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Rosiglitazone attenuates endothelial progenitor cell apoptosis induced by TNF-α via ERK/MAPK and NF-κB signal pathways


, : Rosiglitazone attenuates endothelial progenitor cell apoptosis induced by TNF-α via ERK/MAPK and NF-κB signal pathways. Journal of Pharmacological Sciences 117(4): 265-274

The discovery of endothelial progenitor cells (EPCs) provides us with a novel treatment strategy for complications requiring therapeutic revascularization and vascular repair. However, the feasibility of this strategy may be limited due to reduced number and impaired function of EPCs under stimulation of TNF-α. The present study was designed to investigate the effect of rosiglitazone on EPC apoptosis induced by TNF-α and the molecular mechanisms involved. Rosiglitazone attenuated apoptosis of TNF-α-stimulated EPCs in a dose-dependent manner. Rosiglitazone decreased caspase-3 activity and cleavages of caspase-3, caspase-7, and parp. Rosiglitazone also moderated the dissipation of mitochondrial membrane potential caused by TNF-α treatment and reduced the expression of bax and the release of cytochrome c. Furthermore, rosiglitazone inhibited phosphorylations of ERK/MAPK and NF-κB signal molecules. Both ERK and NF-κB inhibitors decreased TNF-α-induced apoptosis of EPCs, as well as the expression of cleaved caspase-3 and parp. These results suggest that rosiglitazone may mediate the inhibitory effect on EPCs apoptosis under TNF-α stimulation through suppression of ERK/MAPK and NF-κB signal pathways.

US$29.90

PMID: 22129539


Other references

Busch Richard M.; West Ronald R., 1986: Heirarchal T-R unit stratigraphy as a framework for Permo-Carboniferous paleoceanographic studies. Abstracts with Programs Geological Society of America: , Pages 282. 1986.

Pursell R.A.; Aguirre C.J., 1991: Fissidens cylindrothecus new species bryopsida fissidentaceae a new species from colombia. Fissidens cylindrothecus, a new species from Colombia, is described by the authors. The authors compare this species unusual characteristics to those of other species in the section Aloma, particularly its peristome and costal structure.

Ling, K.B.; Smith, A.D., 2011: α-Aroyloxyaldehydes: scope and limitations as alternatives to α-haloaldehydes for NHC-catalysed redox transformations. α-Aroyloxyaldehydes are readily prepared bench stable synthetic intermediates. Their ability to act as α-haloaldehyde surrogates for NHC-promoted redox esterifications and in [4+2] cycloadditions is described.

Kefeli, I.E., 1952: Brief review of works on anatomy published in journal "Russkii vrach". Arkhiv Anatomii, Gistologii i Embriologii 29(2): 64-73

Chang, P.K., 1970: Initial isolation and partial characterization of ovulation inhibitor(s) from cerebral tissue of cows. Life Sciences 9(7): 403-413

Meger, M.; Meger Kossien, I.; Schuler Metz, A.; Janket, D.; Scherer, G., 2002: Simultaneous determination of nicotine and eight nicotine metabolites in urine of smokers using liquid chromatography-tandem mass spectrometry. A method based on liquid chromatography tandem mass spectrometry (LC-MSMS) applying atmospheric pressure chemical ionisation (APCI) in the positive ion mode was developed for the direct determination of nicotine, cotinine, trans-3'-hydroxycot...

Forsius, R., 1918: On some Palaearctic Tenthredininae. Some of the results of a revision of the author's work on the sawflies of the old world are given. A new subgenus, six new species and nine new varieties are erected.

Brisbin I.L.Jr, 1969: Bio energetics of nightly weight loss in a captive ring dove. Oriole 34(2): 17-24

Minnes, J.F., 1952: The therapeutic evaluation of cortisone applied topically in ophthalmic diseases. Canadian Medical Association Journal 66(4): 342-347

Fliedner Moritz M.; Klemperer Simon L., 2000: Crustal structure transition from oceanic arc to continental arc, eastern Aleutian Islands and Alaska Peninsula. The Aleutian island arc crosses from the Pacific Ocean to the North-American continent at the island of Unimak. 3-D finite-difference traveltime inversion of our onshore-offshore seismic reflection/refraction data gives a velocity model of the cru...