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Reactive species: a cell damaging rout assisting to chemical carcinogens

, : Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Letters 266(1): 73-83

Reactive oxygen and nitrogen species (ROS and RNS) are known to contribute as pathogenic factors to the development of chronic progressive diseases at various stages. The present review discusses the role of oxidative stress in chemically induced cancer development and progression. Reactive species are capable of inducing DNA damage that eventually may contribute to cell transformation and tumor initiation. ROS and RNS are also associated with tumor promotion and progression. Both endogenous processes and redox-cycling of xenobiotic compounds have been shown to result in oxidative DNA damage. In addition, several exocyclic DNA adducts represent secondary DNA damage caused by products of lipid peroxidation in the course of oxidative cellular stress. Due to their intrinsic ability to catalyze redox reactions, transition metals, and quinones from various classes of xenobiotics or endogenous compounds are important mediators of oxidative stress and thus likely of being involved in DNA damage, lipid peroxidation, cell transformation, and tumor development.


PMID: 18367325

DOI: 10.1016/j.canlet.2008.02.035

Other references

Kennedy, D.; Calabrese, R.L.; Wine, J.J., 1974: Presynaptic inhibition: primary afferent depolarization in crayfish neurons. Inhibition of transmission between tactile sensory neurons and interneurons in the crayfish was investigated by intracellular recording int the presynaptic processes. Inhibition is correlated with a depolarization of the presynaptic process, as in...

Mowbray, J.; Hardy, D.L.uise, 1996: Direct thyroid hormone signalling via ADP-ribosylation controls mitochondrial nucleotide transport and membrane leakiness by changing the conformation of the adenine nucleotide transporter. Addition of triiodothyronine at 10 pM in vitro to hypothyroid rat liver mitochondria doubles the rate of the adenine nucleotide transporter at low ADP concentrations. Nicotinamide abolishes this effect in parallel with its inhibition of the ADP-ri...

Smith, E.P., 1977: A Weberian management model. Hospital Progress 58(3): 64-68

Murray, A.K.; Grantz, D.A., 2004: Carbohydrate composition of cotton aphid honeydew. Honeydew from cotton aphids (Aphis gossypii) has been collected from aphids feeding on Pima S-6 plants between the ages of 4 and 7 weeks. The sugars identified in the honeydew are the same as those identified from honeydew of aphids feeding on old...

Gascon Barre M.; Elbaz H.; Therrien Ferland D., 1985: Sequestration and microsomal carbon 25 hydroxylation of tritium labeled vitamin d 3 by the rat liver. A study of the vitamin D3 (D3) 25-hydroxylase was undertaken in an in vivo-in vitro model. {3H}-D3 (0.7, 1.0, 10 or 100 nmol/100 g of body wt) was injected into the portal vein and the liver was excised 18 s later. The liver homogenate was then su...

Baldwin, W.; McCardle, P., 1996: Peer review at NIH in the 21st Century. Faseb Journal 10(14): 1563-1568

Johansson, S.; Montgomery, S.M.; Ekbom, A.; Olausson, P.Otterblad.; Granath, F.; Norman, M.; Cnattingius, S., 2004: Preterm delivery, level of care, and infant death in sweden: a population-based study. To elucidate the role of level of care in combination with other perinatal risk factors for infant death in very preterm deliveries. Population-based cohort study. Sweden, 1992-1998. Singleton infants (2285) born at 24 to 31 completed weeks of ges...

Adams, R., 1958: Prevention of infections in hospitals. American Journal of Nursing 58(3): 344-348

Monchal, T.; Levadoux, M.; Pellet, N.; Nguyen, M.K.; Ottomani, S.; Gaillard, C.; Hornez, E.; Michaut, C., 2007: White tumor of the wrist: a rare site of tuberculosis involvement. Medecine Tropicale 67(2): 134-134

Berthoux, F.; Dechavanne, M.; Viala, J.J.; Traeger, J., 1971: Rapid preparation of human fibrinogen labelled with iodine 125. Pathologie-Biologie 19(7): 439-443