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Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma

, : Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma. Hematological Oncology 27(1): 31-39

Classical Hodgkin Lymphoma (cHL) is morphologically characterized by a small number of tumour cells, Hodgkin and Reed-Sternberg (HRS) cells, surrounded by numerous tumour-infiltrating lymphocytes (TIL). The functional role of these TIL is still controversial. While generally considered to represent an anti-tumour immune response, TIL in cHL might result from the profoundly deregulated immunity of cHL patients. Eighty-seven cases of cHL were available to evaluate the prognostical significance of tumour-infiltrating cytotoxic T lymphocytes (CTL), T helper 1 (Th1) cells, T helper 2 (Th2) cells and regulatory T cells (Treg). We confirm that in cHL the microenvironment is dominated by Th2 cells and Treg and show that large numbers of Th2 cells are associated with significantly improved disease-free survival (p = 0.021) and event-free survival (p = 0.012). Furthermore, a high ratio of Treg over Th2 cells resulted in a significantly shortened disease-free survival (p = 0.025). These observations suggest that Treg may exert inhibitory effects on anti-tumour immune responses mediated through Th2 cells and that Th2 cells may be more important for effective anti-tumour immunity than anticipated.


PMID: 18924115

DOI: 10.1002/hon.878

Other references

Kaposi, P.B.nyai, L., 1980: Variety collection and gene bank as a precondition of drug plant breeding. Agrartudomanyi kozlemenyek9(1-2): 300-303

Cartreine, J.Albert.; Locke, S.E.; Buckey, J.C.; Sandoval, L.; Hegel, M.T., 2012: Electronic problem-solving treatment: description and pilot study of an interactive media treatment for depression. Computer-automated depression interventions rely heavily on users reading text to receive the intervention. However, text-delivered interventions place a burden on persons with depression and convey only verbal content. The primary aim of this pro...

Uluutku, H.; Can, M.A.; Kurtoglu, Z., 2000: Formation and location of the sural nerve in the newborn. In this study, the location and formation of the sural nerve were examined in 40 legs of new-born cadavers. The sural nerve was formed by the peroneal communicating branch from the common peroneal nerve joining the medial sural cutaneous nerve in...

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Manzo, J.; Vazquez, M.; Camacho, M.; Garcia, L.; Carrillo, P.; Hernandez, M.F.; Pacheco, P., 1996: Sexual behavior of adult male rats after postnatal treatment with capsaicin. Society for Neuroscience Abstracts 22(1-3): 1912

Krochmal, C., 1994: Anti-tumor activities of hive products. American bee journal 134(6): 420

Schmalhausen, I.I., 1959: Concerning monophyletism and polyphyletism in relation to the origin of land vertebrates. Byull Obshch. IsPrirod. (Biol. Sect.): 15-33

Zacherl, A.; Love, B.; McCorvey, R., 1997: Office laparoscopy under local anesthesia. It is no secret that health care has changed, and we must change with it. As equipment and drugs become more sophisticated, surgical procedures are becoming less complicated to perform, and patients are experiencing less morbidity and mortality. I...

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