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Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging

, : Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging. Chemical Communications 50(23): 3044-3047

Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.


PMID: 24510148

DOI: 10.1039/c3cc49790a

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