgical excision in combination with chemotherapy or chemotherapy/radiotherapy. One case lost follow up, and two cases live without disease. Among the seven patients with multiple lesions, lymphadenopathy or visceral involvement, one underwent local surgical excision and is alive without disease, six of them received chemotherapy or multi-modality treatment mainly with chemotherapy. Three of these 6 cases are alive without progression, one used histone deacetylase inhibitors after progression and obtained partial regression, and 2 died. The median follow-up for all the 10 patients was 44 months (range: 14 - 99). The progression free survival was 66.7% (6/9), and overall survival was 77.8% (7/9). SPTCL has an indolent course, some lesions can regress spontaneously and relapse again. Patients with single lesion may live long-term without disease after multimodality therapy. Patients with multiple lesions or extracutaneous involvement are sensitive to CHOP-like regimen, but the duration of remission is short. Histone deacetylase inhibitors may be a promising drug in the treatment for SCPTCL relapse.


PMID: 20723432

Other references

Porterfield, J.R.; Factor, D.A.; Grant, C.S., 2009: Operative technique for modified radical neck dissection in papillary thyroid carcinoma. Papillary thyroid carcinoma is the most common endocrine malignancy. Recently, controversy has focused on the management of lymph node metastases, which represent approximately 90% of disease recurrences and may require considerable time, effort,...

Trigo Rocha F.; Hsu G.L.; Donatucci C.F.; Lue T.F., 1992: The role of cyclic adenosine monophosphate cyclic guanosine monophosphate endothelium and non adrenergic non cholinergic neurotransmission in canine penile erection. Journal of Urology 147(4 SUPPL): 237A

Schumann, G.B., 1985: Utility of urinary cytology in renal diseases. Seminars in Nephrology 5(3): 158-178

Recchini D.Lattes Z., 1989: Role changes in women at midlife in argentina. American Association Of Retired Persons Midlife And Older Women in Latin America And The Caribbean; Consulting Group Meeting, Washington, D C , Usa, October 18-20, 1988 Xi+424p Pan American Health Organization: Washington, D C , Usa; American Association Of Retired Persons: Washington, D C , Usa Illus Paper 346-353

Ziecik, A., 1976: Influence of erythropoiesis stimulation on manganese 54 distribution in rats. Rats were made cnemic by blood letting or they received s.c. injections of erythropoietic filtrate of anemized sheep plasma. Enhanced 54Mn incorporation into the erythrocytes and bone marrow was induced by stimulation of erythropoiesis. The raised...

Cragg, B.G., 1975: The development of synapses in the visual system of the cat. Synapses have been counted by electron microscopy and neurones by light microscopy through the depth of the visual cortex in a series of cats from 37 days gestation to adulthood. A few definite synapses are present as early as three weeks before b...

Aleksandrov, A.A., 1997: The goosander Mergus merganser in Sankt-Peterburg.. Russkii Ornitologicheskii Zhurnal Ekspress Vypusk 12: 21-22

Gibson, S.; Arondel, V.; Iba, K.; Somerville, C., 1994: Cloning of a Temperature-Regulated Gene Encoding a Chloroplast omega-3 Desaturase from Arabidopsis thaliana. Previous genetic evidence suggested that the fad8 and fad7 genes of Arabidopsis thaliana encode chloroplast membrane-associated omega-3 desaturases. A putative fad8 cDNA was isolated by heterologous hybridization using a gene encoding an endoplasm...

Kosheleva, N.G., 1958: Effect of hypothermia in pregnant animals and of aminazine administration on the course of pregnancy, labor and condition of offspring. Akusherstvo i Ginekologiia 34(5): 17-21

Miller, G.J.; Esnouf, M.P.; Burgess, A.I.; Cooper, J.A.; Mitchell, J.P., 1997: Risk of coronary heart disease and activation of factor XII in middle-aged men. Increased activity is known to be present in the extrinsic, intrinsic, and final common pathways of the hemostatic system in men at high risk of coronary heart disease (CHD), but the status of the contact system of coagulation in this condition is...