+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Reciprocal cross-talk between Prostaglandin E2 and bone in prostate cancer: a current review

, : Reciprocal cross-talk between Prostaglandin E2 and bone in prostate cancer: a current review. Central European Journal of Urology 64(4): 201-204

In this review we analyzed the role of PGE2 as a possible regulator of bone metabolism and bone metastases in prostate cancer. Published studies were identified by searching computerized bibliographic systems from January 1(st), 2000 to July 1(st), 2011. PGE2 represents a key factor in the modulation of bone metabolism and bone metastatic disease in prostate cancer interacting with bone regulatory signals including the RANK/RANKL/OPG system and Wnt pathways. A high concentration of PGE2 exerts a prevalent stimulatory effect on osteoclastogenesis via OPG/RANK/RANKL axis activation and a inhibitory effect on osteoblastogenesis trough inhibition of Wnt pathway. An inversely low level of PGE2 exerts a stimulatory effect on osteoblastogenesis via activation of the Wnt pathway. Our finding suggests that PGE2 acts as a regulator in maintaining normal bone mass and indicate a mechanism whereby chemical manipulation of PGE2 levels or signaling may be therapeutically beneficial for prostate cancer treatment.


PMID: 24578893

DOI: 10.5173/ceju.2011.04.art2

Other references

Noguchi, Y.; Sakai, R.; Kimura, T., 2003: Metabolomics and its potential for assessment of adequacy and safety of amino acid intake. In this short paper, we suggest some concepts and methods that may be useful in considering a metabolomic approach to the study of amino acid adequacy and safety. We suggest that the analysis of a metabolomic subset, such as amino acids, may yield...

Saito, H.; Nakayama, D.; Matsuyama, H., 2010: Relationship between the initiation of a shallow landslide and rainfall intensity-duration thresholds in Japan. The empirical rainfall intensity and duration (I-D) threshold for the initiation of shallow landslide is newly defined for Japan where heavy rainfalls frequently occur during the East Asian summer monsoon season. The rainfall causes sediment-relat...

Heaney, V.; Monaghan, P., 1995: A within-clutch trade-off between egg production and rearing in birds. Here we compare the chick-rearing capacity of common terns Sterna hirundo that were given an additional chick at hatching (incurring rearing costs but no production costs), an additional egg at the start of incubation (incurring incubation and rea...

Qing, L.; Song, Y.; Dery, H., 2011: Proximity effects of a symmetry-breaking interface on spins of photoexcited electrons. We study reflection of optically spin-oriented hot electrons as a means to probe the semiconductor crystal symmetry and its intimate relation with the spin-orbit coupling. The symmetry breaking by reflection manifests itself by tipping the net-spi...

Stanislawski L.; Simpson W.A.; Hasty D.L.; Sharon N.; Ofek I., 1985: The role of fibronectin in the attachment of streptococcus pyogenes and escherichia coli to human cells. Abstracts of the Annual Meeting of the American Society for Microbiology 85: 24

Milovan, E.; Granciu, I., 1977: Genetic variation of beta -lactoglobulins in the Friesian and the Romanian Brown breeds. Milk samples were obtained from a Romanian Brown (RB) herd and from 3 Friesian herds, comprising 551, 89, 801 and 525 cows. For the 4 herds resp., gene frequencies were as follows: beta -LgA, 0.525, 0.561, 0.669, 0.488; beta -LgB, 0.445, 0.438, 0....

Jones, E.S.; Dupal, M.P.; Kolliker, R.; Drayton, M.C.; Forster, J.W., 2001: Development and characterisation of simple sequence repeat markers for perennial ryegrass. Enrichment methods were optimised in order to isolate large numbers of simple sequence repeat (SSR) markers for perennial ryegrass (Lolium perenne L.), with the aim of developing a comprehensive set of loci for trait mapping and cultivar identific...

Egdahl, R.H., 1973: Ambulatory health-care delivery and the surgeon. Surgery 73(4): 637-638

Lessman, C.A.; Nathani, R.; Uddin, R.; Walker, J.; Liu, J., 2006: Computer-aided meiotic maturation assay (CAMMA) of zebrafish (danio rerio) oocytes in vitro. We have developed a new technique called Computer-Aided Meiotic Maturation Assay (CAMMA) for imaging large arrays of zebrafish oocytes and automatically collecting image files at regular intervals during meiotic maturation. This novel method uses...

Peters, W.W.ebecke, C., 1983: Forest sustention as the principle of forestry. Forstarchiv 54(5): 172-178