geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer


, : Relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer. International Journal of Medical Sciences 9(2): 121-125

To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET). A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from August 2009 to August 2010 were retrospectively analyzed. There was no significant difference in the days of ovarian stimulation, total gonadotropin dose, serum E2 level of HCG day and number of oocytes retrieved between the two groups. The fertilization rate, implantation rate and pregnancy rate following IVF-ET were significantly lower in women with antithyroid antibody than in control group (64.3% vs 74.6%, 17.8% vs 27.1% and 33.3% vs 46.7%, respectively), but the abortion rate was significantly higher in patients with antithyroid antibody (26.9% vs 11.8%). Patients with antithyroid antibody showed significantly lower fertilization rate, implantation rate and pregnancy rate and higher risk for abortion following IVF-ET when compared with those without antithyroid antibody. Thus, the presence of antithyroid antibody is detrimental for the pregnancy outcome following IVF-ET.

US$19.90

PMID: 22253557

DOI: 10.7150/ijms.3467


Other references

Falnes, P.O.; Rapak, A.; Olsnes, S., 1998: Toxin translocation monitored through cellular modification of peptide tags. Zentralblatt fuer Bakteriologie Supplement 29: 105-112

Taylor, W.P.; Gumm, I.D., 1985: Is the AGID test group-specific for epizootic haemorrhagic disease virus?. Progress in Clinical and Biological Research 178: 513-514

Lv, C.; Gould, T.J.; Bewersdorf, J.; Zenisek, D., 2013: High-resolution optical imaging of zebrafish larval ribbon synapse protein RIBEYE, RIM2, and CaV 1.4 by stimulation emission depletion microscopy. The synaptic ribbon is a unique presynaptic structure with an intricate morphology in photoreceptors. Because of the resolution limit in conventional fluorescence microscopy, investigating ribbon protein locations has been challenging, especially...

Mochizuki; Ikoma, 1987: New configuration-coordinate model for the ground, excited, and metastable states of EL2 in GaAs. Physical Review Letters 59(5): 590-593

Goeders, N.E., 1992: Potential involvement of anxiety in the neurobiology of cocaine. Annals of the New York Academy of Sciences 654: 357-367

Chittasupho, C.; Lirdprapamongkol, K.; Kewsuwan, P.; Sarisuta, N., 2015: Targeted delivery of doxorubicin to A549 lung cancer cells by CXCR4 antagonist conjugated PLGA nanoparticles. Doxorubicin is used to treat a variety of cancers, but dose limiting toxicity or intrinsic and acquired resistance limits its application in many types of cancer. CXCR4 is a chemokine receptor which implicates in metastasis of cancers including lu...

Gedlicka, C.; Item, C.B.; Wögerbauer, M.; Martinek, H.; Heiduschka, G.; Erovic, B.M.; C.G.asl, M.; Thurnher, D., 2010: Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations. This retrospective study was performed to evaluate the status of p53 in pleomorphic adenomas and carcinomas ex pleomorphic adenoma in the parotid gland. As loss or mutation of p53 can cause malignant transformation, the possible degeneration of pl...

Tingay, D.G.; Copnell, B.; Mills, J.F.; Morley, C.J.; Dargaville, P.A., 2007: Effects of open endotracheal suction on lung volume in infants receiving HFOV. To describe the pattern and magnitude of lung volume change during open endotracheal tube (ETT) suction in infants receiving high-frequency oscillatory ventilation (HFOV). Prospective observational clinical study. Tertiary neonatal intensive care...

Gao, J.; Woolley, F.Ross.; Zingaro, R.A., 2005: In vitro anticancer activities and optical imaging of novel intercalative non-cisplatin conjugates. The first pi-conjugated macrocyclic diimine and triaza DNA-binding intercalators and their platinum(II) conjugates have been synthesized by direct Schiff base cyclocondensation. The in vitro anticancer activities of compounds 3, 4, and 5 were test...

Kawamata, A.; Ito, D.; Odani, T.; Isobe, T.; Iwase, M.; Hatori, M.; Nagumo, M., 2006: Thalidomide suppresses melanoma growth by activating natural killer cells in mice. Although thalidomide (Thd) is being extensively investigated for its effects on cytokine production and T cell costimulation, it is poorly understood whether it is capable of modulating the activities of natural killer (NK) cells. In this study,...