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Sevoflurane postconditioning provides neuroprotection against brain hypoxia-ischemia in neonatal rats

, : Sevoflurane postconditioning provides neuroprotection against brain hypoxia-ischemia in neonatal rats. Neurological Sciences 35(9): 1401-1404

Application of volatile anesthetics after brain ischemia provides neuroprotection in adult animals (anesthetic postconditioning). We tested whether postconditioning with sevoflurane, the most commonly used general anesthetic in pediatric anesthesia, reduced neonatal brain injury in rats. Seven-day-old Sprague-Dawley rats were subjected to brain hypoxia-ischemia (HI). They were postconditioned with sevoflurane in the presence or absence of 5-hydroxydecanoic acid, a mitochondrial KATP channel inhibitor. Sevoflurane postconditioning dose-dependently reduced brain tissue loss observed 7 days after brain HI. This effect was induced by clinically relevant concentrations and abolished by 5-hydroxydecanoic acid. These results suggest that sevoflurane postconditioning protects neonatal brain against brain HI via mitochondrial KATP channels.


PMID: 24705859

DOI: 10.1007/s10072-014-1726-4

Other references

Zhu, C.G., 1981: A study on the various parameters for measurement of cardiac output by impedance method. Zhonghua Xin Xue Guan Bing Za Zhi 9(3): 232-234

Paludan, N.; Begtrup, J., 1982: Dieffenbachia maculata (Lodd.) G. Don. Virus attack in Danish cultures, survey and diagnosis. Dasheen mosaic virus (DMV) was one of 2 viruses found in a survey of the imported ornamental plant Dieffenbachia maculata in 11 nurseries in Denmark; it was found in 2 plants showing chlorotic vein bands and retarded growth, among 4500 plants exam...

Gibbins, E.G., 1939: Simuliidae. 9 spp. of Simulium were collected on Ruwenzori, 6 of which were bred and their immature forms descr. and figured.

Perry E.C.J.; Gilkeson R.H.; Grundl T.J., 1980: Stable isotope relations in water of the Cambrian-Ordovician aquifer of northern Illinois. Eos, Transactions, American Geophysical Union 61(17): 230

Lee, S.A.; Khalique, Z.; Gale, C.A.; Wong, B., 2005: Intracellular trafficking of fluorescently tagged proteins associated with pathogenesis in Candida albicans. Proteins that enter the secretory pathway play important roles in virulence and pathogenesis in Candida albicans, but our understanding of the trafficking of these proteins is in its early stages. In Saccharomyces cerevisiae, dominant negative all...

Salari, J.W.O.; Leermakers, F.A.M.; Klumperman, B., 2011: Pickering emulsions: wetting and colloidal stability of hairy particles--a self-consistent field theory. The assembly of sterically stabilized colloids at liquid-liquid interfaces is studied with the self-consistent field (SCF) theory using the discretization scheme that was developed by Scheutjens, Fleer, and co-workers. The model is based on a poly...

Peirano V.P.; Borie B.G.; Aguilera S.M., 1987: Biochemistry of soils derived from volcanic ashes. V. Polyphenol oxidases activity determination. Polyphenoloxidase activity was determined in seven volcanic soils with high contents of stabilized organic matter and in two alluvial soils of low organic matter content. Polyphenoloxidase activity was greater in volcanic than in alluvial soils, a...

Woodlard G.R.; Rathbone E.B.; Novellie L., 1977: Structural studies on 3 hemi cellulose b fractions from the husk of sorghum grain. Carbohydrate Research 59(2): 547-552

Shaver, K., 2004: New report on nursing education programs will allow progress to be tracked. Tar Heel Nurse 66(5): 21-21

Lynch, M., 2002: Intron evolution as a population-genetic process. Debate over the mechanisms responsible for the phylogenetic and genomic distribution of introns has proceeded largely without consideration of the population-genetic forces influencing the establishment and retention of novel genetic elements. How...