+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prognostic role of epidermal growth factor receptor in nasopharyngeal carcinoma: a meta-analysis

, : Prognostic role of epidermal growth factor receptor in nasopharyngeal carcinoma: a meta-analysis. Head & Neck 36(10): 1508-1516

Various studies have assessed the prognostic value of epidermal growth factor receptor (EGFR) overexpression in nasopharyngeal carcinoma (NPC), but their results remain controversial. Studies published up to January 2013 were collected. A total of 16 studies involving 1179 patients were reviewed. A meta-analysis was performed to clarify the prognostic role of EGFR in patients with NPC. The combined hazard ratio (HR) and 95% confidence interval (CI) were estimated using fixed-effects or random-effects models. EGFR overexpression had significantly poor effect on overall survival (OS; HR, 1.86; 95% CI, 1.25-2.77), disease-free survival (DFS; HR, 2.25; 95% CI, 1.66-3.04) and locoregional control (HR, 2.93; 95% CI, 1.71-5.02). However, the association between EGFR overexpression and distant metastasis-free survival was not statistically significant (HR, 1.39; 95% CI, 0.72-2.67). EGFR overexpression can be a prognostic factor for patients with NPC.


PMID: 23996630

DOI: 10.1002/hed.23481

Other references

Neff, Richard D., 1959: The quantitative evaluation of factors in measurement of Sr90 burden of live rats. The quantitative evaluation of factors in measurement of Sr90 burden of live rats 44p

Stevanović, V.; Vukasinović, Z.; Spasovski, D., 2006: Ewing sarcoma--analysis of epidemiological parameters and their relation to clinical characteristics. The purpose of this investigation was to evaluate epidemiologic features of Ewing sarcoma in children treated in the Institute for Orthopedic Surgery "Banjica: as well as to establish relation of these features to clinical findings. Study inv...

Mohr, A.J.; Leisewitz, A.L.; Jacobson, L.S.; Steiner, J.M.; Ruaux, C.G.; Williams, D.A., 2001: Effect of early enteral nutrition on intestinal permeability, intestinal protein loss, and outcome in dogs with parvovirosis. Journal of Veterinary Internal Medicine 15(3): 275, May-June

Cassells, A.C.; Barlass, M., 1978: A method for the isolation of stable mesophyll protoplasts from tomato leaves throughout the year under standard conditions. Plants are grown in the equivalent of spring and winter light intensities (15 h day and incoming solar radiation 2.52 to 10.8 MJ/m2/day) in the glasshouse on peat compost supplied with a balanced fertilizer containing nitrate and urea and given a...

Pignero, A.; Stefanini, A., 1950: 7 More cases of hemolytic disease of the newborn. Il Lattante 21(10): 663-669

Pauna, H.Furlan.; Carvalho,; Guimarães, A.Caixeta.; Maunsell, R.Christina.Kathleen.; Sakano, Eália., 2013: Schwannoma of the nasal septum: evaluation of unilateral nasal mass. Brazilian Journal of Otorhinolaryngology 79(3): 403-403

Hsu, P.K. et al., 1987: Surveillance of the chief vectors of tsutsugamushi in breeding places of Guangzhou area (with checklist of scrub mites). The checklist comprises the following species: Walchia chinensis, W. pacifica, W. parapacifica, Gahrliepia yangchenensis, G. romeri, Schoengastia pseudoschueffneri, S. cantonensis, S. longdongensis, Euschoengastia indica, Eutrombicula wichmanni, L...

Livingston, P.A.; Methot, R.D., 1998: Incorporation of predation into a population assessment model of eastern Bering Sea walleye pollock. Funk, F [Editor], Quinn, T J , II [Editor], Heifetz, J [Editor], Ianelli, J N [Editor], Powers, J E [Editor], Schweigert, J F [Editor], Sullivan, P J [Editor], Zhang, C -I [Editor] Lowell Wakefield Fisheries Symposium Series; Fishery stock assessment models 663-678

Romaniuk, K., 1973: New faecal method for the diagnosis of fascioliasis in cattle. A modified decantation method suitable for the routine diagnosis of fascioliasis in cattle is described. It is claimed that this method is faster, easier to carry out and nearly 100% efficient, even for the detection of a single Fasciola hepatica...

Racine, S.E.; Burt, S.Alexandra.; Keel, P.K.; Sisk, C.L.; Neale, M.C.; Boker, S.; Klump, K.L., 2016: Examining associations between negative urgency and key components of objective binge episodes. Negative urgency (NU; tendency to act impulsively when experiencing negative emotions) is a risk factor for binge eating, although few studies have examined interviewer-assessed objective binge episodes (OBEs). Moreover, research has not investiga...