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Role of genetic pattern on bone mineral density in thalassemic patients

, : Role of genetic pattern on bone mineral density in thalassemic patients. Clinical Biochemistry 43(10-11): 805-807

To evaluate the role of genetic background in osteoporosis/osteopenia development in beta-Thalassemia Major patients. The influence of VDR (FokI, BsmI) as well as COLIA1 (Sp1) gene polymorphisms on BMD was investigated in 40 patients. Although the examined gene polymorphisms did not significantly affect BMD variations in our population, BsmI was found to display beneficial effects on patient response to alendronate therapy. Genetic factors retain a potential role for improvement of osteoporosis management in thalassemic patients.


PMID: 20444423

DOI: 10.1016/j.clinbiochem.2010.04.070

Other references

Israfilbeĭli, S.G.; Babaev, F.F., 2006: Functional state of kidneys and upper urogenital tract in patients with intraligamentary ovarian cysts in pre and postoperative periods during the treatment with spasmolytics. 25 patients with different types of intraligamentary ovarian cysts were observed. The main diagnostic method of the patients with intraligamentary cysts was ultrasound Dopplerometry of arteries iliaca interna, uterine and renalis using the followi...

Fomina, V.; Telishevskii, D.; Khorechko, A., 1980: Experience of plantation growing of Pleurotus ostreatus. Lesnoe khoziaistvo: 1) 73-74

Kottke I., 1991: Electron energy loss spectroscopy and imaging techniques for subcellular localization of elements in mycorrhiza. Norris, J R , D J Read And A K Varma (Ed ) Methods in Microbiology, Vol 23 Techniques For The Study Of Mycorrhiza Xi+480p Academic Press Ltd : London, England, Uk; San Diego, California, Usa Illus 369-382

Dembek, Z.F.; Smith, L.A.; Rusnak, J.M., 2008: Botulism: cause, effects, diagnosis, clinical and laboratory identification, and treatment modalities. Botulism is a neuroparalytic disease caused by neurotoxins produced by the bacteria Clostridium botulinum. Botulinum neurotoxins (BoNTs) are among the most potent naturally occurring toxins and are a category A biological threat agent. The 7 toxin...

Berger, E.D.; Bader, B.D.; Ebert, C.; Risler, T.; Erley, C.M., 2000: Reduction of proteinuria in glomerulonephritis Additional effects of an AT1-receptor antagonist in patients primarily treated with an ACE-inhibitor. Kidney & Blood Pressure Research 23(3-5): 283-284

Borges, C.P.; Meyer, E.; Ferrão, Y.A.; Souza, F.P.; Sousa, M.B.; Cordioli, A.V., 2011: Cognitive-behavioral group therapy versus sertraline for obsessive-compulsive disorder: five-year follow-up. PsychoTherapy and Psychosomatics 80(4): 249-250

Potter, AW., 1990: The Ordovician brachiopod genus Bimuria from the eastern Klamath Mountains, northern California. The genus Bimuria Ulrich and Cooper, 1942, is a biogeographically important member of middle and late Ordovician brachiopod faunas of the Callahan-Gazelle area in the eastern Klamath Mountains of northern California. In middle Ordovician deposits...

Morozov, D.A.; Filippov, I.V.; Gorodkov, S.Iu.; Kliuev, S.A., 2011: Syndrome of intraabdominal hypertension. Vestnik Khirurgii Imeni I. I. Grekova 170(1): 97-101

Neto E.V.S.ntos; Hayes J.M.; Trindade L.A.F., 1998: Carbon isotopic signatures in n-alkanes of the Potiguar oils, northeastern Brazil. Geochemical, stratigraphic, and data for source rocks in the Potiguar Basin indicate that conditions in depositional environments were variable. Three oil families can be recognized in the basin, e.g., lacustrine, marine-evaporitic, and mixed. How...

Lederer W.J.; Kofuji P.; Schulze D.; Hadley R.; Kieval R.; Kibry M.S.; Niggli E., 1992: Molecular function of the sodium calcium exchanger guinea pig rat and human. Journal of Molecular & Cellular Cardiology 24(SUPPL 4): S13