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Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine


, : Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine. Molecular Imaging and Biology 9(3): 151-157

The appetite suppressants fenfluramine and dexfenfluramine were widely prescribed before being withdrawn from the market in 1997. Both drugs are known to have the potential to damage brain serotonin (5-HT) axons and axon terminals in animals, including nonhuman primates. This study used quantitative positron emission tomography (PET) with [(11)C] McN5652, a serotonin transporter (SERT) ligand to determine whether humans previously exposed to fenfluramines showed reductions in SERT binding parameters. Subjects previously treated with fenfluramines for weight loss (N = 15) and age-matched controls (N = 17) underwent PET studies with [(11)C] McN5652. Global and regional distribution volumes (DVs) of [(11)C] McN5652 were compared in the two subject groups using parametric statistical analyses. Compared to controls, subjects previously exposed to fenfluramines had significant reductions in [(11)C]McN5652 binding in 14 of 15 regions of interest, more than four years after drug discontinuation. These results are the first to provide direct evidence for fenfluramine-induced 5-HT neurotoxicity in humans.

US$19.90

PMID: 17473958

DOI: 10.1007/s11307-007-0082-7


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Fenton, E.Wyllie, 1935: The transition from woodland and moorland to grassland in the Spey Valley and elsewhere. Pinus silvestris is the dominant tree. Oaks are infrequent. Juniper is almost constant in the open woods, with or without birch. Birch has replaced pine in some places. Bracken seems to follow birch in its spread. Moors are extensive. Some are on...

Oda K.; Kamada M.; Murao S., 1972: Some physicochemical properties and substrate specificity of acid protease of rhodotorula glutinis k 24. Agricultural & Biological Chemistry 36(7): 1103-1108

Stewart, R.J.; Perry, K.; Bowie, R.D.; O'Dea, D.J., 1994: Peritoneal cytology for suspected acute appendicitis: an economic evaluation. Suspected acute appendicitis is a common reason for surgery. Unfortunately, diagnosis is not always simple and, in recent years, considerable attention has been devoted to developing better diagnostic techniques. Peritoneal cytology is one such te...

Collie, J.S.; Walters, C.J., 1987: Alternative recruitment models of Adams River sockeye salmon, Oncorhynchus nerka. Despite evidence of depensatory interactions among year-classes of Adams River sockeye salmon (Oncorhynchus nerka ), the best management policy is one of equal escapement for all year-classes. The authors fit alternative models (Ricker model and L...

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