+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Restricted access to the environment and quality of life in adult survivors of childhood brain tumors

, : Restricted access to the environment and quality of life in adult survivors of childhood brain tumors. Journal of Neuro-Oncology 111(2): 195-203

Survivors of pediatric brain tumors (BTs) are at-risk for late effects which may affect mobility within and access to the physical environment. This study examined the prevalence of and risk factors for restricted environmental access in survivors of childhood BTs and investigated the associations between reduced environmental access, health-related quality of life (HRQOL), and survivors' social functioning. In-home evaluations were completed for 78 BT survivors and 78 population-based controls matched on age, sex, and zip-code. Chi-square tests and multivariable logistic regression models were used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) for poor environmental access and reduced HRQOL. The median age of survivors was 22 years at the time of study. Compared to controls, survivors were more likely to report avoiding most dimensions of their physical environment, including a single flight of stairs (p < 0.001), uneven surfaces (p < 0.001), traveling alone (p = 0.01), and traveling to unfamiliar places (p = 0.001). Overall, survivors were 4.8 times more likely to report poor environmental access (95 % CI 2.0-11.5, p < 0.001). In survivors, poor environmental access was associated with reduced physical function (OR = 3.6, 95 % CI 1.0-12.8, p = 0.04), general health (OR = 6.0, 95 % CI 1.8-20.6, p = 0.002), and social functioning (OR = 4.3, 95 % CI 1.1-17.3, p = 0.03). Adult survivors of pediatric BTs were more likely to avoid their physical environment than matched controls. Restricted environmental access was associated with reduced HRQOL and diminished social functioning. Interventions directed at improving physical mobility may have significant impact on survivor quality of life.


PMID: 23143294

DOI: 10.1007/s11060-012-1001-6

Other references

Wahl, R.R.ff, J.S.lenska-Pobell, S.M.rtig, M.P.mpe, W., 2001: A fast screening method for surface layers on Gram-positive bacteria. A two-step screening method is described to identify regularly arranged surface layers (S layers) on Gram-positive bacterial strains. A non-destructive release of S-layer sheets is achieved by enzymatic hydrolysis of the underlying peptidoglycan u...

Kabos, W.J., 1959: Dipterologische onderzoekingen in graslanden. Entomologische Berichten Amsterdam, 19: 207-210

Li, X-mei.; Li, J., 2004: Environmental hormones and their effects on human health. Zhonghua Yu Fang Yi Xue Za Zhi 37(3): 209-211

Swalve, H.H.; Hover, K., 2003: Examinations using the results of breeding value estimation for Holstein sires and cows in Germany. Besides being used for selection purposes, estimated breeding values can be used to analyse genetic trends and structures in populations. Using data from 2 440 261 cows from four regions in Germany, the genetic trends for all cows under test (regi...

Hashimoto, K.; Murakami, K.; Ohno, N.; Kageyama, J.; Aoki, Y.; Takahara, J.; Ota, Z., 1983: A specific radioimmunoassay for corticotropin releasing factor (CRF) using synthetic ovine CRF. This newly developed specific radioimmunoassay for corticotropin releasing factor (CRF) had a sensitivity range of 25 pg/tube to 4 ng/tube. Intra and interassay coefficient of variation were 4.6% and 9.8%, respectively. Rat median eminence extract...

Tartinville, B.; Rancher, J., 2000: Wave-induced flow over Mururoa atoll reef. A unique long-term timeseries of current over Mururoa atoll reef is presented here. Comparison with TOPEX/POSEIDON satellite altimeter data reveals that the daily-averaged cross-reef current is wave-driven and varies at the synoptic time scale. Th...

Nutahara, K.; Higashihara, E., 2000: Prostate specific antigen: a role of PSA in the diagnosis of prostate cancer. Nihon Rinsho. Japanese Journal of Clinical Medicine 58 Suppl: 95-98

Kawano, T., 1934: Studies on the Life-history of Epilachna admirabilis, Crotch.. Descriptions are given of all stages of the Coccinellid, Epilachna admirabilis, Crotch, which feeds on various cucurbits, including Trichosanthes cucumeroides, Momordica charantia, Luffa cylindrica, etc., and also, in both adult and larval stages,...

Preobrazhenskiĭ, V.N.; Klimov, N.P.; Katkov, V.I.; Bazhanov, V.L.; Degoeva, B.A.; Kiselev, S.D., 1991: The treatment of patients with long-term nonhealing duodenal ulcers combined with chronic gastric erosions in the presence of Helicobacter pylori. Data are reported of the efficacy of different drugs in the treatment 66 patients with prolonged nonhealing duodenal ulcers in association with chronic erosions in the presence of Helicobacter pylori. It was found that a concentrate of granulocyte...

Badr M.Z.A.; E.S.erief H.A.H.; E.N.ggar G.M.; Mahmoud A.M., 1979: Synthesis of thiazolyl quinazolin 4 3h ones. Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 18(6): 560-563