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SensSB: a software toolbox for the development and sensitivity analysis of systems biology models

, : SensSB: a software toolbox for the development and sensitivity analysis of systems biology models. Bioinformatics 26(13): 1675-1676

SensSB (Sensitivity Analysis for Systems Biology) is an easy to use, MATLAB-based software toolbox, which integrates several local and global sensitivity methods that can be applied to a wide variety of biological models. In addition to addressing the sensitivity analysis problem, SensSB aims to cover all the steps involved during the modeling process. The main features of SensSB are: (i) derivative and variance-based global sensitivity analysis, (ii) pseudo-global identifiability analysis, (iii) optimal experimental design (OED) based on global sensitivities, (iv) robust parameter estimation, (v) local sensitivity and identifiability analysis, (vi) confidence intervals of the estimated parameters and (vii) OED based on the Fisher Information Matrix (FIM). SensSB is also able to import models in the Systems Biology Mark-up Language (SBML) format. Several examples from simple analytical functions to more complex biological pathways have been implemented and can be downloaded together with the toolbox. The importance of using sensitivity analysis techniques for identifying unessential parameters and designing new experiments is quantified by increased identifiability metrics of the models and decreased confidence intervals of the estimated parameters. SensSB is a software toolbox freely downloadable from approximately gingproc/SensSB.html. The web site also contains several examples and an extensive documentation. Supplementary data are available at Bioinformatics online.


PMID: 20444837

DOI: 10.1093/bioinformatics/btq242

Other references

Balasheva, I.I.; Kalinina, L.V., 1970: Epidemiology of leukosis in children in Tomsk and the Tomsk region. Problemy Gematologii i Perelivaniia Krovi 15(8): 50-53

Bakirova, R.E.; Tazhbaeva, E.M.; Muravleva, L.E.; Fazylov, S.D.; Akhmetova, S.B., 2016: The study of quality characteristics of the hydrogel ointments and films based on copolymers divinyl esters of diethylene glycol. The possibility of using a hydrogel based on divinyl ether co- and terpolymer of diethylene glycol as the backbone polymer for incorporating water-soluble medicinal substances was examined. The character of the influence of emulsifiers, plasticize...

Shawhan, R.R.; Porta, C.Rees.; Bingham, J.R.; McVay, D.P.; Nelson, D.W.; Causey, M.Wayne.; Maykel, J.A.; Steele, S.R., 2015: Biliary leak rates after cholecystectomy and intraoperative cholangiogram in surgical residency. Postoperative bile leak (BL) after cholecystectomy is a rare but dreaded complication, and is felt to be increased during surgical training. We sought to determine the incidence of BL after selective intraoperative cholangiogram (IOC) at a teachin...

Görner, H., 2007: Oxygen uptake upon photolysis of 1,4-benzoquinones and 1,4-naphthoquinones in air-saturated aqueous solution in the presence of formate, amines, ascorbic acid, and alcohols. The effects of oxygen in the photoreduction of 1,4-benzoquinone (BQ), 1,4-naphthoquinone (NQ), and a series of derivatives were studied in aqueous solution in the presence of acetonitrile and formate, aliphatic amines, e.g., EDTA or triethylamine,...

Palmer, J.M.; Weisbrodt, N.W.; Castro, G.A., 1984: Trichinella spiralis: intestinal myoelectric activity during enteric infection in the rat. The objective was to characterize changes in the host's small intestinal smooth muscle contractile activity caused by the enteric stages of the nematode, Trichinella spiralis, during primary infection. Myoelectric activity was recorded from e...

Kudrin, A.N.; Smolenskii, V.S.; Khusannov, V.M.; Abinder, A.A., 1988: Treatment of unstable stenocardia with alpha-tocopherol. Sovetskaia Meditsina: 78-80

Borck, K.; Beggs, J.D.; Brammar, W.J.; Hopkins, A.S.; Murray, N.E., 1976: Construction in vitro of transducing derivatives of phage lambda. Methods are described for the construction of plaque-forming, transducing derivatives of phage .lambda., using appropriate receptor genomes and fragments of DNA generated by the restriction enzymes endo R.EcoRI and endo R.HindIII. The general prop...

Honnma, H.; Baba, T.; Sasaki, M.; Hashiba, Y.; Oguri, H.; Fukunaga, T.; Endo, T.; Asada, Y., 2014: Serum anti-Mullerian hormone levels affect the rate of ongoing pregnancy after in vitro fertilization. We used logistic regression analysis to investigate the relationship between serum anti-Mullerian hormone (AMH) levels and the rate of ongoing pregnancy. Retrospective data were collected from 1043 women who had undergone their first cycle of in v...

Rosén, A.; Emmelin, M.; Carlsson, A.; Hammarroth, S.; Karlsson, E.; Ivarsson, A., 2012: Mass screening for celiac disease from the perspective of newly diagnosed adolescents and their parents: a mixed-method study. Mass screening for celiac disease (CD) as a public health intervention is controversial. Prior to implementation, acceptability to the targeted population should be addressed. We aimed at exploring adolescents' and parents' experiences o...

Amelina O.P., 1971: Some aspects of surgical policy in treatment of fistulas of the descending colon. Vestnik Khirurgii Imenii I I Grekova 106(3): 45-47