geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Reduced dose and duration of peginterferon alfa-2b and weight-based ribavirin in patients with genotype 2 and 3 chronic hepatitis C


, : Reduced dose and duration of peginterferon alfa-2b and weight-based ribavirin in patients with genotype 2 and 3 chronic hepatitis C. Journal of Hepatology 55(3): 554-563

There is increasing interest in identifying patients with chronic hepatitis C genotype 2 or 3 infection in whom it is possible to lower the burden of therapy while retaining high levels of efficacy. Treatment-naive patients with chronic hepatitis C genotype 2/3 infection were randomized to receive peginterferon alfa-2b (1.5μg/kg/wk) for 24weeks (group A); peginterferon alfa-2b (1.0μg/kg/wk) for 24weeks (group B); or peginterferon alfa-2b (1.5μg/kg/wk) for 16weeks (group C), each in combination with weight-based ribavirin (800-1200mg/d). The study population comprised two cohorts: the Hep-Net cohort enrolled in Germany and an International cohort enrolled at study sites throughout Europe and Asia. The primary end point was sustained virological response (SVR). The study included 682 patients; 80.2% had genotype 3 infection. In the intent-to-treat population, SVR rates were 66.5%, 64.3%, and 56.6% in groups A, B, and C, and were similar in Asian and white patients. Treatment differences (A vs. B and A vs. C) failed to reach the predefined margin for noninferiority of -10%; and thus groups B and C failed to show noninferiority relative to group A. Among patients with undetectable HCV RNA at week 4, SVR rates were 75.3%, 75.9%, and 72.4%, respectively. Relapse rates were 17.8%, 16.3%, and 29.3%, respectively. Treatment-emergent serious adverse events were highest in group A and lowest in group C, and adverse events leading to discontinuation were similar across treatment arms. For patients with chronic hepatitis C genotype 2/3 infection, 24weeks of peginterferon alfa-2b (1.5μg/kg/wk) plus weight-based ribavirin remains a standard-of-care therapy; however, treatment for 16weeks may be considered for patients with undetectable HCV RNA at week 4 of the treatment.

US$19.90

PMID: 21237227

DOI: 10.1016/j.jhep.2010.12.024


Other references

Lukacova, N.; Marsala, M.; Halat, G.; Marsala, J., 1997: Neuroprotective effect of graded postischemic reoxygenation in spinal cord ischemia in the rabbit. Early ischemia/reperfusion-induced changes of four phospholipid compounds bound to the inner cell membrane leaflet, i.e., phosphatidic acid, inositol phospholipids, serine phospholipids, and ethanolamine plasmalogens, were studied in a model of sp...

Moon, J., 1988: I think I've read something about that!. Cleft Palate Journal 25(1): 79-79

Timchenko, N.F., 2006: Yersinia pseudotuberculosis toxins. The review of publications about protein toxins Y. pseudotuberculosis are presented. It includes the main data obtained by domestic and foreign investigators as well as the results of our own elaboration in the study of Y. pseudotuberculosis prote...

Bowers G.B.; Abuelo D., 1986: Genetic counseling for nuchal cysts diagnosed prenatally. American Journal of Human Genetics 39(3 SUPPL): A174

Bowles, N.E.; Jimenez, S.; Vatta, M.; Chrisco, M.; Szmuszkovicz, J.; Capetanaki, Y.; Perles, Z.; Towbin, J.A., 2002: Familial Restrictive Cardiomyopathy caused by a missense mutation in the desmin gene. Pediatric Research 51(4 Part 2): 224A, April

Lewis, W.G.; Smillie, L.B., 1980: The amino acid sequence of rabbit cardiac tropomyosin. The amino acid sequence of rabbit cardiac tropomyosin has been investigated by the isolation of peptides derives from cyanogen bromide and proteolytic degradations. Based on identical amino acid compositions, electrophoretic mobilities, and in som...

Scheibe, O., 1959: Energy provision in the postoperative period. Langenbecks Archiv für Klinische Chirurgie ... Vereinigt Mit Deutsche Zeitschrift für Chirurgie 292: 124-128

Latt, S.A.; Stetten, G.; Juergens, L.A.; Willard, H.F.; Scher, C.D., 1975: Recent developments in the detection of deoxyribonucleic acid synthesis by 33258 Hoechst fluorescence. A number of applications of the detection of deoxyribonucleic acid synthesis by fluorescence microscopy are illustrated. These include (a) the analysis of sister chromatid exchanges and sister chromatid segregation at mitosis, (b) the location of...

Achim, Aélie.M.; Ouellet, R.; Roy, M-André.; Jackson, P.L., 2012: Mentalizing in first-episode psychosis. Mentalizing deficits have often been observed in people with schizophrenia and a few recent studies suggest that such deficits are also present in patients with first episode psychosis (FEP). It is not clear, however, whether these mentalizing def...

Szostak Ludwik; Dubiel Stanislaw; Chrzaszcz Waclaw; Rzyczniak Miroslaw, 1980: Determination of reservoir parameters in horizons of fractured-and-porous rocks. Technika Poszukiwan Geologicznych 19(6-90): 6-13