+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Relevance and methods of interventional breast sonography in preoperative axillary lymph node staging

, : Relevance and methods of interventional breast sonography in preoperative axillary lymph node staging. Ultraschall in der Medizin 33(4): 337-343

Reduction of therapy-induced morbidity is an important goal for the improvement of the quality of breast cancer treatment. The introduction of sentinel lymph node biopsy (SLNB) significantly contributed to the reduction of surgery-induced morbidity in the shoulder-arm region. However, a clinically positive nodal status is still considered a contra-indication for SLNB. The current data constellation clearly shows that the clinical and also the sonographic malignancy assessment is insufficient for the accurate identification of the nodal status. A merely clinical and/or image-based appraisal of the axillary lymph node status would lead to overtreatment due to unnecessary axillary dissection in approximately 40 % of patients. In order to reduce the rate of unnecessary axillary dissection (AD), pretreatment interventional clarification is necessary to provide more detailed information about the histological condition of the lymph node. Comparing the currently available methods, fine needle aspiration (FNA) is the best in terms of cost and time requirement, practicability and complication rate. However, considering the sensitivity, it is inferior to ultrasound-guided core needle biopsy (CNB). Thus, a negative FNA outcome requires further clarification, which possibly can be performed with CNB. With a specificity of nearly 100 % and therefore a low rate of false positive cases for FNA, complete AD can be indicated by a positive FNA result. In the context of the interventional procedure, it must be stressed that FNA requires a high level of expertise on the part of both the examiner and the cytologist. The prerequisite for optimal interventional diagnostics of lymph nodes is an adequate sonographic assessment on the basis of standardized sonomorphological criteria.


PMID: 21618166

DOI: 10.1055/s-0031-1273317

Other references

Smith D.J.; Daley G., 1988: Chronic ethanol e consumption decreases alanine uptake by rat basolateral liver plasma membrane blpm vesicles. Gastroenterology 94(5 PART 2): A593

Mariño del Real, J.; Senovilla Pérez, J.L.; Mateos Blanco, J.; Abengozar García-Moreno, A.; Sevilla Zabaleta, M.; Caballero Gómez, M.; Cabello Padial, J.; Murillo Mirat, J., 2001: Fracture of the penis. Review of the literature and presentation of 2 cases. We report two cases of a very uncommon pathology as is the rupture of the corpus cavernosum of the penis, undergoing early surgical management with good results. We also review the diagnostic, clinical and etiological aspects, and the most appropr...

Cai, Z.; Finnie, J.W.; Blumbergs, P.C., 2006: Avian riboflavin deficiency: an acquired tomaculous neuropathy. The finding of tomacula, focal areas of sausage-shaped hypermyelination in peripheral nerves, is reported for the first time in avian riboflavin deficiency. Day-old, meat-type chickens were fed a riboflavin-deficient diet (1.8 mg/kg) and were kill...

Planesse, C.; Nativel, B.; Iwema, T.; Gasque, P.; Robert-D.S.lva, C.; Viranaïcken, W., 2015: Recombinant human HSP60 produced in ClearColi™ BL21(DE3) does not activate the NFκB pathway. HSP60, an intracellular molecular chaperone has been largely described as an alarmin or damage-associated molecular pattern when released outside the cell. HSP60 has been reported as a possible ligand of TLR2 or TLR4 inducing NFκB-dependant signa...

Saygi, M.; Haydin, S.; Guzeltas, A.; Odemis, E.; Yeniterzi, M., 2015: A rare congenital cardiac anomaly in adulthood: tetralogy of Fallot with absent pulmonary valve syndrome. In approximately 3% to 6% of the patients with tetralogy of Fallot (TOF), the pulmonary valve leaflets are absent or only a rudimentary ridge of tissue is present. Some infants with the severe form of this syndrome die early during the newborn per...

Yoshihama, M.; Horrocks, J., 2002: Posttraumatic stress symptoms and victimization among Japanese American women. This study of Japanese American women and immigrant women from Japan investigated the relationship between posttraumatic stress (PTS) symptoms and the perceived abusiveness of partners' emotional and physical violence, with a community-based...

Mistry, A., M.; Helferich, W.; Romsos, D., R., 1994: Elevated neuronal c-fos-like immunoreactivity and messenger ribonucleic acid (mRNA) in genetically obese (ob/ob) mice. Adult genetically obese (ob/ob) mice display a number of metabolic alterations, the primary cause of which may be a defect in their central nervous system (CNS). The protein encoded by the protooncogene c-fos, c-Fos, functions as a nuclear transcr...

Miot-Noirault, E.; Papon, J.; Gardette, M.; Bonnet-Duquennoy, M.; Labarre, P.; Maisonial, Aélie.; Madelmont, J-Claude.; Maublant, J.; Chezal, J-Michel.; Moins, N., 2010: The use of [(125)I] scintigraphic in vivo imaging in melanoma-bearing mice for a rapid prescreening of vectors to melanoma tissue. The use of radiolabeled molecules allows the study of in vivo biodistribution, target organs, and kinetic profile after systemic administration by 1) radioactive organ counting and 2) quantitative autoradiographic analysis of whole-body slices (WB...

Belles, X.F.vila, M., 1983: Chemical protection of the nest by Canthon cyanellus cyanellus LeConte (Coleoptera Scarabaeidae). Bulletin Societe entomologique de France 88(7-8): 602-607

Chibber B.A.K.; Mertz E.T.; Viswanatha T., 1975: The kinetics of strepto kinase mediated activation of plasminogen and its auto activation in the presence of creatine. Federation Proceedings 34(3): 258