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Risk of second malignancies in patients with gastric marginal zone lymphomas of mucosa associate lymphoid tissue (MALT)

, : Risk of second malignancies in patients with gastric marginal zone lymphomas of mucosa associate lymphoid tissue (MALT). Journal of Gastroenterology 49(5): 843-852

It is controversial whether patients with gastric marginal zone lymphomas of mucosa associated lymphoid tissue (MALT) have higher risk of second malignancies. The aim of this study was to define the risk of second malignancies in these patients. We analyzed prospective follow-up data of 146 consecutive patients with gastric MALT lymphoma treated at Aichi Cancer Center Hospital and compared the incidence of second malignancies with that in the general population. We calculated the standardized incidence ratio (SIR), using age- and sex-specific incidence rates from the Aichi Cancer Registry. The median follow-up period was 74 months. A total of 27 tumors occurred in 22 patients (15.1%), including 19 solid tumors. Of these, nine tumors were detected concomitantly with, and 18 tumors following, the diagnosis of gastric MALT lymphoma. Four patients had two second malignancies each. For the entire group, the SIR of an additional malignancy was 3.39 (95% confidence interval [CI] 2.11-4.66). An increased incidence of solid tumors (SIR 2.91 [1.60-4.22]) and hematologic malignancies (SIR 5.54 [1.70-9.38]) were seen. In addition, there was increased risk for development of second malignancies during follow up (SIR 2.26 [1.21-3.30]). Chemotherapy for treatment of MALT was an independent risk factor for second malignancies (age-sex adjusted hazard ratio 3.98 [1.47-10.79]. Compared with the general population, patients with gastric MALT lymphoma are at increased risk for second malignancies, including gastric cancer.


PMID: 23793380

DOI: 10.1007/s00535-013-0844-8

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Löscher, W., 2012: Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have been instrumental in the discovery and preclinical development of novel a...

Beuzenberg, M.P., 1982: Compact growth, little dwarfing and quick flowering. Trials with new and established Hibiscus rosa-sinensis cultivars, including some raised at Wageningen, are discussed briefly. Treatment with a growth retardant such as Cycocel [chlormequat] was essential for compact growth and good flowering, but...

Gatti, J.Chen., 2004: Exercise-based rehabilitation for coronary heart disease. American Family Physician 70(3): 485-486

Phillips, R.S.; Scott, B.; Carter, S.J.; Taylor, M.; Peirce, E.; Davies, P.; Maconochie, I.K., 2016: Systematic review and meta-analysis of outcomes after cardiopulmonary arrest in childhood. Cardiopulmonary arrest in children is an uncommon event, and often fatal. Resuscitation is often attempted, but at what point, and under what circumstances do continued attempts to re-establish circulation become futile? The uncertainty around the...

Noguera, H.; Ruiz, H.; Saavedra, J.; Quiroga, J., 1967: Effects of amyl nitrite on the left atrium pressure in patients with mitral valve involvement. Recording of left atrial pressure by transeptal catheterization was made after inhalation of amyl nitrite in 12 individuals suffering from predominant mitral stenosis or insufficiency. Increase in atrial pressure was observed in 5 of 6 cases with...

Barnich, R.; Fiege, D.; Micaletto, G.; Gambi, M.C., 2006: Redescription of Harmothoe spinosa Kinberg, 1856 (Polychaeta: Polynoidae) and related species from Subantarctic and Antarctic waters, with the erection of a new genus. During the expeditions ANT XIII/3 (1996) and ANT XV/3 (1998) to the Weddell Sea, a number of polynoid specimens resembling Harmothoe spinosa Kinberg, 1856 were collected. Due to contradictory information in the literature regarding the differentia...

Marques T.M., 1978: Geological and geophysical investigations for lead exploration in Jurema Plantation, Barra da Estiva, Bahia. Anais do Congresso 30, Vol

Mamet, Bl, 1976: Biostratigraphy and regional relations of the Mississippian Leadville Limestone in the San Juan Mountains, southwestern Colorado. Professional PapGeol. Surv: 1-25

Severo, L.C., 1996: Actinomycotic intracavity lung colonisation. Thorax 51(11): 1168-1168

Taylor A.Jr; Akiya F.; Gregory M.C., 1986: Failure to visualize acutely injured kidneys with technetium 99m dimercaptosuccinic acid does not preclude recoverable function. Journal of Nuclear Medicine 27(3): 377-379