+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prognostic value of serum 25-hydroxyvitamin D in patients with stroke

, : Prognostic value of serum 25-hydroxyvitamin D in patients with stroke. Neurochemical Research 39(7): 1332-1337

We aimed to evaluate the association between 25-hydroxyvitamin D [25(OH) D] levels and both clinical severity at admission and outcome at discharge in patients with acute ischemic stroke (AIS). From June 2012 to October 2013, consecutive first-ever AIS patients admitted to the Department of Emergency of The Fourth Affiliated Hospital of Harbin Medical University, China were identified. Clinical information was collected. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome was evaluated at discharge using the modified Rankin scale (m-Rankin). Multivariate analyses were performed using logistic regression models. During the study period, 326 patients were diagnosed as AIS and were included in the analysis. Serum 25(OH) D levels reduced with increasing severity of stroke as defined by the NIHSS score. There was a negative correlation between levels of 25(OH) D and the NIHSS (r = - 0.389, P = 0.000). In multivariate analyses, serum 25(OH) D level was an independent prognostic marker of discharge favorable functional outcome and survival [odds ratio 3.96 (2.85-7.87) and 3.36 (2.12-7.08), respectively, P = 0.000 for both, adjusted for NHISS, other predictors and vascular risk factors] in patients with AIS. Serum 25(OH) D levels are a predictor of both severity at admission and favorable functional outcome in patients with AIS. Additional research is needed on vitamin D supplementation to improve the outcome of post-stroke patients.


PMID: 24789365

DOI: 10.1007/s11064-014-1316-0

Other references

Kolle, K., 1964: Unusual Cranial Nerve Syndromes. Munchener Medizinische Wochenschrift 106: 2181-2182

Scheldeman, S., 1961: Loslopende reptielen. Lacerta, 19(12)

Hameed, A.S.S.; Parameswaran, V.; Musthaq, S.S.; Sudhakaran, R.; Balasubramanian, G.; Yoganandhan, K., 2005: A simple PCR procedure to detect white spot syndrome virus (WSSV) of shrimp, Penaeus monodon (Fabricious). A non-stop, single tube and semi-nested polymerase chain reaction (PCR) technique with simple procedure was developed for simultaneous detection and grading the level of white spot syndrome infection in penaeid shrimp, Penaeus monodon. In this PCR...

Moon, D.-Gyung; Mizutani, F., 2007: Partitioning pattern of C-13-assimilates in different portions of maturing satsuma mandarin fruit. After feeding (CO2)-C-13 to satsuma mandarin (Citrus unshiu cv. Okitsu) leaves, the time-course changes in the C-13 content of various parts (juice, pulp, and peel) of maturing fruit were monitored in the axial direction (stem end, mid section, a...

Van Dijken J.P.; Harder W.; Quayle J.R., 1981: Energy transduction and carbon assimilation in methylotrophic yeasts. Dalton, H (Ed ) Microbial Growth on C1 Compounds; Proceedings Of The 3rd International Symposium, Sheffield, England, Aug 12-16, 1980 Xiii+377p Heyden And Son Ltd : London, England; Philadelphia, Pa , Usa Illus Paper P191-201

Thakor, A.S.; Giussani, D.A., 2004: Calcitonin gene-related peptide contributes to the umbilical haemodynamic defence response to acute hypoxaemia. Despite clinical advances in obstetric practice, undiagnosed fetal hypoxaemia still contributes to a high incidence of perinatal morbidity. The fetal defence to hypoxaemia involves a redistribution of blood flow away from peripheral circulations t...

Shah, D.M.; Langley, C.H., 1979: Inter- and intraspecific variation in restriction maps of Drosophila mitochondrial DNAs. Nature 281(5733): 696-699

Nanot, Sébastien.; Avriller, Rémi.; Escoffier, W.; Broto, J-Marc.; Roche, S.; Raquet, B., 2010: Propagative Landau states and Fermi level pinning in carbon nanotubes. We present strong evidence of Landau states formation in multiwalled carbon nanotubes with metallic or semiconducting outer shells, under magnetic fields as high as 60 T. Magnetoconductance data are found to converge to a gate-independent value fo...

Vernadsky V.I., 1938: Radio-geology and its significance. Radioactive elements as indicators of geologic time.

Arai T.; Mizuno K.; Fujikawa A.; Nakagawa M.; Kikuchi M., 1990: Ir absorption spectra ranging from 25 to 10 micrometer at various layers of human normal abdominal aorta and fibrofatty atheroma in vitro. Lasers in Surgery & Medicine 10(4): 357-362