geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating μ-opioid receptors


, : Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating μ-opioid receptors. Journal of Pharmacology and Experimental Therapeutics 341(1): 43-50

Previous studies in vivo have shown that salsolinol, the condensation product of acetaldehyde and dopamine, has properties that may contribute to alcohol abuse. Although opioid receptors, especially the μ-opioid receptors (MORs), may be involved, the cellular mechanisms mediating the effects of salsolinol have not been fully explored. In the current study, we used whole-cell patch-clamp recordings to examine the effects of salsolinol on dopamine neurons of the ventral tegmental area (VTA) in acute brain slices from Sprague-Dawley rats. Salsolinol (0.01-1 μM) dose-dependently and reversibly increased the ongoing firing of dopamine neurons; this effect was blocked by naltrexone, an antagonist of MORs, and gabazine, an antagonist of GABA(A) receptors. We further showed that salsolinol reduced the frequency without altering the amplitude of spontaneous GABA(A) receptor-mediated inhibitory postsynaptic currents in dopamine neurons. The salsolinol-induced reduction was blocked by both naltrexone and [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin, an agonist of MORs. Thus, salsolinol excites VTA-dopamine neurons indirectly by activating MORs, which inhibit GABA neurons in the VTA. This form of disinhibition seems to be a novel mechanism underlying the effects of salsolinol.

US$19.90

PMID: 22209890

DOI: 10.1124/jpet.111.186833


Other references

Iarŭkov, A.; Savova, I.; Slŭncheva, B.; Veltova, L., 1988: Oxytocin infusion and nonhemolytic neonatal hyperbilirubinemia. Akusherstvo i Ginekologiia 27(1): 41-44

Arana, J.; Tovar, J.A.; Garay, J., 1986: Abnormal preoperative and postoperative esophageal peristalsis in gastroesophageal reflux. Extended 24-hour pH monitoring and esophageal manometry before and 6 months after Nissen fundoplication in a group of 14 children with symptomatic gastroesophageal reflux (GER), of whom 12 had esophagitis, have shown that all patients were clinica...

Hope, I.D.; Huikeshoven, F.J.; Gilbert, R.D.; Power, G.G.; Longo, L.D., 1989: Errors in microsphere determination of cardiac output: a computer simulation in fetal sheep. Through use of a compartmental model, we simulated the measurement of cardiac output and distribution by means of radioactively labeled microspheres in fetal lambs with weights between 0.5 and 3 kg. A systematic error in measured cardiac output ca...

Matoba, A.; Matsuyama, N.; Shibata, S.; Masaki, E.; Emala, C.W.; Mizuta, K., 2017: The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways. Obesity is a risk factor for asthma and influences airway hyperresponsiveness, which is in part modulated by airway smooth muscle proliferative remodeling. Plasma free fatty acids (FFAs) levels are elevated in obese individuals, and long-chain FFA...

Noel, R.; Paillot, A., 1927: Participation of the nucleus of the cells of the silk glands of the silkworm in the formation of the silk-producing fluid. The silk glands were sectioned and stained at various stages after the 5th moult. The nucleoli divided and spread into the chromatin material of the cells. In some cells the finely divided nuclei appeared in the form of small blocks; in others the...

Vandendorpe, L.; Cuvelier, L.; Maison, B., 2008: Human visual weighted quantization for transform/subband image coding revisited for interlaced pictures. This correspondence addresses the problem of human visual weighted quantization for transform/subband coding of interlaced pictures. Merged field coding is assumed. The criterion proposed for the optimization of the quantizer is the distortion mea...

Mullerova, J., 2004: Use of digital aerial photography for sub-alpine vegetation mapping: a case study from the Krkonose Mts., Czech Republic. Multispectral aerial photographs from 1986, 1989 and 1997 were used for mapping and assessment of changes in sub-alpine vegetation of the Krkonose Mts Plateau (1300 to 1400 m a. s. l.), Czech Republic. Scanned aerial photographs were digitally pro...

Brown, J.; Farquhar, C., 2016: Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome. Label="BACKGROUND">Subfertility due to anovulation is a common problem in women. First-line oral treatment is with antioestrogens such as clomiphene citrate, but resistance may be apparent with clomiphene. Alternative and adjunctive t...

Duprez, A.; Simons, M., 1963: Concerning some abdominal tragedies in the course of cortisone treatments. Patients receiving more than 15 mg deltacorti-some /day may have severe gastric hemorrhage, gastric or intestinal performation, or colonic necrosis. Six of the 14 died, including all r cases with colonic necrosis. Dosage/day is more important than...

Maillet, Julie O'sullivan, Reviewer, 1996: Nutrition for the hospitalized patient (book review). Journal of the American Dietetic Association 96: 8