+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prospective study of statin use and risk of Parkinson disease

, : Prospective study of statin use and risk of Parkinson disease. Archives of Neurology 69(3): 380-384

To prospectively examine whether use of statins is associated with altered risk of Parkinson disease (PD). A prospective study including 38 192 men and 90 874 women participating in 2 ongoing US cohorts, the Health Professional Follow-up Study and the Nurses' Health Study, was conducted. Information on regular cholesterol-lowering drug use (≥2 times/wk) was collected in 1994 in both cohorts via questionnaire. Relative risks (RRs) and 95% CIs were computed using Cox proportional hazards models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. Incident PD. During 12 years of follow-up (1994-2006), we documented 644 incident PD cases (338 women and 306 men). The risk of PD was lower among current statin users (adjusted pooled RR = 0.74; 95% CI, 0.54-1.00; P = .049) relative to nonusers. A significant association was observed in participants younger than 60 years at baseline (adjusted pooled RR = 0.31; 95% CI, 0.11-0.86; P = .02) but not among those who were older (adjusted pooled RR = 0.83; 95% CI, 0.60-1.14; P = .25) (P for interaction = .03). We found that regular use of statins was associated with a modest reduction in PD risk. The possibility that some statins may reduce PD risk deserves further consideration.


PMID: 22410446

DOI: 10.1001/archneurol.2011.1060

Other references

Ebner, F.H.; Kleiter, M.; Danz, Sören.; Ernemann, U.; Hirt, B.; Löwenheim, H.; Roser, F.; Tatagiba, M., 2015: Topographic changes in petrous bone anatomy in the presence of a vestibular schwannoma and implications for the retrosigmoid transmeatal approach. The maneuver of transmeatal drilling carries the risk of injuring inner ear structures, which may cause immediate or delayed hearing loss. To describe the changes in petrous bone anatomy caused by the tumor and to analyze both the incidence and th...

Smith, R.E.; Dippe, D.W.; Miller, S.D., 1975: Phlyctenular keratoconjunctivitis: results of penetrating keratoplasty in Alaskan natives. Corneal scarring secondary to inactive phlyctenular keratoconjunctivitis (PKC) is a significant cause of decreased vision in Alaskan Natives. The results of primary penetrating keratoplasty for such cases at the Alaska Native Medical Center form t...

Scagliola, M.H., 1971: Mental and physical health in the American inner city. Lancet 2(7739): 1415-1417

Awad, A.M.; Shaker, A.Mohamad.; Zaki, A.Borhan.El-Din.; Nassr, L.Abdel-Mohsen.Ebaid., 2008: Novel mechanistic aspects on the reaction between low spin Fe(II) Schiff base amino acid complexes and hydrogen peroxide-spectrophotometric tracer of intraperoxo intermediate catalyzed reaction. The kinetics and mechanism of the reaction of hydrogen peroxide with some Fe(II) Schiff base complexes were investigated spectrophotometrically in aqueous solution at pH 8 and 35 degrees C under pseudo-first-order conditions. The used ligands were...

Rodríguez-Moreno, A.; Carrión, M.; Delgado-García, Jé.María., 2006: The nicotinic agonist RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801. The classical conditioning of eyelid responses using trace paradigms is a hippocampal-related model of associative learning, involving the activation of N-methyl-D-aspartate (NMDA) receptors. We have evaluated here the effects of NMDA-receptor blo...

Ricketts, T.H.; Dinerstein, E.; Olson, D.M., 1999: Who's where in North America?. Conservationists have proposed various criteria to identify areas of highest conservation priority, but species richness is usually the principle parameter. The prominence afforded to species richness arises because of the significance of so-calle...

Mussini Sergio, 1980: Geology of the Pavian Oltrepo. Quaderni della Sezione di Scienze Naturali - Civico Museo di Voghera, Gruppo Geo Paleontologico Vogherese 3(1): 9

Kinion, E.S., 2002: The beat of the drum. This article describes the development of a nurse-managed clinic in an urban environment. The clinic provides primary care services to persons who do not have health insurance. One primary population served is urban American Indians. Perceived bar...

Tibbitts, J.; Fike, J.R.; Kahl, S.B., 1997: Pharmacokinetics, toxicology and tissue distribution of a boronated porphyrin in dogs. Pharmaceutical Research (New York) 14(11 SUPPL ): S367, Nov

Oh, Y.Taek.; Lee, K-Mu.; Bari, W.; Kim, H.Young.; Kim, H.Jin.; Yoon, S.Sun., 2016: Cholera Toxin Production Induced upon Anaerobic Respiration is Suppressed by Glucose Fermentation in Vibrio cholerae. The causative agent of pandemic cholera, Vibrio cholerae, infects the anaerobic environment of the human intestine. Production of cholera toxin (CT), a major virulence factor of V. cholerae, is highly induced during anaerobic respiration with trim...