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Relationships between renin, aldosterone, and 24-hour ambulatory blood pressure in obese adolescents


, : Relationships between renin, aldosterone, and 24-hour ambulatory blood pressure in obese adolescents. Pediatric Research 69(4): 336-340

Renin-angiotensin system (RAS) activation and abnormalities of ambulatory blood pressure (ABP) are present in obesity, but relationships between components of the RAS and ABP have not been defined in the young. Anthropometric measurements and 24-h ABP were obtained on 30 obese adolescents with and without type 2 diabetes mellitus. Plasma renin activity (PRA), aldosterone, and other cardiovascular risk factors were measured. Median PRA levels were 2.5 [interquartile range (IQR), 1.7-4.1] ng/mL/h and were higher in the diabetic subjects compared with the nondiabetics. Females had significantly higher PRA than males 3.2 (IQR, 2-4.8) versus 1.8 (IQR, 1.1-2.9) ng/mL/h (p = 0.04) and were more obese. BMI Z score and PRA were significantly correlated (rho = 0.46, p < 0.001). PRA inversely correlated with 24-h systolic ABP (rho = -0.46, p = 0.02) and strongly with 24-h pulse pressure (rho = -0.61, p = 0.001). Aldosterone levels were also correlated with 24-h pulse pressure (rho = -0.46, p = 0.02). In multivariate models, lower PRA was independently associated with 24-h systolic blood pressure. In this study, PRA was positively correlated with BMI, but the relationships between components of the RAS and ABP were inverse. Further studies are needed to define the pathophysiologic relationship between RAS components and blood pressure regulation in obese youth.

US$19.90

PMID: 21178817

DOI: 10.1203/PDR.0b013e31820bd148


Other references

Kraft, D.; Werner, H.P.; Stemberger, H.; Wiedermann, G., 1972: Detection of human anti-penicillin antibodies of IgE type by means of immunfluorescence and PCA in monkey skin. Zeitschrift für Immunitatsforschung, Experimentelle und Klinische Immunologie 144(4): 389-395

Harris, J.R.W., 1983: The development and growth of Calanus copepodites. Limnology and Oceanography 28: 2-7

Wenzel, M.; Wu, Y., 1988: Ferrocene, ruthenocene and rhodocene analogs in haloperidol synthesis and organ distribution after labeling with 103Ru and 103mRh. Ferrocene-Haloperidol was synthesized by N-alkylation of 4-(4'-chlorophenyl)- 4-hydroxypiperidine with 1-ferrocenyl-4-chlor-butan-1-on. By heating the ferrocene-haloperidol with 103RuCl3 the 103Ru-labelled ruthenocene-haloperidol was obtained...

Zhang, B.; Tang, P-zhang., 2011: Introduction to "NCCN clinical practice guidelines in head and neck cancer (2009 Chinese version)". Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44(9): 707-709

Lenz, F.; Vogt, M.; Bollmann, R., 2011: The Whirlpool sign in the diagnosis of fetal volvulus. Ultraschall in der Medizin 31(6): 612-613

Zayeri, F.; Kazemnejad, A.; Ganjali, M.; Babaei, G.; Khanafshar, N.; Nayeri, F., 2005: Hypothermia in Iranian newborns. Incidence, risk factors and related complications. Objective: To determine the incidence rate and factors associated with hypothermia in Iranian newborns and to discover the effect of hypothermia on neonatal morbidity and mortality.Methods: We selected a random sample of 1952 neonates using a mult...

Schumacher, T., 1978: A guide to the amenticolous species of the genus ciboria in norway. Species [6] of ament-attacking Ciboria species are recorded for the 1st time from Norway: C. acerina, C. alni, C. betulae, C. betulicola, C. caucus and C. coryli. Of these, C. betulicola was previously known only from North America. C. amentacea (...

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