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Seretide: a pharmacoeconomic analysis


, : Seretide: a pharmacoeconomic analysis. Journal of Medical Economics 11(3): 555-570

The costs of asthma and chronic obstructive pulmonary disease (COPD), the two most common chronic respiratory illnesses, are substantial and rising. The fixed-dose combination of fluticasone and salmeterol has been a safe and effective therapy for these diseases. To review the pharmacoeconomic impact of the fixed-dose combination of inhaled fluticasone and salmeterol in asthma and COPD. A systematic review of the literature was carried out to identify pharmacoeconomic studies with fixed-dose salmeterol and fluticasone (Seretide, Advair, Viani). In addition, abstracts from recent respiratory meetings were sought, and any unpublished data were requested from the manufacturer. For asthma, when compared to treatment with inhaled corticosteroid monotherapy and antileukotrienes, alone or combined, salmeterol/fluticasone inhalation produced a higher proportion of successfully treated weeks, improvement in lung function and quality of life, and fewer treatment failures. The costs per quality-adjusted life year (QALY) for fluticasone/salmeterol have been favourable not only in patients with moderate to severe disease but also in patients with mild disease or patients not previously treated with a maintenance therapy. The excess cost per QALY varied from US$2,670 to US$26,445. For COPD, a clear reduction in exacerbation rates and improvement in quality of life has been demonstrated with salmeterol/fluticasone along with a likely improvement in survival rates. The incremental cost per QALY ratio for fluticasone/salmeterol against placebo ranged from US$9,512 to US$64,038. The data currently available suggest that the cost effectiveness of combination therapy with fluticasone and salmeterol is favourable for asthma and COPD in a variety of clinical settings.

US$19.90

PMID: 19450105

DOI: 10.3111/13696990802320908


Other references

Hootman, J.M., 2004: Acromioclavicular Dislocation: Conservative or Surgical Therapy. REFERENCE: Phillips AM, Smart C, Groom AFG. Acromioclavicular dislocation: conservative or surgical therapy. Clin Orthop. 1998;353:10-17. CLINICAL QUESTION: Among patients with acromioclavicular (AC) dislocation, does surgical intervention produce...

Hazell, P.; Mirzaie, M., 2013: Tricyclic drugs for depression in children and adolescents. There is a need to identify effective and safe treatments for depression in children and adolescents. While tricyclic drugs are effective in treating depression in adults, individual studies involving children and adolescents have been equivocal....

Vanaja, T.; Radhakrishnan, V.V., 1998: Identification of an alternate cytoplasmic male sterile source in rice. International Rice Research Notes 28(3): 8-9

Garber R.W.; Forrest J.; Newman L., 1981: Conversion rates in power plant plumes based on filter pack data the oil fired northport long island new york usa plume. Atmospheric Environment 15(10-11): 2283-2292

Martinez, B.D.; Wiegand, C.S.; Evans, P.; Gerhardinger, A.; Mendez, J., 2006: Computer-assisted instrumentation during endoscopic transaxillary first rib resection for thoracic outlet syndrome: a safe alternate approach. The purpose of this article is to discuss the feasibility of using computer-enhanced instrumentation to improve visualization and therefore patient safety during transaxillary first rib resection. From November 1998 to July 2005, 105 patients who...

Race, M.S.; Race, M.S., 1994: Anticipating the reaction: public concern about sample return missions. Shifts in public attitude that may affect extraterrestrial sample return include increased public participation in the legal and regulatory environment, institutionalized public vigilance, politicization of technological debates and shifts in the...

Khan, A.O., 2014: CABP4 mutations do not cause congenital stationary night blindness. Ophthalmology 121(3): E15-E15

Finn, H.; Bienia, M., 1979: Hepatologic dispensaire for blood donors. By means of hepatological examinations of 119 blood donors who became conspicuous by liver screenings in 57 cases we could prove an adipose degeneration without, in 16 cases a fatty degeneration of the liver without, in 9 cases an adipose degenera...

Sironi, C.; Baccin, G.; Pontiggia, D.; Santo, S., 2007: An alternative to discussion of the graduation dissertation in the Nursing Degree Course. The need to modify the nursing curriculum as decreed in April 2001 beginning from the academic year 2003/2004 together with the belief that the dissertation is not the best way for nurses to demonstrate what they have learnt at the end of the bach...

Kendler, K.S.; Gruenberg, A.M.; Strauss, J.S., 1981: An independent analysis of the copenhagen denmark sample of the danish adoption study of schizophrenia 2. the relationship between schizotypal personality disorder and schizophrenia. To assess the relationship between human schizophrenia and schizotypal personality disorder (SPD) as defined in DSM-III (Diagnostic and Statistical Manual of mental Disorders-III), the interviews of relatives from the Danish Adoption Study of Schi...