+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Probiotics and prebiotics: immunological and clinical effects in allergic disease

, : Probiotics and prebiotics: immunological and clinical effects in allergic disease. Nestle Nutrition Workshop Series. Paediatric Programme 64: 219-35; Discussion 235-8, 251-7

The intestinal microbiota plays an important role in immune development and may play a role in the development of allergic disorders. Manipulation of the intestinal microbiota may therefore offer an approach to the prevention or treatment of allergic diseases. Probiotics and prebiotics, used alone or together (synbiotics), can influence the intestinal microbiota and modulate immune responses in vitro and in vivo. Clinical studies suggest a potential role for selected probiotics (alone or in combination with prebiotics) in the prevention of atopic eczema. A prenatal component of treatment appears important for beneficial effects. Effects are dependent upon the specific bacteria and characteristics of the study population. One study reported beneficial effects for prebiotics in the prevention of eczema in high-risk infants, however, further studies are required to confirm this. The use of probiotics in the treatment of allergic disease is less promising. A Cochrane meta-analysis concluded that probiotics are not effective for the treatment of atopic dermatitis. Probiotic effects in the treatment of asthma and allergic rhinitis are conflicting. Probiotics, prebiotics and synbiotics offer potential treatments for the prevention of atopic eczema; however, there is currently insufficient evidence to recommend their use in clinical practice. Studies to clarify the optimal dose, bacterial species/strains, whether there is added benefit with synbiotics, the optimal timing for intervention, and the patient populations who would benefit most from such therapies are warranted.


PMID: 19710525

DOI: 10.1159/000235793

Other references

Schaeffel, D.; Staff, R.Hinrich.; Butt, H-Juergen.; Landfester, K.; Crespy, D.; Koynov, K., 2013: Fluorescence correlation spectroscopy directly monitors coalescence during nanoparticle preparation. Dual color fluorescence cross-correlation spectroscopy (DC FCCS) experiments were conducted to study the coalescence and aggregation during the formation of nanoparticles. To assess the generality of the method, three completely different processe...

Kelley, H., 1985: The war against hessian fly. Agricultural research US Department of Agriculture Agricultural Research Service 33(5): 10-13

Easton, A.; Arbuzova, J.; Turek, F.W., 2003: The circadian Clock mutation increases exploratory activity and escape-seeking behavior. Disturbances of circadian rhythms are associated with many types of mood disorders; however, it is unknown whether a dysfunctional circadian pacemaker can be the primary cause of altered emotional behavior. To test this hypothesis, male and female...

Venturato, C.; Pavan, P.Giovanni.; Forestiero, A.; Carniel, E.Luigi.; Natali, A.Nicola., 2015: Investigation of the biomechanical behaviour of articular cartilage in hindfoot joints. Numerical models represent a powerful tool for investigating the biomechanical behavior of articular cartilages, in particular in the case of complex conformation of anatomical site. In the literature, there are complex non-linear-multiphase model...

Zhang, W.-Jie; Christiansen, F., T.; Wu, X.; Abraham, L., J.; Giphart, M.; Dawkins, R., L., 1993: Organization and evolution of C4 and CYP21 genes in primates: Importance of genomic segments. The evolutionary relationship between two central major histocompatibility complex (MHC) genes, C4 and CYP21, was investigated by employing pulsed field gel electrophoresis (PFGE) and conventional restriction fragment length polymorphism (RFLP) an...

Sutter, R.N., 1995: Medicaid public notice regulation generates litigation. Healthcare Financial Management 49(3): 68-69

Riedinger, J.M.rc; Coudert, B.; Barillot, I.; Buffenoir, G.; Mayer, F.; Fargeot, P.; Cuisenier, J.; Guerrin, J., 1997: Clinical interest of estimation of the growth kinetics of ovarian primary recurrences by CA125 doubling time. The aim of this retrospective work was to study the clinical importance of growth rate determination for ovarian cancer primary recurrence in term of CA125 doubling time (dt). Fifty-one patients with epithelial ovarian carcinoma stage III of IV wh...

Sevimli, F.K.; Kozan, E.; Kose, M.; Eser, M., 2006: The prevalence of helminths according to faecal examination in sheep in Afyonkarahisar province. The prevalence of helminths in sheep in Afyonkarahisar, Turkey, was determined in 2004-2005. Faecal examination showed 79.15% (281/355) sheep were positive for helminths. Eggs of Trichostrongylidae, Moniezia, Dicrocoelium dendriticum, Trichuris an...

A.M.stafa, W.A.; Ayed, I.A., 1989: Comparison of various extractants for evaluating phosphorus availability to plants in Saudi Arabia soils. Distilled water, NaHCO3, NH4HCO3-DTPA and NH4F-HCl were used to determine extractable P in 22 Saudi Arabian soils. The P soil test values were correlated with various yield and P uptake parameters obtained from a greenhouse pot experiment using ma...

Gould, H.L., 1963: Rx cognac: for your health; a review of the therapeutic qualities of cognac. Medical Times 91: 692-699