geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prospects for neurodegenerative and psychiatric disorder drug discovery


, : Prospects for neurodegenerative and psychiatric disorder drug discovery. Expert Opinion on Drug Discovery 6(5): 457-463

The discovery of CNS-active drugs has, to a major extent, resulted from clinical serendipity. Once targets for such compounds were identified, conventional mechanism-based approaches were used to identify new chemical entities for the treatment of neurological and psychiatric disorders. Most of these have, however, failed to display any greater efficacy than existing psychotherapeutics and may, in fact, be less efficacious because of side effect liabilities. Among the reasons for this lack of success in drug discovery include a lack of fundamental knowledge regarding the causes of CNS disorders, the absence of biomarkers for diagnosing and monitoring these conditions, a paucity of animal models that are congruent with the human disease state and the increasing likelihood that CNS conditions are multifactorial in their etiology. These challenges force the inclusion of a Phase IIa proof of concept trial as a component of the drug discovery program. Unlike other therapeutic areas, serendipity is a major factor in the CNS translational medicine interface requiring a close collaboration between preclinical and clinical scientists trained to appreciate unusual behavioral phenotypes. When combined with conventional target-based drug discovery technologies, this increases the likelihood of identifying truly novel drugs for the treatment of CNS disorders.

US$19.90

PMID: 22646072

DOI: 10.1517/17460441.2011.562497


Other references

Cooper, T.; White, C.L.; Taber, D.; Uber, W.E.; Kokko, H.; Mazur, J., 2013: Safety and effectiveness outcomes of an inpatient collaborative drug therapy management service for direct thrombin inhibitors. The impact of a collaborative drug therapy management (CDTM) agreement enabling pharmacist-managed direct thrombin inhibitor (DTI) therapy was evaluated. A retrospective chart review was conducted to compare selected outcome measures between cohor...

Shimpi, S.S.; Savant, N.K., 1975: Influence of sorbed cations on ammonia retention capacity of tropical soils. The NH3-retention capacity of the tropical soils, as influenced by sorbed cations followed the decreasing order: H-Soil approx equal to Al-Soil > Mg-Soil approx equal to Ca-Soil > Na-Soil approx equal to K-Soil > Check Soil.

Cara Fabrizio; Rovelli Antonio; D.G.ulio Giuseppe; Marra Fabrizio; Braun Thomas; Cultrera Giovanna; Azzara Riccardo; Boschi Enzo, 2005: The role of site effects on the intensity anomaly of San Giuliano di Puglia inferred from aftershocks of the Molise, Central Southern Italy, sequence, November 2002. The M (sub L) 5.4 Molise earthquake of 31 October 2002 caused damage of Mercalli-Cancani-Sieberg (MCS) intensity VIII-IX to the small town of San Giuliano di Puglia. In contrast, the other towns in the epicentral area did not exceed MCS intensity...

Kumar, R.; Seibold, M.A.; Aldrich, M.C.; Williams, L.Keoki.; Reiner, A.P.; Colangelo, L.; Galanter, J.; Gignoux, C.; Hu, D.; Sen, S.; Choudhry, S.; Peterson, E.L.; Rodriguez-Santana, J.; Rodriguez-Cintron, W.; Nalls, M.A.; Leak, T.S.; O'Meara, E.; Meibohm, B.; Kritchevsky, S.B.; Li, R.; Harris, T.B.; Nickerson, D.A.; Fornage, M.; Enright, P.; Ziv, E.; Smith, L.J.; Liu, K.; Burchard, E.González., 2010: Genetic ancestry in lung-function predictions. Self-identified race or ethnic group is used to determine normal reference standards in the prediction of pulmonary function. We conducted a study to determine whether the genetically determined percentage of African ancestry is associated with lu...

Carillon, J.; Barbé, F.; Barial, S.; Saby, M.; Sacy, A.; Rouanet, J-M., 2016: Diet supplementation with a specific melon concentrate improves oviduct antioxidant defenses and egg characteristics in laying hens. The objectives of this study were to investigate the effects of a specific melon concentrate on oviduct antioxidant defenses and egg characteristics of laying hens.Lohmann Brown hens were assigned to 2 treatment groups (n = 16 in each). One group...

Kim, Y.; Chung, S.; Lee, I.K.m, H.; Lee, K.; Yim, S., 2007: Altered DNA copy number in patients with different seizure disorders: By array-CGH. Epilepsia 48(Suppl. 7): 130

Pritchard, B.; Autschbach, J., 2012: Theoretical investigation of paramagnetic NMR shifts in transition metal acetylacetonato complexes: analysis of signs, magnitudes, and the role of the covalency of ligand-metal bonding. Ligand chemical shifts are calculated and analyzed for three paramagnetic transition metal tris-acetylacetonato (acac) complexes, namely high-spin Fe(III) and Cr(III), and low-spin Ru(III), using scalar relativistic density functional theory (DFT)...

Anonymous, 1977: Norwegian Nurses' Association's extraordinary National Conference 1976: unanimous support for executive board's position. Sykepleien 64(1): 4-5, 12

Lépy, M-Christine.; Brun, P.; Collin, C.; Plagnard, J., 2006: Experimental validation of coincidence summing corrections computed by the ETNA software. The ETNA software has been developed to compute efficiency transfer and coincidence summing corrections. Different experiments are combined to test the validity of this last facility. Point sources with multi-gamma emitters are measured at several...

Zhong Huilan.; X.Z.ipiao.; Gao Peizhi., 1979: Preliminary studies on paragonimiasis in Ich'un, Hokiang and Mutankiang areas of Heilungkiang Province with observations on a new species of Paragonimus westermani ichunensis. Acta Zoologica Sinica, 251: 33-43