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Rotigotine: the first new chemical entity for transdermal drug delivery

, : Rotigotine: the first new chemical entity for transdermal drug delivery. European Journal of Pharmaceutics and Biopharmaceutics 88(3): 586-593

Rotigotine is the first, and to date, the only new chemical entity to be formulated for transdermal delivery. Although first approved for the management of Parkinson's disease in Europe in 2007 and Restless Leg Syndrome in 2008, the story of rotigotine began more than twenty years earlier. In this review we outline the historical development of this molecule and its route to licensed medicine status. It has very favourable physicochemical properties for transdermal delivery but it took a significant period to develop from concept to market. The stability problems which led to the temporary withdrawal of the patch are examined and the major clinical studies demonstrating efficacy and safety are outlined. Alternative new therapeutic modalities are also considered.


PMID: 25173087

DOI: 10.1016/j.ejpb.2014.08.007

Other references

Drake, T.M.; Ward, A.E., 2016: Pharmacological management to prevent ileus in major abdominal surgery: a systematic review and meta-analysis. Prolonged ileus is a common complication following gastrointestinal surgery, with an incidence of up to 40 %. Investigations examining pharmacological treatment of ileus have proved largely disappointing; however, recently, several compounds have...

Mussa, G.C.; Pavesio, D., 1963: Behavior of the sedimentation of perchloric-soluble proteins in some diseases of childhood. Minerva Pediatrica 15: 455-461

Harris, R.I., 1978: A method for testing potential bactericides for the prevention of soft rotting of potato tubers. Two techniques developed at Rothamsted were combined to produce a convenient means of assessing potential bactericides for the prevention of [bacterial] soft rot of potato tubers. After receiving crush wounds, as used for gangrene induction, tuber...

Kosykh, V.M., 1972: The taxonomy of the wild apple of the Crimea. In a critical analysis of published work on the subject, the wild Crimean apple is assigned to the species Malus praecox. On the basis of a pollen analysis of the species, its possible apomictic reproduction is postulated.

Harrar, L., 2009: Commentary: Definitions of global health--the 2005 PBS series 'Rx for Survival' 's approach. Journal of Public Health Policy 29(4): 402-403

Tucci, F.; Arienzale, L.; Federico, D. di, 1991: Use of levamisole as an immunomodulator in Italian Friesian cows to prevent low fertility. Over a 2-year period 350 dairy cows (group I) on 100 farms were treated with levamisole at 5 mg/kg at 7 days before the expected date of parturition and again 10-15 days after parturition; there were 350 untreated controls (group II) on the same f...

Dorvee, J.R.; Boskey, A.L.; Estroff, L.A., 2012: Rediscovering Hydrogel-Based Double-Diffusion Systems for Studying Biomineralization. For those seeking to model biomineralization in vitro, hydrogels can serve as excellent models of the extracellular matrix (ECM) microenvironment. A major challenge posed in implementing such systems is the logistics involved, from fundamental eng...

Sauer, L.A.; Martin, A.P.; Stotz, E., 1962: Oxidative phosphorylation in ascites tumor mitochondria. A modified method for the cytochemical fractionation of an ascites tumor is described. The cells are pretreated into 10-3 M EDTA in 0.25 M sucrose before homogenization. Particulate fractions are obtained by the usual centrifugation procedures. Th...

Forstel A., 1983: Re stocking of the eagle owl bubo bubo population in bavaria west germany. From 1965-1980 more than 250 eagle owls B. bubo were released to restock the diminished breeding population. The birds used came from Czechoslovakia, Yugoslavia and from broods reared in captivity. About 12 successful breeding attempts of released...

M.T.rkian; M.E.onomou-Eliopoulos; D.G.E.iopoulos, 1992: Platinum-group minerals and tetraauricupride in ophiolitic rocks of Skyros Island, Greece. Mineralogy and Petrology 47(1): 55-66