geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Regulation of the colonic vitamin D system for prevention of tumor progression: an update


, : Regulation of the colonic vitamin D system for prevention of tumor progression: an update. Future Oncology 5(4): 493-507

A compromised vitamin D status and nutritional calcium deficit are linked with sporadic colorectal cancer incidence. 25(OH)D(3) serum concentration is a major determinant of 1,25-dihydroxyvitamin D3 (1,25[OH](2)D(3)) synthesis in colonic mucosa, which expresses the vitamin D receptor and both the synthesizing (CYP27B1) and catabolic (CYP24A1) hydroxylases. Receptor-bound, 1,25(OH)(2)D(3) regulates proliferation, differentiation and apoptosis in an autocrine/paracrine manner. During early malignancy 1,25(OH)(2)D(3) synthesis is often enhanced to counteract hyperproliferation. In many advanced tumors, vitamin D catabolism surpasses synthesis. In vivo, expression and activity of CYP27B1 and vitamin D receptor are stimulated by (phyto)estrogens. Conversely, low nutritional calcium and folate enhance vitamin D catabolism. These insights could explain the lower colorectal cancer incidence in females, the chemopreventive potency of vitamin D and calcium against colorectal cancer, and the benefit of nutritional folate as a methyl donor for epigenetic regulation of the vitamin D system.

US$19.90

PMID: 19450178

DOI: 10.2217/fon.09.22


Other references

Wang, H.; Luo, Y.; Zhu, B.; Wu, J., 2012: Generation of cyclopenta[c]chromenes via a palladium-catalyzed reaction of 2-alkynylphenol with 2-alkynylvinyl bromide. A palladium-catalyzed tandem reaction of 2-alkynylphenol with 2-alkynylvinyl bromide gives rise to cyclopenta[c]chromenes in good yields. Three bonds are formed during the process and a double insertion of triple bonds is believed to be the key st...

Spaulding, A.; Gamm, L.; Menser, T., 2016: Physician Engagement: Strategic Considerations among Leaders at a Major Health System. The authors utilize qualitative interviews with 38 health administrators at one large metropolitan, multihospital system to help identify perspectives regarding physician engagement. Here they focus on 1) lessons learned from past physician engage...

Jeong, M.H.; Owen, W.G.; Staab, M.E.;, S., S.S.; Gregoire, J.; Wen, D.; Sangiorgi, G.; Pompili, V.J.; Stewart, M.L.u; Camrud, A.R.; Arndt, L.J.; HolmesDavid R.Jr.; Schwartz, R.S., 1995: Does ticlopidine affect platelet deposition and acute stent thrombosis?. Circulation 92(8 SUPPL ): I489

Trim, S., 2004: Embracing changes in primary health care. Nursing New Zealand 9(2): 26-26

Zhong, W.; Ye, J.; Feng, J.; Geng, L.; Lu, G.; Liu, J.; Zhang, C., 2017: Effects of Pectus Excavatum on the Spine of Pectus Excavatum Patients with Scoliosis. There is high risk in the correction surgery of pectus excavatum with scoliosis because of the lack of the correction mechanism of pectus excavatum with scoliosis. This study performed a comprehensive analysis about the impact that pectus excavatu...

Xu, Y.; Cao, C.; Chen, Z.; Li, J.; Wang, F.; Cai, H., 2006: Preparation of novel saw-toothed and riblike alpha-Si3N4 whiskers. alpha-Si(3)N(4) whiskers with novel saw-toothed and riblike structures have been synthesized in a high yield by a carbothermal reduction and nitridation route. The products were characterized by X-ray diffraction (XRD), scanning electron microscop...

Vijaikishore P.; Karanth N.G., 1986: Glycerol production by immobilized cells of pichia farinosa. Cells of Pichia farinosa were immobilised in calcium alginate and K-carrageenan and their ability to produce glycerol from glucose under aerobic conditions with acidic as well as alkaline pH was investigated. An average glycerol production rate of...

Widdison A.L.; D.G.orgio R.; Alvarez C.; Sternini C.; G.V.L.W.; Reber H.A., 1991: Relationship between pancreatic blood flow pbf and pancreatic peptide hormone immunoreactivity ir in chronic obstructive pancreatitis cp in cats. Pancreas 6(6): 723

Valenti, M.P.; Tinuper, P.; Cerullo, A.; Carcangiu, R.; Marini, C., 2000: Reading epilepsy in a patient with previous idiopathic focal epilepsy with centrotemporal spikes. Reading epilepsy (RE) is a form of reflex epilepsy currently classified as an idiopathic localization-related epilepsy (ILAE, 1989). We describe a 30 year-old right-handed male who suffered since the age of 8 from nocturnal partial motor seizures....

Potter, R.C.; DeVita, S.F.; Vranesich, P.A.; Boulton, M.L., 2014: Adolescent immunization coverage and implementation of new school requirements in Michigan, 2010. We examined the effect of Michigan's new school rules and vaccine coadministration on time to completion of all the school-required vaccine series, the individual adolescent vaccines newly required for sixth grade in 2010, and initiation of t...