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Rapid eye movement sleep behavior disorder


, : Rapid eye movement sleep behavior disorder. Current Opinion in Neurobiology 23(5): 793-798

Rapid eye movement (REM) sleep behavior disorder (RBD) is a failure of the circuitry regulating motor atonia during REM sleep. In REM sleep, neurons of the sublaterodorsal tegmental nucleus (SLD) project to interneurons in the ventromedial medulla (VMM) and spinal cord that in turn inhibit spinal motoneurons. In RBD, degeneration of this circuitry disinhibits phasic motor commands originating from motor generators. The resulting behavior ranges from simple twitches or jerks to complex behavior. Simple behaviors in RBD may originate from cortical, brainstem and spinal cord motor generators, while complex behavior may originate from cortical motor generators, possibly related to dream content in REM sleep. While RBD can occur idiopathically, it is usually comorbid with or a precursor to a synucleinopathy such as Parkinson's disease (PD). RBD can precede the onset of PD by decades, suggesting an underlying pathology that can progressively afflict REM atonia and midbrain dopaminergic centers. The relative recovery of motor function during REM sleep in some of the cases of PD with RBD emphasizes the complexity of motor pathway control during wakefulness and REM sleep.

US$19.90

PMID: 23518139

DOI: 10.1016/j.conb.2013.02.019


Other references

Erath, H.G.; Graham, T.P.; Hammon, J.W.; Smith, C.W., 1980: Hypoplasia of the systemic ventricle in congenitally corrected transposition of the great arteries: preoperative documentation and possible implications of operation. This article describes the determination of small systemic ventricular volume by quantitative cineangiocardiography in two patients with congenitally corrected transposition of great arteries, Ebstein's malformation of the systemic atrioventr...

Gross, P.A.; Brown, R.A., 1967: Contrasting job satisfaction elements shown for R.N.'s and L.P.N.'s. Hospitals 41(4): 73-92

Ivancheva-Gabrovska, Todora, 1960: Resistance of some Tobacco varieties to 'black-shank' (P.p. var. nicotianae). At Inst. Plant Prot., Sofia, 53 Bulgarian vars. and prospective new lines all proved moderately to highly susceptible to P.p. var. nicotianae . Of 14 foreign vars. assayed, Dixie Bright 101 (immune), Oxford 3, and Huang Mian Ju 79 are recommended...

Thorpe, E.; Brisbourne, R., 1982: Forestry development project Sarawak. Forest industry development. Progress and constraints in the Sarawak logging and processing industries from 1975 to 1979 are discussed with reference to the work of the Sarawak Timber Industry Development Corporation (founded in 1973); recommendations are made for future deve...

Wei, M-Hsiu., 2016: Patterns of Reasons for Taiwanese Adults' Health Information-Seeking Efforts: A Latent Class Analysis Approach. The aims of this study were to use latent class analysis (LCA) to identify subgroups of adults in Taiwan based on their reasons for seeking health information and to explore predictors of subgroup membership. A questionnaire survey of 752 adults f...

Simić, S.; Slankamenac, P.; Cvijanović, M.; Ilin, M.; Kopitović, A., 2006: The impact of headache severity on quality of life of patients with migraine. Migraine is a chronic disease characterized by episodic headache attacks, most often on one side of the head with pulsating, moderate to severe pain. We conducted an assessment of headache severity by using the MIGSEV questionnaire, and the qualit...

Kurihara-Bergstrom, T.; Woodworth, M.; Feisullin, S.; Beall, P., 1986: Characterization of the Yucatan miniature pig skin and small intestine for pharmaceutical applications. Yucatan miniature pig skin and gastrointestinal tract have been characterized as potential models for human organ systems in in vitro and in vivo pharmaceutical experiments. Histology of pig skin and the flux of one classical drug, caffeine, are d...

Furbank, R.T.; Rebeille, F., 1986: Dark respiration in the marine macroalga Chondrus crispus (Rhodophyceae). Dark respiration in the red macroalga Chondrus crispus was studied under a variety of conditions. The components of respiration were examined using selective inhibitors in order to characterize pathways of respiration and examine regulation of res...

King J.B., 1967: Prophylaxis in hemophilic arthropathy letter human hemorrhage hepatitis blood clotting heredity. British Medical Journal 5569: 864

Brody, Al, 2007: Importing good packaging. Food technology 61(2): 72-74