+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer

, : Prognostic and predictive value of intact and cleaved forms of the urokinase plasminogen activator receptor in metastatic prostate cancer. Prostate 71(8): 899-907

The purpose of this study was to investigate the prognostic value of different forms of the urokinase receptor, uPAR, in serum from prostate cancer (PC) patients. The uPAR forms were measured in samples from 131 metastatic PC patients. These constituted a subset of patients included in a randomized clinical trial of treatment with total androgen blockade (TAB) versus polyestradiol phosphate (PEP). Pre-treatment serum levels of intact uPAR (uPAR(I-III)), intact plus cleaved uPAR (uPAR(I-III) + uPAR(II-III)) and domain I (uPAR(I)) were measured using time-resolved fluorescence immunoassays (TR-FIAs). High serum levels of each of the uPAR forms were significantly associated with short overall survival (OS). The prognostic impact was strongest in the TAB treated patients with all uPAR forms being statistically significant. In multivariate analysis, uPAR(I-III) + uPAR(II-III) was an independent prognostic factor in TAB treated patients (HR = 5.2, 95% confidence interval (CI): 2.5-10.6, P < 0.0001) but not in PEP treated patients (P = 0.40). In the entire study population, OS was similar in the two treatment groups. The survival analysis showed significant interactions between treatment modality and the level of either uPAR(I-III) or uPAR(I-III) + uPAR(II-III). High levels of uPAR(I-III) + uPAR(II-III) were found to be predictive of effect of PEP versus TAB treatment. Patients with uPAR(I-III) + uPAR(II-III) levels above the median had significantly longer OS (median difference 11.3 months), if treated with PEP rather than with TAB (HR = 1.8, 95% CI:1.1-3.1, P = 0.03). uPAR forms are significantly associated with OS. High uPAR(I-III) + uPAR(II-III) predicts longer OS in patients treated with PEP compared to TAB. uPAR forms are promising prognostic and predictive markers in PC.


PMID: 21456072

DOI: 10.1002/pros.21306

Other references

Schlogl, Thomas., 1996: The postembryonic development of male Branchipus schaefferi Die postembryonale Entwicklung der Mannchen des Feenkrebses Branchipus schaefferi. Stapfia. 15 Februar; 42: 137-148

Daskalakis, M.I.; Magoulas, A.; Kotoulas, G.; Catsikis, I.; Bakolas, A.; Karageorgis, A.P.; Mavridou, A.; Doulia, D.; Rigas, F., 2014: Pseudomonas, Pantoea and Cupriavidus isolates induce calcium carbonate precipitation for biorestoration of ornamental stone. Bacterially induced calcium carbonate precipitation from various isolates was investigated aiming at developing an environmentally friendly technique for ornamental stone protection and restoration. and ResultsMicroorganisms isolated from stone sa...

Valenta, Jaroslav, 1993: On some aspects of the structure of bone tissue and its remodelling. Valenta, J [Editor] Clinical Aspects of Biomedicine; Biomechanics 63-66

Stewart, B.A., 1967: Nitrogen-sulphur relationships in plant tissues, plant residues, and soil organic matter. A review with 16 references.

Dickinson, W.A., 1942: Haemolytic Anaemia in a Mare due to Sulphanilamide. A mare which had just given birth to a dead foal was given a total of 6 oz. of sulphanilamide, 3 oz. being given immediately after foaling, two 1 oz. doses the next day, and a single 1 oz. dose on the third day. She died during the evening of the...

Guinee P.; Kruyt B., 1975: Use of an isolator system to study the selective pressure of sulfaquinoxaline in containing coccidiostats on escherichia coli populations in chicks. Zentralblatt fuer Veterinaermedizin Reihe B 22(9): 718-728

Shankar, N.; Kennedy, S.D.; Chen, G.; Krugh, T.R.; Turner, D.H., 2006: The NMR structure of an internal loop from 23S ribosomal RNA differs from its structure in crystals of 50s ribosomal subunits. Internal loops play an important role in structure and folding of RNA and in recognition of RNA by other molecules such as proteins and ligands. An understanding of internal loops with propensities to form a particular structure will help predict...

Jaernefors Bjoern, 1955: Synpunkter pa kvartaera lerors genetik. An account is given of some stratigraphic and genetic problems of clays of the Uppsala region and the Goeta river valley, Sweden, with particular reference to the distribution of CaCO (sub 3) and sodium in the clays of the Uppsala region.

Heise, S.; Van Acker, A., 2000: The effect of social environment on the immune response of female common voles in matriarchal laboratory groups. We used the hemagglutination test to investigate differences in the specific immune response to sheep red blood cells (SRBC) of female common voles living in matriarchal groups. The applied test proved to be a useful tool for studying the effect o...

Eylar, E.H.; Hashim, G.A., 1969: Allergic encephalomyelitis: cleavage of the C-tryptophyl bond in the encephalitogenic basic protein from bovne myelin. Archives of Biochemistry and Biophysics 131(1): 215-222