geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Role of nuclear steroid receptors in apoptosis


, : Role of nuclear steroid receptors in apoptosis. Current Medicinal Chemistry 16(29): 3886-3902

Nuclear steroid receptors (NSR) are ligand-activated transcription factors that play a key role in a variety of vital physiological phenomena including developmental or endocrine signaling, reproduction, and homeostasis. In addition, they are implicated in other important biological processes, such as apoptosis. Modulation of apoptosis by NSR is mostly associated with control of pro-apoptotic versus anti-apoptotic gene expression, and includes both induction and prevention of apoptosis depending on cell type. However, it is unclear how NSR can affect opposing expression of the same gene in different cells. Of note, recently described nongenomic mechanisms of NSR, in particular glucocorticoid receptor translocation to mitochondria, were suggested to be crucial steps for triggering apoptosis. NSR often act solely as nuclear transporters of other regulatory molecules, thus indirectly regulating several apoptosis-related genes. Curiously, NSR are thought to cooperate with the anti-apoptotic endogenous bile acid, ursodeoxycholic acid (UDCA), to prevent programmed cell death. In fact, as cholesterol-derived molecules and due to their chemical and structural similarities to steroid hormones, bile acids also modulate NSR activation. Although the precise link between NSR and UDCA remains unclear, we have demonstrated that the bile acid requires NSR for translocation to the cell nucleus as part of a ligand-receptor complex, using a mechanism similar to that of steroid hormones. Interestingly, other studies revealed that UDCA interacts with the glucocorticoid receptor as a novel and selective NSR modifier. The huge diversity of natural ligands and xenobiotics that bind to NSR and regulate their function represents one of the most exciting drug targets for potential therapeutic intervention. The next decade will almost certainly unveil the remarkable role of NSR in modulating cell fate in human health and disease.

US$29.90

PMID: 19747134


Other references

Reubi, F.; Cottier, P.; Weidmann, P.; Hodler, J., 1977: Kidney function in essential hypertension. Verhandlungen der Deutschen Gesellschaft für Kreislaufforschung 43: 56-60

Kim, D.; Lee, Y.J.; Corry, P.M., 1992: Employment of a turbidimetric assay system to measure heat-induced protein aggregation. 1. We developed a turbidimetric assay system for quantitation of heat-induced protein aggregation which is presumably caused by protein denaturation. 2. Rhodanese in 6M guanidinium chloride was employed in the assay system, because this protein re...

Farzadfar, S.; Zarinkamar, F.; Modarres-Sanavy, S.Ali.Mohammad.; Hojati, M., 2013: Exogenously applied calcium alleviates cadmium toxicity in Matricaria chamomilla L. plants. Cadmium (Cd) toxicity in plants leads to serious disturbances of physiological processes, such as inhibition of chlorophyll synthesis, oxidative injury to the plant cells and water and nutrient uptake. Response of <i>Matricaria chamomilla<...

Quinn B.B.; Grove K., 1994: High-resolution gravity survey of subsurface morphology along the San Andreas Fault north of San Francisco, California. Eos, Transactions, American Geophysical Union 75(44, Suppl

Leps Thomas M., 1988: Rockfill dam design and analysis. Pages 368-387 1988

Navas, J.R.; Bo, N.A., 1996: Brief notes on the birds of the mountainous region of Cordoba and San Luis Breves notas sobre aves de la region serrana de Cordoba y San Luis. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia" e Instituto Nacional de Investigacion de las Ciencias Naturales Extra, 137: 1-4

Stahlschmidt, Z.R.; Lourdais, O.; Lorioux, S.; Butler, M.W.; Davis, J.R.; Salin, K.; Voituron, Y.; DeNardo, D.F., 2014: Morphological and physiological changes during reproduction and their relationships to reproductive performance in a capital breeder. Current reproductive effort typically comes at a cost to future reproductive value by altering somatic function (e.g., growth or self-maintenance). Furthermore, effects of reproduction often depend on both fecundity and stage of reproduction, wher...

Hennis, A.J.M.; Wu, S-Yuh.; Nemesure, B.; Leske, M.Cristina., 2013: Urologic characteristics and sexual behaviors associated with prostate cancer in an african-Caribbean population in barbados, west indies. Prostate cancer (PC) is the principal malignancy affecting African descent men in the Caribbean and the USA. Disparities in incidence, prevalence, and mortality in these populations are poorly understood. We evaluated the urologic characteristics...

Agar, G.; Taspnar, M.S., 2003: Effects of calcium, selenium and zinc on cadmium induced chromosomal aberration in roots of Secale cereale. The influence of different concentrations of Zn2+ Se4+ and Ca2+ on the genotoxicity of cadmium in root cells of rye (Secale cereale) was studied. The results showed that 10-3 M to 10-5 M of Cd2+ ions caused a decrease in mitotic index and an incre...

Potocki-Roth, B., 1978: Viruses as causes of diseases in plants. Kakteen und andere Sukkulenten: 29 (1) 18-19