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Radiofrequency fields, transthyretin, and Alzheimer's disease

, : Radiofrequency fields, transthyretin, and Alzheimer's disease. Journal of Alzheimer's Disease 20(2): 599-606

Radiofrequency field (RF) exposure provided cognitive benefits in an animal study. In Alzheimer's disease (AD) mice, exposure reduced brain amyloid-beta (Abeta) deposition through decreased aggregation of Abeta and increase in soluble Abeta levels. Based on our studies on humans on RF from wireless phones, we propose that transthyretin (TTR) might explain the findings. In a cross-sectional study on 313 subjects, we used serum TTR as a marker of cerebrospinal fluid TTR. We found a statistically significantly positive beta coefficient for TTR for time since first use of mobile phones and desktop cordless phones combined (P=0.03). The electromagnetic field parameters were similar for the phone types. In a provocation study on 41 persons exposed for 30 min to an 890-MHz GSM signal with specific absorption rate of 1.0 Watt/kg to the temporal area of the brain, we found statistically significantly increased serum TTR 60 min after exposure. In our cross-sectional study, use of oral snuff also yielded statistically significantly increased serum TTR concentrations and nicotine has been associated with decreased risk for AD and to upregulate the TTR gene in choroid plexus but not in the liver, another source of serum TTR. TTR sequesters Abeta, thereby preventing the formation of Abeta plaques in the brain. Studies have shown that patients with AD have lowered TTR concentrations in the cerebrospinal fluid and have attributed the onset of AD to insufficient sequestering of Abeta by TTR. We propose that TTR might be involved in the findings of RF exposure benefit in AD mice.


PMID: 20164553

DOI: 10.3233/JAD-2010-1395

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Verma, M.B.; Sharma, J.C., 1972: A note on the relative toxicity of certain insecticides to the adult grasshopper, Chloebora crassa Walker (Orthoptera: Acridiidae). Chloebora crassa (Wlk.) is a voracious pest of pasture grasses and occurs extensively in the Indian State of Rajasthan. The toxicity of several insecticides to adults of this grasshopper was tested by a topical method that is described. Probit ana...

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Wood Bernard J., 1994: Storage and recycling of water and carbon dioxide in the Earth. LPI Contribution Pages 48-49

Liu, B.; Tang, C.; Chen, J.; Yan, Z.; Zhu, M.; Sui, Y.; Tang, H., 2017: The Coupling Effects of Surface Plasmon Polaritons and Magnetic Dipole Resonances in Metamaterials. We numerically investigate the coupling effects of surface plasmon polaritons (SPPs) and magnetic dipole (MD) resonances in metamaterials, which are composed of an Ag nanodisk array and a SiO<sub>2</sub> spacer on an Ag substrate. The...

Foster G.R.; Weesies G.A.; Renard K.G.; Yoder D.C.; McCool D.K.; Porter J.P., 1997: Support practice factor (P). Agriculture Handbook United States, Department of Agriculture

Gortler, I., 1991: Antigen and allergen content of hypoallergenic foods for infants with cow milk allergy. This thesis reports a study in which hypoallergenic hydrolysate foods based on soya/collagen, whey protein and casein were tested by ELISA and other immunological methods for antigens and allergens in order to assess their suitability for infants...

Flood, J.F.; Morley, J.E., 1994: Age-related changes in the pharmacological improvement of retention in SAMP8 mice. Takeda, T [Editor] International Congress Series; The SAM model of senescence 89-94

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