+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Relationship between age and platelet activation in patients with stable and unstable angina

, : Relationship between age and platelet activation in patients with stable and unstable angina. Archives of Gerontology and Geriatrics 48(2): 155-159

The objective of this study was to examine platelet reactivity and activation as a function of age in patients with both stable and unstable angina. This was a retrospective cohort study to compare platelet function in older patients with and without acute coronary syndromes. Participants were 55 individuals presenting with acute coronary syndromes and 54 with stable angina whose age ranged from 38 to 92 years. Platelet reactivity was assessed by ADP-induced aggregation and activation was measured by p-selectin, total and active GPIIb/IIIa expression, and platelet-leukocyte aggregates in. Multiple regression was used to identify independent predictors for each platelet variable. Aggregation and receptor expression decreased with advancing age only among patients with acute coronary syndromes. In multivariate analyses, age was the strongest predictor of decreased aggregation (beta=-0.558, R(2)=0.353, p<0.0001), reduced labeling with PAC-1 (beta=-0.561, R(2)=0.276, p<0.0001) and reduced p-selectin (beta=-0.442, R(2)=0.240, p<0.0001). However, age did not predict total GPIIb/IIIa labeling or platelet-leukocyte aggregates in either acute coronary syndrome or stable patients. In conclusion, older patients with acute coronary syndromes demonstrate decreased platelet reactivity and activation at presentation. These findings may provide a mechanism to explain increased bleeding observed in elderly patients treated with GPIIb/IIIa inhibitors and fibrinolytic therapy for unstable coronary syndromes.


PMID: 18282622

DOI: 10.1016/j.archger.2007.12.006

Other references

Wilson, D.M.; Hama, H.; Wilson, T.H.stings, 1995: GLY113 fwdarw ASP can restore activity to the ASP51 fwdarw SER mutant in the melibiose carrier of Escherichia coli. ASP51 in the putative membrane-spanning helix 2 of the melibiose carrier of Escherichia coli was replaced by SER. This mutation caused failure of the cell to transport melibiose and failure to ferment melibiose on indicator plates. A melibiose-pos...

Berger, J.J.; Daniel, C.W., 1982: Diurnal rhythms in developing ducts of the mouse mammary gland. DNA synthesis (LI) and mitotic activity (MI) were studied at different times of the day in developing mammary gland end buds of 5-6-wk-old mice maintained in a 12-h light-dark cycle. Both LI and MI displayed clear diurnal variation. At the middle...

Tewari, V.K.; Prasad, N., 2000: Optimum seat pan and back-rest parameters for a comfortable tractor seat. An experimental set up was fabricated to measure the pressure distribution on the seat pan and back-rest of a tractor seat. Experiments were conducted with four different seat pans having radius of curvatures of 60, 75, 90 and infinity cm, four ba...

Djawari, D.; Hornstein, O.P.; Luckner, L., 1985: Skin window examination according to Rebuck and cutaneous pathergy tests in patients with Behcet's disease. Comparative in vivo examinations of skin (cutaneous pathergy test, skin window technique over 24 h according to Rebuck) were carried out in 12 patients with Behçet's disease (BD) and in 13 healthy volunteers serving as controls. 10 out of 12...

Davison T.F.; Misson B.H., 1987: Effect of corticosterone on antibody responses to a t dependent and t independent antigen in domestic fowl. Medical Science Research 15(16): 967-968

Lawson, Linda J., 1995: Leukocyte migration into the central nervous system. Rothwell, N J [Editor] Molecular and Cellular Neurobiology; Immune responses in the nervous system 27-59

Jorda, M.; Essenfeld, H.; Garcia, E.; Ganjei, P., 1992: The value of fine-needle aspiration cytology in the diagnosis of inflammatory pancreatic masses. In order to determine the accuracy of fine-needle aspiration cytology (FNAC) in the diagnosis of inflammatory pancreatic masses (pseudocyst and abscess), we reviewed 91 FNAC specimens performed during 1985-1989 at the University of Miami/Jackson M...

Asiodu, I.V.; Waters, C.M.; Dailey, D.E.; Lyndon, A., 2016: Infant Feeding Decision-Making and the Influences of Social Support Persons Among First-Time African American Mothers. NlmCategory="UNASSIGNED">Background While breast milk is considered the gold standard of infant feeding, a majority of African American mothers are not exclusively breastfeeding their newborn infants. Objective The overall goal of thi...

Randel, L.W.; Clary, G.M.; Randel, R.D.; Goodwin, H.L.Jr, 1994: Characterizing the demand by restaurants for exotic game meat products. Journal of Animal Science 72(SUPPL 2): 24

Guerrero M.M.; D.B.badilla J.L.F.; Peralta A.M.F.; Aguilera J.J.G., 1981: Chromosome numbers of western plants 134 137. Anales del Jardin Botanico de Madrid 38(1): 285-287