+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release

, : Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release. Evidence-Based Complementary and Alternative Medicine 2012: 937605-937605

Increasing evidence indicated astroglia-derived neurotrophic factors generation might hold a promising therapy for Parkinson's disease (PD). Resveratrol, naturally present in red wine and grapes with potential benefit for health, is well known to possess a number of pharmacological activities. Besides the antineuroinflammatory properties, we hypothesized the neuroprotective potency of resveratrol is partially due to its additional neurotrophic effects. Here, primary rat midbrain neuron-glia cultures were applied to investigate the neurotrophic effects mediated by resveratrol on dopamine (DA) neurons and further explore the role of neurotrophic factors in its actions. Results showed resveratrol produced neurotrophic effects on cultured DA neurons. Additionally, astroglia-derived neurotrophic factors release was responsible for resveratrol-mediated neurotrophic properties as evidenced by the following observations: (1) resveratrol failed to exert neurotrophic effects on DA neurons in the cultures without astroglia; (2) the astroglia-conditioned medium prepared from astroglia-enriched cultures treated with resveratrol produced neurotrophic effects in neuron-enriched cultures; (3) resveratrol increased neurotrophic factors release in the concentration- and time-dependent manners; (4) resveratrol-mediated neurotrophic effects were suppressed by blocking the action of the neurotrophic factors. Together, resveratrol could produce neurotrophic effects on DA neurons through prompting neurotrophic factors release, and these effects might open new alternative avenues for neurotrophic factor-based therapy targeting PD.


PMID: 23304227

DOI: 10.1155/2012/937605

Other references

Bruttomesso, D.; Biolo, G.; Inchiostro, S.; Fongher, C.; Briani, G.; Duner, E.; Marescotti, M.C.; Iori, E.; Tiengo, A.; Tessari, P., 1991: No effects of high-fiber diets on metabolic control and insulin-sensitivity in type 1 diabetic subjects. The metabolic effects of a three-month treatment with a high-fiber diet (15 grams of guar-gum added to a standard diet) were investigated in seven type 1 diabetic subjects, with a moderately poor metabolic control. HbA1c levels, daily insulin requ...

Malan T.P.Jr; Kadota Y.; Mata H.; Frink E.J.Jr; Brown B.R.Jr, 1992: Indices of renal tubular damage after sevoflurane anesthesia in the fischer 344 rat. Anesthesiology (Hagerstown) 77(3A): A358

Griffin, A.; Brito, J.P.; Bahl, M.; Hoang, J.K., 2017: Applying Criteria of Active Surveillance to Low-Risk Papillary Thyroid Cancer Over a Decade: How Many Surgeries and Complications Can Be Avoided?. The 2015 American Thyroid Association guidelines acknowledged that "an active surveillance management approach can be considered as an alternative to immediate surgery" in patients with low-risk papillary thyroid carcinoma (PTC). The aim...

Isetti, G.; Maurer, M.C., 2007: Employing mutants to study thrombin residues responsible for factor XIII activation peptide recognition: a kinetic study. In the last stages of coagulation, thrombin helps to activate Factor XIII. The resultant transglutaminase introduces covalent cross-links into fibrin thus promoting clot stability. To better understand the roles of individual thrombin residues in...

Teo, S.K.; Scheffler, M.R.; Kook, K.A.; Tracewell, W.G.; Colburn, W.A.; Stirling, D.I.; Thomas, S.D., 2001: Thalidomide dose proportionality assessment following single doses to healthy subjects. Thalidomide is approved in the United States for treating erythema nodosum leprosum, a complication of leprosy. The present study determined the single-dose oral pharmacokinetics and dose proportionality from 50 to 400 mg of Celgene's commerc...

Ifuku, K.; Sato, F., 2002: A truncated mutant of the extrinsic 23-kDa protein that absolutely requires the extrinsic 17-kDa protein for Ca2+ retention in photosystem II. One function of the extrinsic 23-kDa protein in photosystem II (OEC23) is to retain Ca(2+ )and Cl(-), two essential cofactors for photosynthetic oxygen evolution. A truncated mutant of OEC23 (OEC23 Delta19) revealed that 19 residues of the N-termi...

Chandrashekar, V.; Bartke, A., 1998: The role of growth hormone in pituitary and testicular function in adult mice. Biology of Reproduction 58(SUPPL 1): 98

Jochem, W., 1974: Radiological signs of bronchial carcinoma in thorax general radiograph. Rontgen-Blatter; Zeitschrift für Rontgen-Technik und Medizinisch-Wissenschaftliche Photographie 27(4): 165-172

Morgan, B.A.; Finnegan, N.M.; Prevost, G.; Cotter, T.G., 2000: Peptides which mimic the BH3 domain of pro-apoptotic products of the BCL-2 gene family induce apoptosis in prostate carcinoma cells. Proceedings of the American Association for Cancer Research Annual Meeting (41): 739, March

Kim, C.; Lee, M.H., 1970: Muscular dystrophy and sarcoidosis. New York State Journal of Medicine 70(18): 2354-2358