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Proniosomes as a carrier system for transdermal delivery of tenoxicam

, : Proniosomes as a carrier system for transdermal delivery of tenoxicam. International Journal of Pharmaceutics 405(1-2): 142-152

Tenoxicam is a non steroidal anti-inflammatory drug (NSAID) widely used in the treatment of rheumatic diseases and characterized by its good efficacy and less side effects compared to other NSAIDs. Its oral administration is associated with severe side effects in the gastrointestinal tract. Transdermal drug delivery has been recognized as an alternative route to oral delivery. Proniosomes offer a versatile vesicle delivery concept with the potential for drug delivery via the transdermal route. In this study, different proniosomal gel bases were prepared, characterized by light microscopy, revealing vesicular structures, and assessed for their drug entrapment efficiency, stability, their effect on in vitro drug release and ex vivo drug permeation. The lecithin-free proniosomes prepared from Tween 20:cholesterol (9:1) proved to be stable with high entrapment and release efficiencies. The in vivo behaviour of this formula was studied on male rats and compared to that of the oral market product. The investigated tenoxicam loaded proniosomal formula proved to be non-irritant, with significantly higher anti-inflammatory and analgesic effects compared to that of the oral market tenoxicam tablets.


PMID: 21129461

DOI: 10.1016/j.ijpharm.2010.11.003

Other references

Antosiewicz, M.; Bromboszcz, I., 1967: A case of Martin de Gimard syndrome in an 7-month-old child. Przeglad Lekarski 23(5): 463-464

Beliakov, V.D.; Khokhlov, D.T., 1981: Prospects for developing immunoprophylaxis among the troops. Voenno-Meditsinskii Zhurnal: 48-51

Vogelgesang, S.A.; Dennis, G.J.; Bauer, F.A., 1993: Proteinuria associated with tolmetin treatment in a patient with systemic lupus erythematosus. Arthritis and Rheumatism 36(8): 1181-1182

Bell, G.I.; Merryweather, J.P.; Sanchez-Pescador, R.; Stempien, M.M.; Priestley, L.; Scott, J.; Rall, L.B., 1984: Sequence of a cDNA clone encoding human preproinsulin-like growth factor II. The insulin-like growth factors (IGF) I and II are single-chain serum proteins of 70 and 67 amino acids, respectively, which are synthesized by the liver and possibly other tissues. They are probably required for normal fetal and postnatal growth...

Blakemore, W.F., 1974: Remyelination of the superior cerebellar peduncle in old mice following demyelination induced by cuprizone. Journal of the Neurological Sciences 22(1): 121-126

Shames, S.R.; Croxen, M.A.; Deng, W.; Finlay, B.Brett., 2012: The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17b. Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively) are attaching and effacing (A/E) bacterial pathogens that cause severe diarrheal disease worldwide. To cause disease, A/E pathogens require a type III secretion...

Rabbinge, R., 1984: Crop losses in crop physiological and crop ecological terms and their implication for pest management. In this paper, the value of plant protection measures at different levels of crop production are discussed and the possibilities of and necessity for sophisticated pest and disease management systems are considered. Particular reference is made to...

Wilkins, J., 2015: The use of cognitive reappraisal and humour as coping strategies for bullied nurses. This article explores the repercussions of workplace bullying on nurses and the health-care profession as a whole. I discuss the nature of workplace bullying and draw upon prior studies to explore some of the barriers that prevent witnesses to bul...

Carson, P.J.; Nichol, K.L.; O'Brien, J.; Hilo, P.; Janoff, E.N., 2000: Immune function and vaccine responses in healthy advanced elderly patients. Background: Decline in immune function has been reported to predictably accompany advancing age. However, to our knowledge, few studies have specifically characterized the rapidly expanding advanced elderly population or controlled adequately for...

Reichart, T.M.; Baksh, M.M.; Rhee, J-Kyu.; Fiedler, J.D.; Sligar, S.G.; Finn, M.G.; Zwick, M.B.; Dawson, P.E., 2016: Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding. The membrane-proximal external region (MPER) of HIV gp41 is an established target of antibodies that neutralize a broad range of HIV isolates. To evaluate the role of the transmembrane (TM) domain, synthetic MPER-derived peptides were incorporated...