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Pubertal testosterone influences threat-related amygdala-orbitofrontal cortex coupling

, : Pubertal testosterone influences threat-related amygdala-orbitofrontal cortex coupling. Social Cognitive and Affective Neuroscience 10(3): 408-415

Growing evidence indicates that normative pubertal maturation is associated with increased threat reactivity, and this developmental shift has been implicated in the increased rates of adolescent affective disorders. However, the neural mechanisms involved in this pubertal increase in threat reactivity remain unknown. Research in adults indicates that testosterone transiently decreases amygdala-orbitofrontal cortex (OFC) coupling. Consequently, we hypothesized that increased pubertal testosterone disrupts amygdala-OFC coupling, which may contribute to developmental increases in threat reactivity in some adolescents. Hypotheses were tested in a longitudinal study by examining the impact of testosterone on functional connectivity. Findings were consistent with hypotheses and advance our understanding of normative pubertal changes in neural systems instantiating affect/motivation. Finally, potential novel insights into the neurodevelopmental pathways that may contribute to adolescent vulnerability to behavioral and emotional problems are discussed.


PMID: 24795438

DOI: 10.1093/scan/nsu062

Other references

Okamoto Y., 1990: Analysis of individual differences in the size numerosity illusion by scalar product model. Stevens and Rubin (1970) investigated the size-weight illusion using magnitude estimation method and Anderson (1970) investigated the same illusion by rating method. But, in general, both methods of magnitude estimation and rating were criticized...

Dr. K.V.Allebrandt PhD., 2013: Sleep duration and metabolic syndrome. Extremes in duration of sleep have been associated with adverse health, specifically with the symptomatology characteristic of the metabolic syndrome. Body homeostasis and circadian rhythm are thought to interact and to influence energy metabolism...

Pascovschi, S., 1975: Citeva cazuri de amplasare curioasa a cuiburilor unor pasari. Studii Commun Muz Stiint Nat Bacau (Biol Anim): 6: 325-330

Higgins, M.D.; van Breemen, O., 1992: The age of the Lac-Saint-Jean anorthosite complex and associated mafic rocks, Grenville Province, Canada. Canadian Journal of Earth Sciences 29(7): 1412-1423

Csornai, M.; Vámosi, B.; Rochlitz, S.; Rutkovszky, E., 1987: Epidemiologic data and risk factors of our cerebrovascular patients. Orvosi Hetilap 128(51): 2683-2689

Grangeiro, T.Barbosa.; Jorge,; Bezerra, W.Melgaço.; Vasconcelos, A.Tereza.Ribeiro.; Simpson, A.John.George., 2004: Transport genes of Chromobacterium violaceum: an overview. The complete genome sequence of the free-living bacterium Chromobacterium violaceum has been determined by a consortium of laboratories in Brazil. Almost 500 open reading frames (ORFs) coding for transport-related membrane proteins were identified...

Jackson, D.B., 2017: Diet quality and bullying among a cross-national sample of youth. Bullying perpetration and victimization have been linked to a number of high-risk health behaviors, including involvement in sedentary activities and sleep deprivation. Even so, the link between diet quality and bullying is generally overlooked. T...

Reed, D.; Pojar, T.; Woodard, T., 1974: Mule deer responses to deer guards. Journal of range management: 27 (2) 111-113

Xu, Y.; Sculimbrene, B.R.; Miller, S.J., 2006: Streamlined synthesis of phosphatidylinositol (PI), PI3P, PI3,5P2, and deoxygenated analogues as potential biological probes. Highly direct total syntheses of phosphatidylinositol (PI), phosphatidylinositol-3-phosphate (PI3P), phosphatidylinositol-3,5-bisphosphate (PI3,5P(2)), and a range of deoxygenated versions are reported. Each synthesis is carried out to deliver the...

V.G.A.ruk; K.C.R.cha; C.P.nhal; D.M.raes-Vasconcelos;; A.S.G.umach, 2007: Complement and specific antibody response in HIV-Negative patients with neurocryptococcosis. Molecular Immunology 44(16): 1