+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

SSR149415, a non-peptide vasopressin V1b receptor antagonist, has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model

, : SSR149415, a non-peptide vasopressin V1b receptor antagonist, has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model. Naunyn-Schmiedeberg's Archives of Pharmacology 379(1): 101-106

Olfactory bulbectomy (OBX) in rats causes several behavioral and neurochemical CNS changes, reminiscent of symptoms of human depression. Such depression-like behavior after OBX can be reversed with antidepressants. Recently, a connection between the vasopressin 1b (V1b) receptor and the development of depression has been suggested; therefore, a vasopressin V1b receptor antagonist (SSR149415) was investigated in the OBX model. Male rats received olfactory bulbectomy or sham surgery. After recovery, animals received 14 consecutive daily doses of SSR149415 (10 or 30 mg/kg), imipramine (20 mg/kg), or vehicle (5% hydroxy-propyl methylcellulose). Animals were tested in an open field after acute treatment, on days 7 and 14 of treatment and 1 week after cessation of treatment. Similar to imipramine, repeated, but not acute, administration of SSR149415 completely reversed OBX-induced hyperactivity, leaving activity in shams unaffected. This reversal of OBX-induced hyperactivity in the SSR149415 treated rats was still present 7 days after cessation of treatment. Although the behavioral effects of treatment with SSR149415 were specific for the OBX animals, adrenal gland weights were reduced in both sham and OBX animals treated with 30 mg/kg SSR149415. Chronic but not acute administration of SSR149415 normalizes OBX-induced hyperactivity up to 1 week after cessation of treatment, suggesting that a V1b receptor antagonist may have long-lasting antidepressant activity.


PMID: 18668225

DOI: 10.1007/s00210-008-0336-1

Other references

Safarzadeh, S.; Ronaghi, A.; Karimian, N., 2013: Effect of cadmium toxicity on micronutrient concentration, uptake and partitioning in seven rice cultivars. Heavy metal uptake, translocation and partitioning differ greatly among plant cultivars and plant parts. A pot experiment was conducted to determine the effect of cadmium (Cd) levels (, 45 and 9 mg kg?1 soil) on dry matter yield, and concentration...

Boglione, L.; Ruggiero, T.; De Nicolò, A.; D'Avolio, A.; Di Perri, G., 2017: A Possible Role of Therapeutic Drug Monitoring in Virological Breakthrough during Simeprevir and PEG-IFN Treatment in HCV-4. Intervirology 59(5-6): 283-284

Sotnikov, V.N., 1997: The great reed warbler Acrocephalus arundinaceus in Kirov region.. Russkii Ornitologicheskii Zhurnal Ekspress Vypusk 7: 10-11

Salvini, L.; Scardigli, G.; Guidi, G., 1959: Humoral changes after fatty meal in presenile florid diabetes. Giornale di Gerontologia 7: 1006-1012

Bates, D.G., 2007: Special issue on marine resources. This journal issue examines human ecology in coastal and fishing communities; how, whether and to what extent people will develop sustainable systems of common resource exploitation; and the sociopolitical and cultural dimensions of efforts to use...

Glover, D., 2005: Let's tackle errors and omissions head-on. Journal of Wound Care 14(3): 95-95

Kas'ian, T.M., 1987: New methods of diagnosing strabismus and amblyopia in young children. Oftalmologicheskii Zhurnal: 7-10

Farashchuk, N.F.; Rakhmanin, Y.A.; Savostikova, O.N.; Telenkova, O.G., 2015: Crystallographic evaluation of structural changes in water. The study of the structural state of tap water that has been stored for two days in the packaging materials of various type and in different conditions, was performed with the use of crystallographic method for the investigation of liquids based o...

Schöfl, R., 1994: Pancreatic carcinoma--diagnosis and screening--endoscopic therapy. Diagnosis of pancreatic carcinoma is nowadays established by means of transabdominal sonography and computed tomography. In cases remaining unclear or accompanied by obstructive jaundice ERCP is also required. Small tumours can only be detected by...

Shang, Y.; Wang, M.; Xiao, G.; Wang, X.; Hou, D.; Pan, K.; Liu, S.; Li, J.; Wang, J.; Arif, B.M.; Vlak, J.M.; Chen, X.; Wang, H.; Deng, F.; Hu, Z., 2017: Construction and Rescue of a Functional Synthetic Baculovirus. Synthetic viruses provide a powerful platform to delve deeper into the nature and function of viruses as well as to engineer viruses with novel properties. So far, most synthetic viruses have been RNA viruses (<30 kb) and small DNA viruses, suc...