geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Replacement of carvedilol for propranolol in patients with heart failure


, : Replacement of carvedilol for propranolol in patients with heart failure. Arquivos Brasileiros de Cardiologia 95(1): 107-114

Large clinical trials using the betablockers carvedilol, metoprolol, bisoprolol and nebivolol have demonstrated improvement of survival and symptoms in patients with heart failure. Despite the lack of scientific evidence, it is plausible that their beneficial effects are extensible to other betablockers. To evaluate the impact of the replacement of carvedilol for propranolol on left ventricular function, functional capacity, quality of life, pressure levels, and cardiac autonomic control in patients with heart failure. Twenty nine patients receiving optimized drug therapy including maximum tolerated doses of carvedilol were divided into two groups: replacement of carvedilol for propranolol (n = 15) and continued carvedilol (n = 14). At baseline and 6 months later, clinical and laboratorial assessments were carried out with radionuclide ventriculography, echocardiography, Minnesota questionnaire, walk test, APBM and Holter monitoring. The clinical and demographic characteristics were similar in the two groups at baseline. Individualized propranolol dose adjustment ensured a similar degree of beta-blockade, as assessed by resting heart rate and chronotropic reserve. The mean propranolol dose used was 109 +/- 43 mg/day. Only one patient presented with intolerance to propranolol, thus carvedilol was reintroduced. One death was recorded in group propranolol. Ejection fraction significantly increased in the propranolol group. No significant change was observed in the other cardiovascular variables after betablocker replacement. Our results indicate that replacement of carvedilol for propranolol in patients with heart failure is not associated with deterioration of the ejection fraction, functional capacity, quality of life, and other cardiovascular variables related to autonomic and blood pressure control., PP.0-0).

US$29.90

PMID: 20563524


Other references

Cannon David L.; Noll Mark R., 2004: Geochemical evidence for dolomitization along the Clarendon Linden Fault in western New York. Dolomitization after initial lithification of carbonate rocks is achieved through fluid flow and a replacement of pre-existing carbonate components producing saddle dolomite. This geochemical process has been documented in the Western Canadian Sed...

Singh, G., 2010: Revisualizing visualization. IEEE Computer Graphics and Applications 29(5): 4-5

Kubota, SS.; Amano, H.; Ichioka, M.; Miyazaki, T.; Niwa, M., 1981: Methemoglobinemia in Japanese eel. Bulletin of the Faculty of Fisheries Mie University, 149-161 No. 8

Kanda, N.; Nakajima, M.; Fujio, Y., 1992: Genetic variation for thermal resistance of the guppy, Poecilia reticulata. 10 populations of guppies, each derived from matings of 1 gravid [female] with 1 [male], were studied. The distribution in survival time of immature fish after exposure to a temp. of 37 degrees C showed wide variation, with 2 peaks in some of the...

Tordera, J., 1988: The body as an outlet. Reflections on psychosomatic diseases. Revue Medicale de la Suisse Romande 108(10): 871-880

Baraona E.; Pirola R.C.; Lieber C.S., 1973: Ethanol damages the small intestine and changes its cell population. Journal of Clinical Investigation 52(6):

Baker, M.M.; Belal, T.S., 2017: Validated HPLC-DAD Method for the Simultaneous Determination of Six Selected Drugs Used in the Treatment of Glaucoma. This work presents a simple, sensitive, and generic HPLC–diode-array detection method for the simultaneous determination of six drugs prescribed for the treatment of open-angle glaucoma and ocular hypertension. The investigated drugs inc...

Sternfeldt, S., 1979: The turtle dove occurrence in Helsingborg during winter 1973-74 & 1978-79. Anser, 183: 197-200

Natkina, A.I., 1940: Investigation of the composition and properties of the humic acids in a chernozem and in a podzol soil.. The humic acids from the two soils were compared by a study of their elementary composition and by determining the number of carboxyl and hydroxyl groups by methylation. A considerable difference was found in the elementary composition of the two...

Hodges, N.J.; Smart, D.; Lee, A.J.; Lewis, N.A.; Chipman, J.K., 2004: Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin. Changes in the components of the Jun N-terminal kinase (JNK) signalling pathway were investigated in human A549 lung carcinoma cells treated with sodium dichromate. Sodium dichromate (100 microM, 0-6h) failed to activate nuclear factor kappa B (NF...