geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester


, : Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester. Ultrasound in Obstetrics & Gynecology 30(3): 275-280

Congenital heart disease is associated with high mortality and morbidity rates, being the most life-threatening defect in the first month of postnatal life and accounting for approximately half of all childhood mortality from birth defects. Despite this, the prenatal detection rate for congenital outflow tract anomalies by ultrasound imaging is relatively low. The aim of this study was to establish a nomogram for the pulmonary artery/aorta (PA/AO) ratio measured in the three-vessel view plane. This ratio was investigated as a simple screening tool for congenital cardiac outflow tract abnormalities. The study was a prospective evaluation of 966 singleton fetuses at 16-24 weeks of gestation and 46 fetuses with congenital cardiac outflow tract abnormalities. The diameters of the pulmonary artery and aorta were measured in the three-vessel view. The PA/AO ratio was calculated and a nomogram was constructed. The mean and 95% CI for the ratio were defined and the PA/AO ratios of cases with outflow tract abnormalities were plotted against the values for normal fetuses. The gestational age of the normal group ranged from 16 to 24 weeks, with a median of 19 weeks. The pulmonary artery diameter measured between 2.1 and 4.93 mm (mean, 3.3 mm) and the aorta measured between 2.1 and 5.2 mm (mean, 2.93 mm). The mean (SD) PA/AO ratio was 1.16 (0.18) (95% CI, 0.87-1.58; range 0.61-1.86; median, 1.14). For fetuses with outflow tract abnormalities, the median gestation was 19 weeks and 37/43 (86%) had a PA/AO ratio outside the 95% CI. The PA/AO ratio derived from measurements in the three-vessel view plane can be used as an initial screening tool for outflow tract anomalies and may have a sensitivity of up to 86%, with a 5% false-positive rate.

US$19.90

PMID: 17721863

DOI: 10.1002/uog.4105


Other references

Kagawa, H.; Horiuchi, Y.; Kasuga, Y.; Kishi, T., 2010: Oocyte hydration in the Japanese eel (Anguilla japonica) during meiosis resumption and ovulation. In this study, to elucidate the mechanisms of oocyte hydration in the Japanese eel (Anguilla japonica), we examined the in vivo and in vitro morphological changes and hydration process occurring during oocyte maturation and ovulation. We also inve...

Cohn, S.A.; Mcguire, J.R., 2000: Using diatom motility as an indicator of environmental stress: Effects of toxic sediment elutriates. We investigated the possibility of using diatom motility as an indicator for screening potentially toxic sediments. Carticula cuspidata (Kutzing) D.G. Mann cells were incubated for up to 4 h in elutriates made from four previously characterized se...

Fabbri, G.; Khiabanian, H.; Holmes, A.B.; Wang, J.; Messina, M.; Mullighan, C.G.; Pasqualucci, L.; Rabadan, R.; Dalla-Favera, R., 2013: Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome. Richter syndrome (RS) derives from the rare transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly of the diffuse large B cell lymphoma (DLBCL) type. The molecular pathogenesis of RS is only partially under...

Anonymous, 1990: Colorado group develops aid for documentation. The Colorado Peer Review Organization (PRO), the Colorado Foundation for Medical Care, has implemented the PROMPTER concept in an effort to assist physicians in charting information essential to PRO review. The examples that follow are adapted fro...

Lehovský, M.; Kraus, J.; Tosnarová, V., 1975: Use of Hoffmann's reflex in the study of spasticity in children. Ceskoslovenska Pediatrie 30(9): 405-406

Yao, Y.; Suraokar, M.; Darnay, B.G.; Hollier, B.G.; Shaiken, T.E.; Asano, T.; Chen, C-Hung.; Chang, B.H-J.; Lu, Y.; Mills, G.B.; Sarbassov, D.; Mani, S.A.; Abbruzzese, J.L.; Reddy, S.A.G., 2013: BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Phosphorylation and activation of Akt1 is a crucial signaling event that promotes adipogenesis. However, neither the complex multistep process that leads to activation of Akt1 through phosphorylation at Thr³⁰⁸ and Ser⁴⁷³ nor the mechanis...

Daget P., 1982: A study on vegetation structure by analysis of intervals in sequence of sampling units. Poisson's stochastic process can be taken as a model for the analysis of a sequence of presences and absences. An initial empty sequence follows a geometrical or Pascal's law. The result can be applied to the analysis of structure and ho...

Poria, Y.; Butler, R.; Airey, D., 2004: The meanings of heritage sites for tourists: the case of Massada. Recent studies concerning spaces where heritage artifacts are presented claim that at the heart of tourists' behaviour lies the perception of the site in relation to their own heritage. This study investigates this supposition by examining th...

Berlemont, M.; Mestdagh, H., 1988: Extensive coxo-femoral resection with preservation of the thumb for prosthesis. An alternative to disarticulation at the hip. To avoid the severe mutilation of a hip disarticulation and to improve limb-fitting, a method of partial limb preservation is proposed. Two cases of septic arthritis of the hip with neurological and atrophic lesions sufficient to justify disarticu...

Boor, P.; Bozek, P.; Blazícek, P.; Syrová, D.; Schinzel, R.; Heidland, A.; Pecovová, A.; Sebeková, K., 2001: Increased levels of circulating advanced glycation end products in a model of acute renal insufficiency in rats. Advanced glycation end products (AGEs) are formed from proteins and peptides by non-enzymatic glycation or glycooxidation. AGEs are formed slowly during aging, and they accumulate in circulation and tissues in diabetes and chronic renal failure. K...