+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Raloxifene and body composition and muscle strength in postmenopausal women: a randomized, double-blind, placebo-controlled trial

, : Raloxifene and body composition and muscle strength in postmenopausal women: a randomized, double-blind, placebo-controlled trial. European Journal of Endocrinology 162(2): 371-376

To compare the effects of raloxifene and placebo on body composition and muscle strength. Randomized, double-blind, placebo-controlled trial involving 198 healthy women aged 70 years or older conducted between July 2003 and January 2008 at the University Medical Centre, Utrecht, The Netherlands. Participants were randomly assigned to receive raloxifene 60 mg or placebo daily for 12 months. Measurements were taken at baseline, 3, 6, and 12 months, and change from baseline was calculated. Main outcome measures were body composition (bioelectrical impedance analysis), muscle strength, and muscle power (maximum voluntary isometric knee extension strength, explosive leg extensor power, and handgrip strength). At 12 months, the body composition of women taking raloxifene was significantly different from that of women taking placebo: fat-free mass (FFM) had increased by a mean of 0.83 (2.4) kg in the raloxifene group versus 0.03 (1.5) kg in the placebo group (P=0.05), and total body water had increased by a mean of 0.6 (1.8) litres in the raloxifene group versus a decrease of 0.06 (1.1) litres in the placebo group (P=0.02). Muscle strength and power were not significantly different. Raloxifene significantly changed body composition (increased FFM; increased water content) compared with placebo in postmenopausal women.


PMID: 19884264

DOI: 10.1530/EJE-09-0619

Other references

Lindsay, R.; Chaplin, R., 1970: Preliminary investigations on the storage of dried grass and lucerne wafers. A preliminary investigation into the storage properties of two types of dried grass wafer and four types of dried lucerne wafer was carried out during the period January to June 1968. The wafers were stored for 3 months under ambient conditions in...

Eising, E.G.; John-Mikolajewski, V.; Haritaworn, M.; Bockisch, A., 2000: Correlation of radionuclide ventriculography with roentgenological findings in chemotherapy patients. Radionuclide ventriculography (RNV) is a common method to evaluate cardiotoxic effects of drugs applied during chemotherapeutic treatment, whereas thoracic radiographs are used to detect morphologic alterations. Aim of this study was to identify r...

Iyer, S.N.; Chappell, M.C.; Yamada, K.; Ferrario, C.M., 1998: Angiotensin- regulates blood pressure of spontaneously hypertensive rats maintained on a low-salt diet. Hypertension (Dallas) 32(3): 598, Sept

Little, E.G., 1919: Case of Multiple Neuromata of the Skin. Proceedings of the Royal Society of Medicine 12(Dermatol Sect): 35-35

Phua, S.H.; Wood, N.J., 1993: The myogenic factor 5 (MYF5) locus in sheep carries a rare EcoRI RFLP. 24 unrelated sheep were screened using a 1.26-kb human MYF5 cDNA insert as a probe; 2 allelic fragments were observed. The frequency of the alleles in 32 unrelated sheep of 5 breeds was 0.95 and 0.05. Autosomal codominant segregation of the allele...

Sanders, D.C.; Hoyt, G.D.; Gilsanz, J.C.; Davis, J.M.; Garrett, J.T.; Decoteau, D.R.; Dufault, R.J.; Batal, K.D., 1996: Cover crops and N rates influence sweetpotato production. Hortscience 31(4): 611

Kaminski, S.L.; Grazul-Bilska, A.T.; Harris, E.K.; Berg, E.P.; Vonnahme, K.A., 2015: Impact of maternal physical activity during gestation on porcine fetal, neonatal, and adolescent ovarian development. To determine how exercise from mid to late (days 40-104) gestation impacts offspring body, uterine and ovarian weight, and ovarian cell proliferation at three different developmental stages, Yorkshire gilts were either exercised by walking (EX) or...

Baerlocher, M.O.; Stewart, B.; Asch, M.R.; Raikhlin, A.; Hayeems, E.; Collingwood, P.; Kachura, J.R., 2008: Performance of carotid stenting, vertebroplasty, and EVAR: how many are we doing and why are we not doing more? A survey by the Canadian Interventional Radiology Association. To determine the percentage of interventional radiologists who currently perform 3 interventional procedures: carotid stenting, vertebroplasty, and endovascular aneurysm repair (EVAR) in Canada, and impediments to their future performance by other...

Silvestri, U., 1956: Observations on positive & negative chromatin cells in the human skin in old age. Archivio Italiano di Dermatologia, Sifilografia, E Venereologia 28(5): 341-357

Hernández Montero, E.; Fraile Rodrigo, J.J.; D.M.guel García, F.; Sampériz, L.M.; Eiras Ajuria, J.; Ortiz García, A., 2003: The role of video-nystagmography in the diagnosis of acoustic neuroma. Schwannoma of the vestibular nerve represents 75% of all expansive processes affecting the pontocerebellosum angle. Hearing loss is the most frequent symptom at diagnosis (86%) with or without tinnitus, in the intracanalicular tumors. Vestibular s...