geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Quantifying the material and structural determinants of bone strength


, : Quantifying the material and structural determinants of bone strength. Best Practice & Research. Clinical Rheumatology 23(6): 741-753

The ability of a bone to resist fracture depends on the amount of bone present, the spatial distribution of the bone mass as cortical and trabecular bone and the intrinsic properties of the bone material. Whereas low areal bone mineral density (aBMD) predicts fractures, its sensitivity and specificity is low, as over 50% of fractures occur in persons without osteoporosis by BMD testing and most women with osteoporosis do not sustain a fracture. New non-invasive imaging techniques, including three-dimensional (3D) assessments of bone density and geometry, microarchitecture and integrated measurements of bone strength such as finite element analysis (FEA), provide estimates of bone strength that can be used to increase the sensitivity and specificity of fracture risk assessment. Initial observations have shown that these techniques provide information that will improve our understanding of the pathophysiology of skeletal fragility and suggest that these techniques are likely to have a role in the clinical management of individuals at risk for fracture.

US$19.90

PMID: 19945686

DOI: 10.1016/j.berh.2009.09.008


Other references

I.V.Kudryashova, 2011: Structural and functional modifications of presynaptic afferents Do they correlate with learning mechanisms?. We review the modern data on the involvement of structural modifications of presynaptic afferents during the acquisition of individual experiences. During the ontogeny or regeneration of nervous tissue, this mechanism is responsible for adjusting...

Tsarev, N.I.; Artarchuk, K.A.; Tsarev, V.N., 1981: Late secondary hemorrhage in subcutaneous injury to the kidney. Voenno-Meditsinskii Zhurnal: 61-62

Mitrevski, B.; Marriott, P.J., 2015: Evaluation of quadrupole-time-of-flight mass spectrometry in comprehensive two-dimensional gas chromatography. Quadrupole time-of-flight mass spectrometry (Q-TOFMS) has been evaluated with respect to its applicability in comprehensive two-dimensional gas chromatography (GC×GC). At a maximum acquisition frequency, while approximately 50 full accurate mass...

McNulty, J.; Nair, J.J.; Bollareddy, E.; Keskar, K.; Thorat, A.; Crankshaw, D.J.; Holloway, A.C.; Khan, G.; Wright, G.D.; Ejim, L., 2010: Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations. An investigation of the constituents in heartwood and resin of Prunus avium is reported. A mini-library of structurally diverse flavanones and flavones was screened for human cytochrome P450 1A1, 3A4 and 19 (aromatase) inhibition, and for antifung...

Moloshnikov, S.V., 2009: Ordezhosteus, a new psammosteid genus Heterostraci, Psammosteiformes from the lower Frasnian Upper Devonian of the Main Devonian Field. A new psammosteid, Oredezhosteus kuleshovi gen. et sp. nov., from the Amata Regional Stage (Lower Frasnian) of the Leningrad Region is described. In addition, Psammosteus livonicus Obruchev from beds of the same age from Latvia is included in the...

Seli, P.; Smallwood, J.; Cheyne, J.Allan.; Smilek, D., 2016: On the relation of mind wandering and ADHD symptomatology. Mind wandering seems to be a prototypical feature of attention-deficit/hyperactivity disorder (ADHD). However, an important emerging distinction of mind-wandering types hinges on whether a given episode of mind wandering reflects a failure of exec...

Ford, R.V.; Borreson, R.E.; Lindley, G.R.; Moyer, J.H., 1957: A comparative study of the effects of four different Rauwolfia preparations administered parenterally. Reserpine, deserpidine, rescinnamine, and serpentine were subjected to bioassay for hypotensive potency in human hypertensive patients. The drugs were given parenterally. Reserpine and rescinnamine were most effective with the least number of side...

Rosa-Neto, P.; Diksic, M.; Okazawa, H.; Leyton, M.; Ghadirian, N.; Mzengeza, S.; Nakai, A.; Debonnel, G.; Blier, P.; Benkelfat, C., 2004: Measurement of brain regional alpha-(11C)methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Context: The serotonin hypothesis of depression invokes a relative or absolute deficit of serotonin neurotransmission. Reduced synthesis of serotonin in the brain pathways mediating the expression of mood (ie, the limbic cortex) is a plausible can...

Bro, R.Smussen, F.; Bundgard, J.P., 1956: Colpocentesis as a diagnostic aid in extrauterine pregnancy. Ugeskrift for Laeger 118(42): 1224-1227

Rana, N.; Tikaram, S.M., 2001: Performance index based evaluation of anticoccidials against field strains of Eimeria tenella in broiler chickens. The efficacy of amprolium, clopidol, nitrofurazone + furazolidone and sodium sulphadimethylpyrimidine against 4 field strains of Eimeria tenella isolated from severe outbreaks of coccidiosis at 4 different broiler farms, at the Hisar and Jind dist...