+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Rituximab as an effective alternative therapy in refractory idiopathic inflammatory myopathies

, : Rituximab as an effective alternative therapy in refractory idiopathic inflammatory myopathies. Clinical and Experimental Rheumatology 31(6): 896-903

To assess the efficacy and safety of B-lymphocyte depletion therapy (BCDT) utilising rituximab in refractory idiopathic inflammatory myositis. We retrospectively evaluated 16 adult patients with active dermatomyositis (DM) or polymyositis (PM) who received 1 gram rituximab intravenous infusions two weeks apart after failing to respond to conventional therapy. The clinical and biochemical response were analysed by the Myositis Intention to Treat index (MITAX) and the serum creatine kinase (CK) levels at baseline and 6 and 12 months after treatment. The primary efficacy outcome was 20% improvement in the MITAX index and 30% reduction in CK. Eight patients responded to treatment and achieved both the MITAX and CK levels objectives within 6 months of rituximab therapy. Five out of these 8 responders remained clinically stable at 12 months and CK levels were still reduced or normalised. Of note, 4 patients who did not respond were re-assessed and had their diagnoses corrected. All patients showed adequate B cell depletion (BCD) with re-population occurring for a 15.4 months average (range 3-42 months). Those simultaneously treated with cyclophosphamide achieved more long-lasting depletion (average 18.6 months). The heterogeneous clinical and serological characteristics of patients diagnosed with IIM probably explain why some, but not all patients respond to rituximab. Myositis overlap and anti-synthetase syndromes seem to respond better than other patient subsets.


PMID: 24050676

Other references

Jose Mathew; Johari, B.N., 1988: Propagation of vesicular-arbuscular mycorrhizal fungi in moong (Vigna radiata L.) through nutrient film technique (NFT). Details are given of a NFT system for multiplication of Glomus caledonium, G. fasciculatum, Gigaspora margarita and Gigaspora calospora on V. radiata. The effects of NFT-grown V. radiata inoculum on pot grown maize plants were recorded, G. fascicu...

Kalimo H., 1971: Ultrastrucutral studies on the hypothalamic neuro secretory neurons of the rat part 1 the paraventricular neurones of the nontreated rats. Zeitschrift fuer Zellforschung und Mikroskopische Anatomie 122(3): 283-300

Dasso, L.L.T.; Buckler, K.J.; Vaughan Jones, R.D., 1996: Effects of cholinergic agonists on intracellular Ca-2+ in neonatal rat carotid body type I cells. Journal of Physiology (Cambridge) 493P(0): 17P

Lieberman, M.W.; Forbes, P.D., 1973: Demonstration of DNA repair in normal and neoplastic tissues after treatment with proximate chemical carcinogens and ultraviolet radiation. Nature: New Biology 241(111): 199-201

Conrad, C.D., 2010: A critical review of chronic stress effects on spatial learning and memory. The purpose of this review is to evaluate the effects of chronic stress on hippocampal-dependent function, based primarily upon studies using young, adult male rodents and spatial navigation tasks. Despite this restriction, variability amongst the...

Berenji, K.; Nerheim, P.; Olshansky, B., 2003: Inadvertent positioning of pacemaker leads in the pericardium. A patient had a dual chamber pacemaker with endocardial leads implanted chronically. The lead position on chest X ray and the ECG pattern indicated lead malposition, but a CT scan and transesophageal echocardiography were nondiagnostic. Venography...

Caggese, C.B.zzetti, M.P.lumbo, G.B.rsanti, P., 1983: Induction by hydrocortisone-21-sodium succinate of the 70K heat-shock polypeptide in isolated salivary glands of Drosophila melanogaster larvae. Experientia 39(10): 1143-1144

Vershilova, P.A., 1954: The properties of immuno-genesis in the vaccination with living brucellosis vaccine. In guinea pigs vaccinated with live brucellosis vaccine antibodies begin to appear with the first injection of the vaccine. Antibody formation depends upon the quality and dose of the vaccine. In the immune organism brucella infections develop 30-...

Trani, S.; Novello, E., 1976: Bidimensional I.E.F. of proteins in the bronchial secretion. Qualitative and quantitative determination of the proteins in the bronchial secretions (of about 50 patients suffering from chronic bronchitis) after extraction.

Alam, A.; Hardjosuwito, B., 1989: A modified hammermilling huller for dried coffee cherries. A hammer mill huller was modified and performed satisfactorily. When used on dried coffee cherries of 13-15% m.c., the number of broken beans produced was similar to those produced by the unmodified model. However, the capacity is higher. Being op...