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SGK regulation of renal sodium transport


, : SGK regulation of renal sodium transport. Current Opinion in Nephrology and Hypertension 21(5): 534-540

The serum and glucocorticoid regulated kinase (SGK) family of protein kinases shares similar biochemical and hormonal signaling properties; however, the SGK kinases also exhibit distinct differences in regulating renal sodium (Na(+)) transport. This review will highlight recent advances in our understanding of the specificity of SGK kinase signaling and regulation of renal Na(+) transport. Differential expression of SGK kinases at the cellular and subcellular levels contributes to signaling specificity. New evidence indicates that SGK1 associates with the apical cell membrane of cortical collecting duct cells to regulate open probability of the epithelial Na(+) channel (ENaC). Scaffold proteins can also recruit SGK1 to multiprotein complexes for regulation of ENaC expression in the apical membrane. Recent SGK1 knockout models have implicated the NaCl co-transporter (NCC) as another target of SGK1 regulation. Less is known about the function of SGK2 or SGK3, but both kinases can regulate Na(+)/H(+) exchanger 3 (NHE3) activity. The SGK kinases assume distinct roles in regulating Na transport in both proximal and distal elements of the kidney tubule. Future examination of the molecular mechanisms by which the SGK kinases regulate specific substrates will inform our understanding of how these kinases contribute to the physiology of renal Na(+) transport.

US$19.90

PMID: 22691875

DOI: 10.1097/MNH.0b013e32835571be


Other references

Stuyk, D.; Vanorle, L., 1981: Economic aspects of forage crops production. 3. Application of management principles to choice of forage crops. Rational choice of forage crops is best made using partial budgeting techniques, but this can pose problems because in most cases forage crops do not have a financial value of their own. The greater value of one crop over another can be evaluated...

Simon E.J.; Bonnet K.A.; Hiller J.M.; Rieman M.W.; Merrifield R.B., 1979: Opioid activity of synthetic and naturally occurring enkephalin peptides. Analogs of methionine[Met]-enkephalin were synthesized, with changes at the N- or C-terminus. Changes at only the N-terminus increased in vitro stability of peptides when they were incubated in homogenates. Injection of peptides intracerebrally in...

Vaissaire, J.; Baroux, D.; Salingardes, F.; Thong, P.R., 1995: Identification of Erysipelothrix rhusiopathiae in asymptomatic carrier pigs, turkeys and ducks. Material was received from apparently healthy animals from 28 farms. A total of 150 samples, each one containing material from the hearts, intestines or tonsils of 2-4 animals from the same farm, were tested: 55 from pigs, 37 from turkeys, 37 from...

Cherry, M., 1977: Lucerne under attack. Big farm management: 54

Parker, A.L.; Likar, L.L.; Dawicki, D.D.; Rounds, S., 1996: Mechanism of ATP-induced leukocyte adherence to cultured pulmonary artery endothelial cells. Previously we have shown that ATP enhances the adherence of HL-60 cells and human neutrophils to bovine pulmonary artery endothelial cells. The current investigations extend earlier findings by showing that ATP and UTP dose-dependently stimulate h...

Booth, A.D.; Sobbold, R.S.; Wacker, G.; Leppard, G.G.; Naylor, J.M.; Steeves, T.A., 1964: Laser In Cytology. Nature 203: 789-789

Figueiredo, A.; Moreira, P.; Parada, B.; Nunes, P.; Macário, F.; Bastos, C.; Mota, A., 2007: Risk factors for delayed renal graft function and their impact on renal transplantation outcome. Objective. The objective of this study was to evaluate the risk factors for delayed graft function (DGF) and their influence on renal graft outcome.Patients and Methods. We reviewed 1462 consecutive renal transplantation and identified 245 patient...

Mostyn, A.; Pearce, S.; Stephenson, T.; Symonds, M.E., 2004: Hormonal and nutritional regulation of adipose tissue mitochondrial development and function in the newborn. Growth, development, and maturation of adipose tissue in the fetus can determine both survival at birth as well as having longer term consequences for adult disease. The mitochondrial proteins uncoupling protein (UCP) 1, voltage dependent anion ch...

D.L.lla, F.; Bechelli, G.; Cavallini, S., L., 1966: On the applicability of the cutaneous test for passive anaphylaxis to the study of toxoplasmosis. Hyperimmune sera have been produced in rats, rabbits, guinea-pigs and mice. Also a human serum has been studied with dye test titer 1:2000. The 2nd injection was performed with the following antigens: peritoneal exsudate from mouse and hamster, ei...

Siassipour, A.; Katz, J., 2017: Oral mucous membrane pemphigoid associated with hypothyroidism: A retrospective study and a case report. The purpose of the study was to evaluate the relationship between mucous membrane pemphigoid and a state of hypothyroidism. The study included analysis of the dental charts of 40 subjects with clinically and histologically confirmed diagnosis of m...