+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Review of high-dose intravenous vitamin C as an anticancer agent

, : Review of high-dose intravenous vitamin C as an anticancer agent. Asia-Pacific Journal of Clinical Oncology 10(1): 22-37

In the 1970s, Pauling and Cameron reported increased survival of patients with advanced cancer treated with high-dose intravenous (IV) vitamin C (L-ascorbate, ascorbic acid). These studies were criticized for their retrospective nature and lack of standardization of key prognostic factors including performance status. Subsequently, several well-designed randomized controlled trials failed to demonstrate a significant survival benefit, although these trials used high-dose oral vitamin C. Marked differences are now recognized in the pharmacokinetics of vitamin C with oral and IV administration, opening the issue of therapeutic efficacy to question. In vitro evidence suggests that vitamin C functions at low concentrations as an antioxidant but may have pro-oxidant activity at high concentrations. The mechanism of its pro-oxidant action is not fully understood, and both intra- and extracellular mechanisms that generate hydrogen peroxide have been proposed. It remains to be proven whether vitamin C-induced reactive oxygen species occur in vivo and, if so, whether this will translate to a clinical benefit. Current clinical evidence for a therapeutic effect of high-dose IV vitamin C is ambiguous, being based on case series. The interpretation and validation of these studies is hindered by limited correlation of plasma vitamin C concentrations with response. The methodology exists to determine if there is a role for high-dose IV vitamin C in the treatment of cancer, but the limited understanding of its pharmacodynamic properties makes this challenging. Currently, the use of high-dose IV vitamin C cannot be recommended outside of a clinical trial.


PMID: 24571058

DOI: 10.1111/ajco.12173

Other references

Blanchi, A.; Bour, B.; Alami, O., 1995: Spontaneous gastrosplenic fistula revealing high-grade centroblastic lymphoma: endoscopic findings. Gastrointestinal Endoscopy 42(6): 587-589

Heyl George Richard, 1948: The zinc-copper mines of the Quail Hill area, Calaveras County, California. Pages 111-126:

Osada, K.; Kojima, T.; Kobayashi, K., 1984: Lasers in dentistry. 4. Experimental studies on Nd-YAG laser. Shikai Tenbo 64(1): 173-192

Pahwa, T.R., 1941: "Prognosis in sarcoma of the Uvea". British Journal of Ophthalmology 25(6): 241-286

Ferrari, G.; Degiuseppe, L.; Ventura, U., 1963: Action Of Some Structural Antagonists Of Thiamine And Their Derivatives On Carboxylase From Yeast. Bollettino Della Societa Italiana di Biologia Sperimentale 39: 1843-1846

Garrido, M.; Pérez-Mellado, V., 2013: Prevalence and intensity of blood parasites in insular lizards. Parasites are important in understanding population dynamics and ecology of hosts. In several Mediterranean islands, little is known about lizards blood parasites. We studied the relations between haemoparasites and an endemic lizard host, <ita...

McAlister, C.; Schmitter-Edgecombe, M., 2016: Everyday functioning and cognitive correlates in healthy older adults with subjective cognitive concerns. Few studies have examined functional abilities and complaints in healthy older adults (HOAs) with subjective cognitive concerns (SCC). The aims of this study were to assess everyday functioning in HOAs reporting high and low amounts of SCC and exa...

Shonkwiler, J.S., 1980: A semi-annual econometric model of the United States feed grain-livestock economy. A feed-livestock sectoral model was formulated to permit analyses of the predictive value of a large scale econometric system for agriculture. A linear, fairly simple structural specification was adapted in an effort to avoid over modelling areas...

Ronda R.; Joffre J., 1975: Production of bovine anti erythrocytic serum. Revista Cubana de Ciencias Veterinarias 5(1/2): 105-112

Dean, S.W., 1991: Corrosion engineering in the chemical process industries-a story of significant success. Corrosion engineering has played a crucial role in the chemical process industries in ensuring safe, reliable operation in spite of the many corrosive and difficult chemicals that are handled. Corrosive chemicals including sulfuric acid, nitric ac...