geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prognostic value of grading masticator space involvement in nasopharyngeal carcinoma according to MR imaging findings


, : Prognostic value of grading masticator space involvement in nasopharyngeal carcinoma according to MR imaging findings. Radiology 273(1): 136-143

To derive a suitable method for grading masticator space invasion in nasopharyngeal carcinoma on the basis of magnetic resonance (MR) images and to determine its prognostic value in patients undergoing intensity-modulated radiation therapy. After institutional review board approval and informed consent were acquired, 808 patients with nasopharyngeal carcinoma who were treated with definitive intensity-modulated radiation therapy were analyzed retrospectively. The anatomic sites of masticator space involvement were identified with MR imaging. Overall survival, local relapse-free survival, and distant metastasis-free survival were calculated by using the Kaplan-Meier method and were compared by using the log-rank test. Potential prognostic factors were identified by means of multivariate analysis. Masticator space involvement was diagnosed in 163 of 808 patients (20.2%). Patients with lateral invasion (involvement of the lateral pterygoid muscle of the masticator space and beyond) had significantly poorer overall survival and distant metastasis-free survival than those with medial invasion (involvement of the medial pterygoid muscle of the masticator space) (P = .035 and P = .026, respectively). Furthermore, their overall survival, local relapse-free survival, and distant metastasis-free survival were significantly poorer compared with patients with stage T2 or T3 disease (all P ≤ .023) but similar to patients with stage T4 disease. The grade of masticator space involvement was an independent prognostic factor for overall survival, local relapse-free survival, and distant metastasis-free survival (all P ≤ .023). Masticator space involvement in nasopharyngeal carcinoma should be graded as medial (stage T2 disease) or lateral (stage T4 disease). This can facilitate staging of nasopharyngeal carcinoma and may be a suitable prognostic indicator of survival.

US$19.90

PMID: 24844470

DOI: 10.1148/radiol.14132745


Other references

Aleixo, P.L., 1966: G 27202 in acute and chronic adnexal disorders and in toco-gynecological surgery. Revista Brasileira de Medicina 23(3): 188-189

Armstrong, D.K.; McKenna, K.E.; Purkis, P.E.; Green, K.J.; Eady, R.A.; Leigh, I.M.; Hughes, A.E., 1999: Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma. Desmosomes are highly organized intercellular adhesive junctions that are particularly prominent in epidermis and other tissues experiencing mechanical stress. Desmoplakin, a constitutive component of the desmosomal plaque, is the most abundant pr...

Podolyan V.I., 1984: The regularities of distribution of coal basins and deposits of the Pacific mobile belt (USSR)--Zakonomernosti razmeshcheniya ugol'nykh basseynov i mestorozhdeniy Tikhookeanskogo podvizhnogo poyasa na territorii SSSR. International Geological Congress, Abstracts = Congres Geologique International, Resumes: ol. IX, Part 2, Pages 312-314. 1984.

Sabrosky, C.W.; Braun, B.H., 1970: A tachinid parasite of fireflies (Diptera, Tachinidae, Coleoptera, Lampyridae). Ent. News, 81: 185-187

Furchner, J.E.; Richmond, C.R., 1962: Effect of stable cesium on the retention of cesium137 by rats. Male rats 84 days old, 34 in 3 groups, were fed on commercial rat diet which spectrographic analysis showed to contain 6.5 X 10-5% Cs. Stable Cs as chloride was added to the diet of the 3 groups to a final concentration of 6.5 x 10-4, 6.5 x 10-3 a...

Graham, J.D.; Katib H.A.L., 1967: Adrenolytic and sympatholytic properties of 2-halogenoalkylamines in the vas deferens of the guinea-pig. Many adrenolytic drugs possess feeble sympatholytic properties and the 2-halogeno-alkylamines are no exception. In the guniea-pig vas deferens stimulated via the hypogastric nerve or transmurally noradrenaline [norepinephrine] (SY28 [2-(N-benzyl-2...

Merinero, B.; Pérez-Cerdá, C.; Garcia, M.J.; Chadefaux-Vekemans, B.; Kamoun, P.; Tonetti, C.; Zittoun, J.; Jakobs, C.; Ugarte, M., 1998: Reliability of biochemical parameters used in prenatal diagnosis of combined methylmalonic aciduria and homocystinuria. Prenatal diagnosis for combined methylmalonic aciduria and homocystinuria was performed in five at-risk pregnancies by determination of methylmalonic acid (MMA) and total homocysteine (Hcy) in amniotic fluid supernatant. The incorporation rate of...

Lipsic, E.; Van Der Meer, P.; Suurmeijer, A.J.H.; Schoemaker, R.G.; Van Veldhuisen, D.J.; Van Gilst, W.H.; Henning, R.H., 2003: Erythropoietin protects against ischaemic damage in isolated rat heart. European Heart Journal 24(Abstract Supplement): 477, August-September

Ross, J.G.; Todd, J.R., 1965: Biochemical, Serological And Haematological Changes Associated With Infections Of Calves With The Nematode Parasite, Ostertagia Ostertagi. Calves with heavy natural and experimental infections of Ostertagia ostertagi when compared with parasite-free calves were characterized by low serum albumin levels (1.3 to 1.6 g/100 ml), hemoconcentration, and high pH and low pepsin concentration...

Harper, J., 1955: The influence of the environment on seed and seedling mortality. 6. The effects of the interaction of soil moisture content and temperature on the mortality of maize grains. Maize grains were exposed to 16-20 combinations of soil moisture and soil temperature (1-30 degrees C.) for varying periods of time. Grains germinated readily in the wettest soils at 30 and 20 degrees C., but germination was inhibited at the lower...