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RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment


, : RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment. Journal of Neuroscience 34(26): 8749-8760

Ischemia is known to increase the deleterious effect of β-amyloid (Aβ), contributing to early cognitive impairment in Alzheimer's disease. Here, we investigated whether transient ischemia may function as a trigger for Aβ-dependent synaptic impairment in the entorhinal cortex (EC), acting through specific cellular signaling. We found that synaptic depression induced by oxygen glucose deprivation (OGD) was enhanced in EC slices either in presence of synthetic oligomeric Aβ or in slices from mutant human amyloid precursor protein transgenic mice (mhAPP J20). OGD-induced synaptic depression was ameliorated by functional suppression of RAGE. In particular, overexpression of the dominant-negative form of RAGE targeted to microglia (DNMSR) protects against OGD-induced synaptic impairment in an amyloid-enriched environment, reducing the activation of stress-related kinases (p38MAPK and JNK) and the release of IL-1β. Our results demonstrate a prominent role for the RAGE-dependent neuroinflammatory pathway in the synaptic failure induced by Aβ and triggered by transient ischemia.

US$19.90

PMID: 24966375

DOI: 10.1523/JNEUROSCI.0141-14.2014


Other references

Ebel, H.C.; Werboff, J., 1967: Transposition in dogs: successive reversals of the intermediate size problem. The response of secondary endings of de-efferented muscle spindles in the soleus muscle of the anaesthetized cat was recorded during stretching of the muscle at velocities of 5-30 mm/sec. Stimulation of single fusimotor fibres, most and probably a...

Rao J.S.; Hantai D.; Festoff B.W., 1987: Thrombospondin quantitation and distribution on muscle basement membranes in neuromuscular diseases. Society for Neuroscience Abstracts 13(1): 496

Moskvicheva I.V.; Dudkina M.I.; Zuev A.S.; Cherkasov A.N.; Shapiro N.I., 1972: The relationship of the immunological properties of salmonella typhi antigenic preparation fractions and their molecular weight. Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 49(10): 82-86

Lunde, L-Kristian.; Koch, M.; Hanvold, T.N.; Wærsted, M.; Veiersted, K.B., 2016: Low back pain and physical activity--A 6.5 year follow-up among young adults in their transition from school to working life. The association between leisure time physical activity and low back pain in young adults is unclear and is in the need of prospectively obtained evidence. This study examined the course of low back pain and the association between low back pain an...

Lai, C-Hsien.; Wu, S-Rong.; Pang, J-Chieh.; Ramireddy, L.; Chiang, Y-Cheng.; Lin, C-Ku.; Tsen, H-Yang., 2017: Designing primers and evaluation of the efficiency of propidium monoazide - Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius. The purpose of this study is to evaluate the efficiency of using propidium monoazide (PMA) real-time quantitative polymerase chain reaction (qPCR) to count the viable cells of Lactobacillus gasseri and Lactobacillus salivarius in probiotic product...

Bell R.G.; Lynch N.R.; Turner K.J., 1974: Immuno globulins of the marsupial setonix brachyurus quokka characterization of 3 major serum classes immuno globulin g 2 immuno globulin g 1 and immuno globulin m. Immunology 27(6): 1103-1115

David, T.E.; Feindel, C.M., 1992: An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta. A number of patients who require an operation for complications of annuloaortic ectasia, such as aortic incompetence or aneurysm of the aortic root (or both), have normal aortic valve leaflets. We have treated these patients by excising the aneury...

Thomas, H.M.I.i; Fried, E.D.; Novitch, R.S.; Carson, R.C., 1993: Inhibition of pulmonary vasoconstriction by diphenyleneiodonium Lack of a role for K+ channel opening and for glutathione reductase inhibition. Circulation 88(4 PART 2): I143

Lenz A.C.; Melchin M.J., 1991: Wenlock silurian graptolites cape phillips formation canadian arctic islands. Twenty six of the more important species of monograptids (s.l.), retiolitids and Cyrtograptus (from a total fauna of 52 species) are described form Wenlock strata of the Cape Phillips Formation, Canadian Arctic Archipelago. Of this fauna, eight ne...

Fiestas Ros de Ursinos, J.A.; Graciani Constante, E.; Maestro Duran, R.; Vazquez Roncero, A., 1972: Study of a natural attractant for Dacus oleae. Field and laboratory studies in Spain in 1967-69 indicated that, during certain periods of their ripening, olives contain substances that strongly attract adults of Dacus oleae (Gmel.) but that these substances are not present continuously through...