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Regulation of epithelial-mesenchymal transition in palatal fusion

, : Regulation of epithelial-mesenchymal transition in palatal fusion. Experimental Biology and Medicine 234(5): 483-491

During palatal fusion, the midline epithelial seam between the palatal shelves degrades to achieve mesenchymal confluence. Morphological and molecular evidence support the theory that the epithelial-mesenchymal transition is one mechanism that regulates palatal fusion. It appears that transforming growth factor (TGF)-beta signaling plays a role in palatal EMT. TGFbeta3 is the main inducer in palatal fusion and activates both Smad-dependent and -independent signaling pathways, including the key EMT transcription factors, Lef1, Twist, and Snail1, in the MEE prior to the palatal EMT program. The roles and interactions among these transcription factors will be discussed.


PMID: 19234053

DOI: 10.3181/0812-MR-365

Other references

Swemmer, A., 2007: Residue analysis: analytical requirements and future trends. Pluimvee Poultry Bulletin (October): 562-564

Ebashi, S.; Ebashi, F.; Yamauchi, I., 1962: Role of relaxing factor in excitation-contraction couplin. Folia Pharmacol Japon 58(4): 27

Mullan, F.; Headrick, L., 1998: Linda Headrick, MD: seeking a common language in primary care. JAMA 280(7): 655-658

Mohs, R.C.; Shiovitz, T.M.; Tariot, P.N.; Porsteinsson, A.P.; Baker, K.D.; Feldman, P.D., 2009: Atomoxetine augmentation of cholinesterase inhibitor therapy in patients with Alzheimer disease: 6-month, randomized, double-blind, placebo-controlled, parallel-trial study. To examine the efficacy and tolerability of atomoxetine (ATX) in improving cognitive performance of patients with Alzheimer dementia. A randomized, double-blind, placebo (PLA)-controlled, parallel-groups study, starting with a 5-33-day screening a...

Ylä-Herttuala, S.; Baker, A.H., 2017: Cardiovascular Gene Therapy: Past, Present, and Future. Cardiovascular diseases remain a large global health problem. Although several conventional small-molecule treatments are available for common cardiovascular problems, gene therapy is a potential treatment option for acquired and inherited cardiov...

Gribbin H.R.; D.M.ria G.; Wang Y.T.; Pride N.B., 1982: Electrical activity of the diaphragm during maximum inspiratory efforts and carbon di oxide re breathing. Clinical Science (London) 63(3): 41P

Auclair J.; Georges M.; Grapton X.; Gryp L.; D'hooghe M.; Meiser R.G.; Noto R.; Schmidtmayer B., 1989: A double blind controlled multicenter study of percutaneous niflumic acid gel and placebo in the treatment of achilles heel tendinitis. The clinical efficacy and safety of percutaneous niflumic acid gel were investigated in adult patients with Achilles heel tendinitis. A double-blind three-week study was conducted in 243 patients in eight centers in France, Belgium, and the Federa...

Pedersen, C.A.; Caldwell, J.D.; Drago, F.; Noonan, L.R.; Peterson, G.; Hood, L.E.; Prange, A.J., 1988: Grooming behavioral effects of oxytocin. Pharmacology, ontogeny, and comparisons with other nonapeptides. Annals of the New York Academy of Sciences 525: 245-256

Ferrans V.J., 1988: Effects of toxic substances on the heart. Sperelakis, N (Ed ) Developments in Cardiovascular Medicine, 90 Physiology And Pathophysiology Of The Heart, Second Edition Xxiii+1009p Kluwer Academic Publishers: Dordrecht, Netherlands; Boston, Massachusetts, Usa Illus 691-708

Beatson, S.A.; Bartley, P.B., 2017: Diving Deep Into Hospital-Acquired Legionella pneumophila With Whole-Genome Sequencing. Clinical Infectious Diseases 64(9): 1260-1262