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Quantification of cerebral perfusion using dynamic quantitative susceptibility mapping

, : Quantification of cerebral perfusion using dynamic quantitative susceptibility mapping. Magnetic Resonance in Medicine 73(4): 1540-1548

The purpose of this study is to develop a dynamic quantitative susceptibility mapping (QSM) technique with sufficient temporal resolution to map contrast agent concentration in cerebral perfusion imaging. The dynamic QSM used a multiecho three-dimensional (3D) spoiled gradient echo golden angle interleaved spiral sequence during contrast bolus injection. Four-dimensional (4D) space-time resolved magnetic field reconstruction was performed using the temporal resolution acceleration with constrained evolution reconstruction method. Deconvolution of the gadolinium-induced field was performed at each time point with the morphology enabled dipole inversion method to generate a 4D gadolinium concentration map, from which three-dimensional spatial distributions of cerebral blood volume and cerebral blood flow were computed. Initial in vivo brain imaging demonstrated the feasibility of using dynamic QSM for generating quantitative 4D contrast agent maps and imaging three-dimensional perfusion. The cerebral blood flow obtained with dynamic QSM agreed with that obtained using arterial spin labeling. Dynamic QSM can be used to perform 4D mapping of contrast agent concentration in contrast-enhanced magnetic resonance imaging. The perfusion parameters derived from this 4D contrast agent concentration map were in good agreement with those obtained using arterial spin labeling.


PMID: 24733457

DOI: 10.1002/mrm.25257

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