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Public funding of new cancer drugs: Is NICE getting nastier?

, : Public funding of new cancer drugs: Is NICE getting nastier?. European Journal of Cancer 45(7): 1188-1192

Decision-making processes that determine cancer drug availability vary internationally. The National Institute for Health and Clinical Excellence (NICE) assesses clinical and cost-effectiveness, but recent restrictions on the availability of cancer drugs suggest that NICE may be getting tougher. To determine whether NICE is rejecting a higher proportion of cancer drugs and whether the reasons for restricting technologies have changed. NICE decisions on cancer drugs from May 2000 to October 2008 were classified as 'positive', 'restricted' or 'negative', and decisions taken before and after a change in NICE's appraisal methods in August 2006 were compared. NICE's stated reasons for its restrictions were analysed. Fifty-six cancer drugs in 38 appraisals were analysed. The proportion of 'negative' appraisals increased from 4% in period 1 to 27% in period 2. Findings were similar when analysed by drug assessment (11% versus 26%). The higher rejection rate for cancer drugs is partly explained by the new appraisal process, but the principal reason for the observed change is the shift from an absence of evidence on cost-effectiveness to evidence of an absence of value-for-money.


PMID: 19138512

DOI: 10.1016/j.ejca.2008.11.040

Other references

Afonso, O., 1979: Un Proasellus (Crust. Isopoda) nouveau du Portugal. Anais da Faculdade de Ciencias Universidade do Porto. 1978- ; 611-4: 91-104

Marinković, R.; Polzović, A.; Gudović, R.; Marjanović, M.; Curcić, B., 1986: Stereologic analysis of the development of the claustrum between the 14th and 19th week of gestational age. Medicinski Pregled 39(7-8): 313-316

Benson, H.A.E.; Prankerd, R.J., 1997: Optimisation of drug delivery: 3. Sustained/controlled-release oral drug delivery. The present article reviews in detail some mechanisms by which modification of drug release from oral dosage forms can be achieved. Biopharmaceutical and physicochemical characteristics of drugs suitable for modified release are outlined. Design c...

Cheng, C., 1990: Preliminary probe into the cause of the black substance emerging in the course of the processing of sulfur with bean curd. The author has probed into the reason why bean curd assumes a black green colour in the course of processing sulfur, and made an X-ray crystallographic and qualitative analysis of the substance which makes bean curd assume this colour during the p...

Dong, S.; Yuan, Z.; Zhang, L.; Lin, Y.; Lu, C., 2017: Rapid Screening of Oxygen States in Carbon Quantum Dots by Chemiluminescence Probe. The oxygen states (O-states) of carbon quantum dots (CDs) play an important role, with regard to their optical properties and analytical applications. However, the rapid screening of O-states in CDs is still a great challenge, because of the compl...

Boué, A., 1987: Genetics of 21-hydroxylase deficiency. Archives Francaises de Pediatrie 44(2): 75-78

Neiman, H.L.; Phillips, J.F.; Jaques, D.A.; Brown, T.L., 1976: Ultrasound of the parotid gland. Five cases of parotid gland masses were studied by ultrasound. Only retention cysts and true cysts of the parotid gland appear sonolucent at low and high gain settings. Benign and malignant tumor present as solid masses except for the Warthin&apos...

Courteney-Harris, R.G.; Ford, G.R.; Ganiwalla, T.M.; Mangat, K.S., 1992: Closure of tympanic membrane perforation after the removal of Goode-type tympanostomy tubes: the use of silastic sheeting. The reported incidence of persistent tympanic membrane perforation after the extrusion or removal of Goode-type tympanostomy tubes varies from 3 per cent to 47.5 per cent. A prospective randomized study of 152 Goode-type T-tube removals is present...

Rigopoulos, C.; Kyriazis, I.; Kallidonis, P.; Kalogeropoulou, C.; Koumoundourou, D.; Georgiopoulos, I.; Petsas, T.; Karnabatidis, D.; Constantinides, C.; Liatsikos, E., 2013: Assessing the use of haemostatic sealants in tubeless percutaneous renal access and their effect on renal drainage and histology: an experimental porcine study. To evaluate the mid-term effects of haemostatic sealant application during tubeless percutaneous nephrolithotomy (PCNL) on renal drainage and histology in an in vivo porcine study.Bilateral percutaneous access was established in 28 porcine renal u...

Yu, C.L.; Sun, K.H.; Tsai, C.Y.; Hsieh, S.C.; Yu, H.S., 2001: Anti-dsDNA antibody up-regulates interleukin 6, but not cyclo-oxygenase, gene expression in glomerular mesangial cells: A marker of immune-mediated renal damage?. Objective and Design: To determine whether anti-double stranded DNA antibody (anti-dsDNA) can affect the synthesis of eicosanoids and cytokines in rat glomerular mesangial cells (RMC). Materials or Subjects: Glomerular mesangial cells were isolate...